脑脉泰胶囊降低急性脑梗死病人血脂及超敏C反应蛋白水平的疗效观察

目的:探讨脑脉泰胶囊对急性脑梗死患者血脂、超敏C反应蛋白(hs-CRP)的疗效。方法:60例急性脑梗死患者随机分为治疗组与对照组各30例,治疗组在常规治疗基础上加服脑脉泰胶囊2粒,每日3次,于治疗1月后测定两组血清胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、hs-C反应蛋白浓度,并与对照组比较。结果:治疗组经脑脉泰胶囊治疗1月后血清胆固醇、甘油三酶、低密度脂蛋白胆固醇、hs-C反应蛋白浓度分别低于治疗前水平(P<0.05),并升高高密度脂蛋白胆固醇(P<0.05),血清hs-CRP测定值低于治疗前水平(P<0.05),有统计学意义。结论:脑脉泰胶囊能够从多种途径有效改善脑微循环、抗动脉硬化、降低血脂、稳定斑块及抗炎作用,可有效防治脑血管疾病。     

泰式按摩治疗腰肌劳损的初步探讨

近年来,随着生活节奏和工作方式的改变,腰肌劳损的患者明显增多,已成为中国和泰国临床最常见的疾病之一。按摩手法是缓解和治疗腰肌劳损的有效手段之一。因此总结了泰式按摩治疗腰肌劳损的规律和特色,以期为今后泰式按摩在中国进一步发展奠定基础,也为其更好地走向世界创造条件。     

Mitochondrial DNA polymorphisms in Thailand

Nucleotide sequences of the D-loop region of human mitochondrial DNA from six small ethnic groups of Thailand i.e., Hill tribes (Lisu and Mussur), Phuthai, Lao Song, Chong, and aboriginal Sakai, were analyzed. The sequences were compared with those of native Thai populations from two provinces, Chiang Mai and Khon Kaen. Based on a comparison of the 563-bp sequences in 215 Thai individuals, 137 different sequence types were observed. Of these, 124 were unique to their respective populations, whereas 13 were shared between two to five populations. The intergenic COII/tRNA^Lys 9-bp deletion was observed in every Thai population examined, except for the Sakai, with varying frequencies ranging from 18% to 40%. The D-loop sequences variation, and phylogenetic analysis, suggested that the 9-bp deletion had occurred in a very ancient ancestry of Southeast Asians, although multiple origins of the deletion cannot be ruled out. Genetic distances, based on net nucleotide diversities, between populations revealed that the Sakai were distantly related to the other Thai populations, while the Lao Song and Chong were closely related to each other. Close genetic affinities were also observed among the Hill tribes, Phuthai, and native northeast Thai (Khon Kaen), indicating that they may share some degree of the common ancestral maternal lineages. Received: October 23, 2000 / Accepted: December 4, 2000     

The validity and reliability of the Thai version of the Kujala score for patients with patellofemoral pain syndrome

Purpose: To develop a Thai version of the Kujala score and show the evaluation of the validity and reliability of the score.

Method: The Thai version of the Kujala score was developed using the forward–backward translation protocol. The 49 PFPS patients answered the Thai version of questionnaires including the Kujala score, Short Form-36 (SF-36) and International Knee Documentation Committee (IKDC) Subjective Knee Form. The validity between the scores has been tested. The reliability was assessed using test–retest reliability and internal consistency.

Results: The Thai version of the Kujala score showed a good correlation with Thai IKDC Subjective Knee Form (Pearson’s correlation coefficient; r?=?0.74: p?Thai SF-36 subscales of physical component summary, total score and role physical (r?=?0.586, 0.571 and 0.524, respectively: p?p?p?Conclusion: The Thai version of the Kujala score has shown good validity and reliability. This score can be effectively used for evaluating Thai patients with patellofemoral pain syndrome.

• Implications for Rehabilitation

• The Kujala score is a self-administered questionnaire for patients with patellofemoral pain syndrome (PFPS).

• The validity and reliability of the Thai version of Kujala are compatible with other versions (Turkish, Chinese and Persian version).

• The Thai version of Kujala has been shown to have validity and reliability in Thai PFPS patients and can be used for clinical evaluation and also in the research work.

     

The drug situation in Thailand: the role of government and the police

Thailand has long dealt with the drug problem and has used several strategies to control it, including promulgating and amending drug laws, implementing drug suppression and prevention policies, cooperating with international organizations and, more recently, developing treatment facilities. Although Thailand has recently received positive results regarding reducing the opium cultivation area in the Golden Triangle and in arresting some major drug-trafficking individuals, three important issues still remain: (1) the continuation of using Thailand's advanced transportation system for the movement of illicit drug activities, (2) the rapid increase of amphetamine use among teenagers and (3) the Thai police officers' lack of concern about the drug problem and insufficient knowledge about drug laws. The article concludes that the Thai government must emphasize drug prevention strategies and the interception of illicit transported drugs and motivate its police officers to more fully enforce drug laws. In addition, more research is needed to measure the effectiveness of the drug prevention strategies and treatment programs.     

Red strain oryza sativa-unpolished thai rice prevents oxidative stress and colorectal aberrant crypt foci formation in rats

Oxidative stress has been proposed to be involved in colorectal cancer development. Many dark pigments of plants have potent oxidative stress preventive properties. In this study, unpolished Thai rice was assessed for antioxidant activity using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-azinobis-3-ethylbenzothiazoline-6-sulfonic acid (ABTS) methods. Red strain unpolished Thai rice was also administered to rats exposed to azoxymethane (AOM) for induction of aberrant crypt foci (ACF). Serum malondialdehyde (MDA) and ferric reducing antioxidant power (FRAP) were investigated for cellular oxidative stress and serum antioxidants, respectively. Red pigment unpolished Thai rice demonstrated high antioxidant activity and was found to significantly and dose dependently decrease the total density and crypt multiplicity of ACF. Consumption of Thai rice further resulted in high serum antioxidant activity and low MDA cellular oxidative stress. Interestingly, the density of ACF was strongly related to MDA at r=0.964, while it was inversely related with FRAP antioxidants (r=-0.915, p<0.001). The results of this study suggest that the consumption of red strain of unpolished Thai rice may exert potentially beneficial effects on colorectal cancer through decrease in the level of oxidative stress.