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排序方式: 共有490条查询结果,搜索用时 15 毫秒
11.
Arunabha Ganguly Myron H. Weinberger John M. Passmore John A. Caras Rashid M. Khairi Clarence E. Grim James Edmonson C.Conrad Johnston 《Metabolism: clinical and experimental》1982,31(6):595-600
To evaluate the role of the renin-angiotensin-aldosterone system in the hypertension associated with primary hyperparathyroidism, we measured plasma renin activity and aldosterone concentration before and after maneuvers to suppress and stimulate this system in 11 hypertensive patients with primary hyperparathyroidism. We also measured plasma or urinary norepinephrine concentration to examine the role of catecholamines in the hypertension. The results were compared with an age- and race-matched control population. While the mean plasma aldosterone concentrations were normal, the mean plasma renin activity in response to furosemide stimulation was subnormal in subjects with hyperparathyroidism. Plasma or urinary norepinephrine concentrations were within the normal range. Thus a specific abnormality of the renin-angiotensin-aldosterone system or catecholamines could not be identified in these hypertensives with primary hyperparathyroidism. 相似文献
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Joiner WM Lee JE Shelhamer M 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2007,181(2):307-320
The ability to make predictive saccadic eye movements is dependent on neural signals that anticipate the onset of a visual
target. We used a novel paradigm—based on the saccade-countermanding task—as a tool to investigate rhythm saccade pacing and
to provide information on the mechanisms of predictive timing. In particular, we examined the ability of normal subjects to
stop a sequence of periodically paced eye movements when cued by a stop signal that was presented at different times with
respect to the last target of the sequence (stop signal delay, SSD). The timing of the stop signal affected the ability to
stop the saccadic sequence (make a saccade to a central target rather than to the peripheral alternating targets) in different
ways, depending on the preceding tracking behavior. For the same SSD, subjects cancelled fewer trials during predictive tracking
(promoted by tracking targets alternating at a fast pacing rate, 1.0 Hz) than during reactive tracking (tracking alternating
targets at a low pacing rate, 0.2 Hz). In addition, on non-canceled trials, there was an increase in the delay of the corrective
saccade to the central target with increasing SSD for pacing at 0.2 Hz, but the timing of the corrective saccade remained
near constant for 1.0 Hz pacing. In examining the timing between movements, we estimate that the repetitive GO process that
drives the saccades during predictive tracking begins earlier and has a shorter duration than the repetitive GO process during reactive tracking. These behavioral results provide further insight into the initiation process of predictive responses. In particular,
the reduced reaction time and the corresponding short duration of the predictive process may result from a faster accumulation
of neuronal discharge to a relatively fixed threshold. 相似文献
15.
Lauren T. Ptomey Felicia L. Steger Jaehoon Lee Debra K. Sullivan Jeannine R. Goetz Jeffery J. Honas Richard A. Washburn Cheryl A. Gibson Joseph E. Donnelly 《Journal of the Academy of Nutrition and Dietetics》2018,118(6):1087-1096
Background
Previous research indicates that individuals with intellectual and developmental disabilities (IDDs) are at risk for poor diet quality.Objective
The purpose of this secondary analysis was to determine whether two different weight-loss diets affect energy intake, macronutrient intake, and diet quality as measured by the Healthy Eating Index-2010 (HEI-2010) during a 6-month weight-loss period and 12-month weight-management period, and to examine differences in energy intake, macronutrient intake, and HEI-2010 between groups.Design
Overweight/obese adults with IDDs took part in an 18-month randomized controlled trial and were assigned to either an enhanced Stop Light Diet utilizing portion-controlled meals or a conventional diet consisting of reducing energy intake and following the 2010 Dietary Guidelines for Americans. Proxy-assisted 3-day food records were collected at baseline, 6 months, and 18 months, and were analyzed using Nutrition Data System for Research software. HEI-2010 was calculated using the data from Nutrition Data System for Research.Participants/setting
The study took place from June 2011 through May 2014 in the greater Kansas City metropolitan area.Main outcome measures
This was a secondary analysis of a weight-management intervention for adults with IDDs randomized to an enhanced Stop Light Diet or conventional diet, to examine differences in energy intake, macronutrient intake, and HEI-2010 across time and between groups.Statistical analyses performed
Independent- and paired-samples t tests and general mixed modeling for repeated measures were performed to examine group differences and changes at baseline, 6 months, and 18 months between the enhanced Stop Light Diet and conventional diet groups.Results
One hundred and forty six participants (57% female, mean±standard deviation age=36.2±12.0 years) were randomized to either the enhanced Stop Light Diet or conventional diet group (77 enhanced Stop Light Diet, 69 conventional diet) and provided data for analysis at baseline, 124 completed the 6-month weight-loss period, and 101 completed the 18-month study. Participants on the enhanced Stop Light Diet diet significantly reduced energy intake at 6 and 18 months (both P<0.001), but those on the conventional diet did not (both P=0.13). However, when accounting for age, sex, race, education level, and support level (mild vs moderate IDD), there was a significant decrease during the 18-month intervention in energy intake for the enhanced Stop Light Diet and conventional diet groups combined (P<0.01 for time effect), but no significant group difference in this change (P=0.39 for group-by-time interaction). There was no significant change in total HEI-2010 score at 6 and 18 months (P=0.05 and P=0.38 for the enhanced Stop Light Diet group; P=0.22 and P=0.17 for the conventional diet group), and no significant group difference at 6 and 18 months (P=0.08 and P=0.42). However, when participants’ age, sex, race, education level, and support level were accounted for, mixed modeling indicated a significant increase in total HEI-2010 scores for the enhanced Stop Light Diet and conventional diet groups combined during the 18-month intervention (P=0.01 for time effect).Conclusions
The results of this study found that after controlling for demographic factors, individuals with IDDs can decrease their energy intake and increase their diet quality, with no significant differences between the enhanced Stop Light Diet and conventional diet groups. 相似文献16.
