全文获取类型
收费全文 | 37970篇 |
免费 | 3430篇 |
国内免费 | 465篇 |
专业分类
耳鼻咽喉 | 336篇 |
儿科学 | 2074篇 |
妇产科学 | 393篇 |
基础医学 | 4294篇 |
口腔科学 | 544篇 |
临床医学 | 3331篇 |
内科学 | 2678篇 |
皮肤病学 | 216篇 |
神经病学 | 15073篇 |
特种医学 | 364篇 |
外科学 | 1242篇 |
综合类 | 3160篇 |
现状与发展 | 3篇 |
一般理论 | 1篇 |
预防医学 | 3110篇 |
眼科学 | 136篇 |
药学 | 3147篇 |
8篇 | |
中国医学 | 1468篇 |
肿瘤学 | 287篇 |
出版年
2024年 | 186篇 |
2023年 | 927篇 |
2022年 | 1407篇 |
2021年 | 2042篇 |
2020年 | 1894篇 |
2019年 | 1766篇 |
2018年 | 1615篇 |
2017年 | 1730篇 |
2016年 | 1773篇 |
2015年 | 1543篇 |
2014年 | 2552篇 |
2013年 | 3487篇 |
2012年 | 1977篇 |
2011年 | 2402篇 |
2010年 | 1847篇 |
2009年 | 1817篇 |
2008年 | 1885篇 |
2007年 | 1716篇 |
2006年 | 1388篇 |
2005年 | 1185篇 |
2004年 | 961篇 |
2003年 | 868篇 |
2002年 | 766篇 |
2001年 | 548篇 |
2000年 | 442篇 |
1999年 | 364篇 |
1998年 | 420篇 |
1997年 | 337篇 |
1996年 | 260篇 |
1995年 | 219篇 |
1994年 | 180篇 |
1993年 | 166篇 |
1992年 | 166篇 |
1991年 | 162篇 |
1990年 | 133篇 |
1989年 | 127篇 |
1988年 | 116篇 |
1987年 | 89篇 |
1986年 | 44篇 |
1985年 | 80篇 |
1984年 | 52篇 |
1983年 | 35篇 |
1982年 | 60篇 |
1981年 | 27篇 |
1980年 | 27篇 |
1979年 | 19篇 |
1978年 | 16篇 |
1977年 | 15篇 |
1976年 | 10篇 |
1973年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
101.
Background A number of studies have shown that the diagnosis of developmental language disorder (DLD) can be unstable over time, such that young children with a diagnosis of DLD may show symptoms more characteristics of autism spectrum disorder (ASD) at a later date.
Method To estimate the types and prevalence of ASD 469 individuals with a DLD, consecutively assessed in the same clinic during a period of 10 years, and 2345 controls from the general population were screened for ASD through the nationwide Danish Psychiatric Central Register (DPCR). The mean length of observation was 34.7 years, and the mean age at follow-up 35.8 (range: 28.3–46.7) years.
Results At follow-up, 10 (2.1%) in the DLD group and two (0.09%) in the comparison group were known in the DPCR with a diagnosis of any ASD ( P < 0.0001; odds ratio = 25.5; 95% confidence interval 5.5–116.9).
Conclusion Our results provide additional support to the notion that DLD is a marker of increased vulnerability to the development of ASD. 相似文献
Method To estimate the types and prevalence of ASD 469 individuals with a DLD, consecutively assessed in the same clinic during a period of 10 years, and 2345 controls from the general population were screened for ASD through the nationwide Danish Psychiatric Central Register (DPCR). The mean length of observation was 34.7 years, and the mean age at follow-up 35.8 (range: 28.3–46.7) years.
Results At follow-up, 10 (2.1%) in the DLD group and two (0.09%) in the comparison group were known in the DPCR with a diagnosis of any ASD ( P < 0.0001; odds ratio = 25.5; 95% confidence interval 5.5–116.9).
Conclusion Our results provide additional support to the notion that DLD is a marker of increased vulnerability to the development of ASD. 相似文献
102.
Matt G Kushner Suck Won Kim Christopher Donahue Paul Thuras David Adson Michael Kotlyar James McCabe Jillian Peterson Edna B Foa 《Neuropsychopharmacology》2007,62(8):835-838
BACKGROUND: D-cycloserine (DCS), a glutamatergic partial N-methyl-d-aspartate (NMDA) agonist, can facilitate extinction learning related to cued fear in animals and humans. We predicted that DCS would accelerate obsession-related distress reduction in patients with obsessive-compulsive disorder (OCD) undergoing extinction-based exposure therapy. METHODS: We administered DCS (125 mg) or placebo in a double-blind fashion to individuals with OCD approximately 2 hours before each exposure session. RESULTS: D-cycloserine decreased both the number of exposure sessions required to achieve clinical milestones and the rate of therapy dropout. After four exposure sessions, patients in the DCS group reported significantly greater decreases in obsession-related distress compared with the placebo group; however, after additional sessions, the placebo group tended to catch up. CONCLUSIONS: D-cycloserine augmentation has the potential to increase the efficiency, palatability, and overall effectiveness of standard exposure therapy for OCD. 相似文献
103.