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《Journal of emergency nursing》2020,46(2):154-162
IntroductionThe American College of Surgeons’ Stop the Bleed program has trained more than 1 million individuals to recognize and treat external hemorrhage. Central to this training is tourniquet application. No published studies review the retention of this skill after initial class participation.MethodsOne hundred fourteen volunteers agreed to participate. A random sample of 57 was selected and 46 participated. Upon return 6 months later, each participant demonstrated tourniquet application. An observer compared the application process with steps on a checklist. Each step completed correctly was tallied, and the total score for all 10 steps was computed as a percentage correct between 0% and 100%.ResultsThe baseline score on the tourniquet skill test was 100% following initial training. At 6 months, mean scores were lower, 69% (SD = 31%) (χ2 = 52.09, df = 1, P < 0.001). Fourteen volunteers (30%) attained a score of 100%, and 28 volunteers (61%) achieved a passing score. Bleeding was stopped or reduced to non–life-threatening levels by 34 participants (74%). Participants with passing scores were more likely to stop or reduce the bleeding than those with failing scores (97% vs 35%; χ2 = 20.99, df = 1, P < 0.001). Of the 17 volunteers who failed, 18% stopped the bleeding, 18% slowed bleeding to a non–life-threatening level, and 64% were unable to control bleeding.DiscussionAt 6 months, 39% of participants were unable to successfully apply a tourniquet, and 26% were unable to control life-threatening bleeding. This study demonstrates that refresher training is needed within 6 months of initial training. 相似文献
18.
A Study of Ser217Leu and Ala541Thr Polymorphism in the Men Afflicted with Prostate Cancer and in the Men being Suspicious of Prostate Cancer 下载免费PDF全文
Zahra ZahiriFatemeh Zahiri 《Asian Pacific journal of cancer prevention》2020,21(6):1551-1557
Background and objective: Prostate cancer is one of the most widespread cancers among men throughout the world. In addition, it is the second cause of death after lung cancer. Occurrence of the prostate cancer is variable in various regions of the world. Solely, there are three known risk factors for the prostate cancer, including: Age, inheritance and ethnic origin. ELAC2 protein is a phosphodiesterase enzyme encoded by ELAC2 gene in human. This gene is placed on chromosome 17, and it is believed that product of the mentioned gene is an endonuclease contributed in puberty of mitochondrion’s tRNA. From clinical viewpoint, variables of ELAC2 gene such as Ser217Leu and Ala541Thr Missense mutations which are accompanied by hereditary prostate cancer (HPC2).Objective of this study is to investigate Ser217Leu (rs4792311) and Ala541Thr (rs5030739) polymorphisms in the individuals with prostate cancer or those who are suspicious of prostate cancer with family past record/history. Study method: In this study conducted by case-control method in 2018, 102 men with prostate cancer and 98 men being suspicious of prostate cancer out of 10 families referred to shahid Rajaei Hospital in Tonekabon county to study and check were investigated. After collection of data using questionnaire, sampling from individuals and performance of the rest steps, study of polymorphism was carried out by PCR sequencing technique, and the results were analyzed by Chromas software. Finding: Of the total studied 102 individuals, 44 individuals (43.1%) were homozygote for Ser217Leu mutation, 36 individuals (35.2%) were heterozygote and 22 individuals (21.5%) lacked Missense mutation. for Ala541Thr mutation, 18 ones (17.6%) were heterozygote and 84 ones (82.3%) lacked Missense mutation. For Ser217Leu mutation, out of 98 suspicious individuals, 21 individuals (21.4%) were homozygote. 6 individuals (6.1%) were heterozygote and 71 individuals (72.4%) lacked the mutation. For Ala541Thr mutation, 15 ones (15.3%) were homozygote and 84 ones (84.6%) lacked the studied mutation. Conclusion: Results of this research showed that, in the individuals with the prostate cancer, there is a relationship between Ser217Leu and Ala541Thr polymorphism of ELAC2 gene and/with prostate cancer, and the suspicious individuals gotten involved in the mutation must take action to prevent this cancer. 相似文献
19.
RhoA和肌球蛋白轻链在肝纤维化大鼠肝组织中的表达 总被引:5,自引:0,他引:5
目的观察Rho/Rho激酶信号转导通路关键信号分子RhoA和磷酸化肌球蛋白轻链[p-MLC(Thr18/Ser19)]在大鼠肝纤维化组织中的表达规律。方法HE及Masson三色染色观察肝病理组织学变化;用Western blot检测RhoA、p-MLC(Thr18/Ser19)蛋白的表达;RT-PCR方法检测RhoAmRNA的表达。结果随着肝纤维化的进展,RhoA、p-MLC(Thr18/Ser19)蛋白表达明显增加,RhoAmRNA基因表达也逐渐加强。RhoA和p-MLC(Thr18/Ser19)分别与α-平滑肌肌动蛋白(α-SMA)呈显著正相关。结论Rho/Rho激酶信号转导通路在肝纤维化形成过程中发生变化。 相似文献
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