Jong S. Kim 《Journal of the neurological sciences》1996,140(1-2):123-128
Bilateral perioral sensory dysfunction due to unilateral cerebral lesion is rare, and has been thought to be caused by midline brainstem lesions. Six patients are described herewith, with bilateral perioral sensory symptoms due to unilateral strokes that do not involve the mid-brainstem region. Brain-computed tomographic scan and magnetic resonance imaging demonstrated unilateral cerebral strokes in the thalamus, posterior limb of the internal capsule, basal ganglia, fronto-parietal cortex and the insular-frontal subcortical area. This observation suggests that bilateral perioral sensory symptoms do not have a localizing value. Possible pathogenetic mechanisms for this sign are discussed. 相似文献
104.
目的:探讨老年精神科病人躯体疾病共病情况及其意义。方法:调查217例老年精神科病人的精神科诊断及合弄躯体疾病情况。结果:88.9%的病人合并有躯体疾病,每一个病人合并的躯体疾病的病种数平均为2.18种。合并的躯体疾病多见的是脑血管病、高血压、心脏病、感染、糖尿病、慢性阻塞性肺疾病(COPD)等。结论:老年精神科病人的躯体共病现象具有普遍性,其躯体疾病分布具有普通老年科病人的特点。躯体共病影响精神疾病的疗效预后及老年精神科的临床工作模式。 相似文献
105.
Emine Sözeri Dietrich Feist Hans Ruder Karl Schärer 《Pediatric nephrology (Berlin, Germany)》1997,11(3):307-311
Renal lesions have repeatedly been described in Wilson’s disease (WD). We investigated the excretion of total protein, albumin,
low (LMW) and high molecular weight (HMW) proteins, N-acetyl-β-D-glucosaminidase (NAG), and calcium, as well as creatinine clearance, in 24-h urine samples of 41 patients with WD aged 6 – 37
(mean 17) years who had been treated for a period of 0 – 15 (mean 4.5) years with D-penicillamine (900 mg/day). The amount of all protein excreted was significantly increased compared with controls, 39% of
patients presenting with total proteinuria more than two standard deviations from the mean of controls. The changes in protein
excretion depended on the duration of treatment. LMW proteinuria was elevated almost exclusively in the first 2 years after
the start of treatment, indicating early tubular damage. This is supported by an initially high excretion of β2-microglobulin, NAG, and calcium. Increased excretion of HMW proteins, including albumin, persisted over longer periods, which
suggests glomerular injury in some patients, possibly related to the use of D-penicillamine. Creatinine clearance remained roughly within normal limits. We propose that renal function should regularly
be checked in patients with WD.
Received October 26, 1995; received in revised form August 27, 1996; accepted September 20, 1996 相似文献
106.
This study investigated preferential encoding of threat material in subjects with posttraumatic stress disorder (PTSD) with a modified dot-probe paradigm. This paradigm indexes attentional bias by measuring response latency to name neutral target words that are presented adjacent to or distant from threat words. Motor vehicle accident survivors with PTSD (n = 15), subclinical PTSD (n = 15), and low anxiety (n = 15) were required to name target words that were presented either adjacent to or distant from strong threat, mild threat, positive, and neutral words. PTSD subjects named targets faster when they were in close proximity to mild threat words. Results suggested that PTSD subjects' attention was drawn to the mild threat stimuli and are discussed in the context of network models of PTSD. 相似文献
107.
Kelvin L Chou Maria L Moro-De-Casillas Melissa M Amick Leora L Borek Joseph H Friedman 《Movement disorders》2007,22(3):411-414
We examined the relationship between testosterone levels, violent dreams, and REM sleep behavior disorder (RBD) in 31 men with Parkinson's disease (PD): 12 with clinical RBD and 19 without. All PD patients with clinical RBD experienced violent dreams, but none of the 19 non-RBD patients reported violent dreams. While dream content appears to be more aggressive in PD patients with clinical RBD, the presence of violent dreams or clinical RBD is not associated with testosterone levels in men with PD. 相似文献
108.
Jacqueline Barnes 《Child and Adolescent Mental Health》1997,2(4):163-169
There is increasing interest in the influence of community characteristics on child development and family functioning. In order to address questions on community influence, it is important to be aware of the measures available and their strengths and limitations. Useful strategies have been developed within a number of disciplines, including sociology, social and community psychology, and criminology. Methods include summarising information from existing administrative databases and census data, conducting observations, and using survey instruments with residents. The most commonly used methods are reviewed and their psychometric properties described . 相似文献
109.
D. Bakish C. L. Hooper D. L. West C. Miller A. Blanchard F. Bashir 《Human psychopharmacology》1995,10(2):105-109
This retrospective study was undertaken with the objective of determining how effective and safe moclobemide, a specific and reversible inhibitor of monoamine oxidase-A (RIMA), is when used in combination with specific serotonin re-uptake inhibitors (SSRIs), in a clinical setting. A thorough chart review was done of all patients with affective and anxiety disorders seen at our centre who received combination treatment with moclobemide and an SSRI. Combination moclobemide-SSRI treatment demonstrated good efficacy in treating treatment-resistant patients. The combination treatment was well tolerated with very few drug interactions. Dosages should be started low, titrated slowly and carefully, and patients should be monitored closely. 相似文献
110.
综述了老年人睡眠质量及其影响因素、睡眠障碍的危害、老年病人睡眠的护理干预。建议进行前瞻性干预试验,为改善老年人的睡眠质量提供依据。 相似文献