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81.
Ronald Rosengart Michael Fishbein George C. Emmanouilides 《The American journal of cardiology》1975,35(1):107-111
Severe pulmonary vascular disease developed 1 year after a Mustard operation in a year old boy with transposition of the great arteries and intact ventricular septum. The possible etiologic factors responsible for the development of pulmonary vascular disease are discussed, and it is suggested that this disturbing late postoperative complication may occur more frequently than is recognized. 相似文献
82.
P.J. Collipp V. Curti J. Thomas R.K. Sharma V.T. Maddaiah S.H. Cohn 《Metabolism: clinical and experimental》1973,22(4):589-595
Skinfold thickness was found to decrease during the first 6–10 wk and then remain constant when human growth hormone therapy was begun in 34 growth hormone-deficient children. Linear growth increased at a constant rate during the first 6 mo. Two children, who routinely received their injection in the same arm at the same site, developed a localized area of markedly diminished subcutaneous fat at the injection site, Height, weight, total-body potassium, and triceps skinfold thickness were measured at 2-mo intervals in nine children receiving human growth hormone. Total-body potassium was measured with the 54-Nal detector whole-body counter of the Brookhaven National Laboratory. The study extended over a period of 20 consecutive mo. Triceps skinfold thickness rapidly decreased during the initiation of therapy with growth hormone, and returned to pretreatment values during a 5-mo control period when therapy was temporarily discontinued. Rate of weight gain was most rapid during this 5-mo control period and was reduced during two periods when growth hormone was being administered. Total body potassium and height increased very little during the control period when weight gain was greatest, and both increased rapidly during the two periods of growth hormone treatment. The data show clearly the initial changes in body fat and lean tissue that occur when human growth hormone is administered to children with growth deficiency. 相似文献
83.
The effects of short-term (7 days) administration of dichloroacetate (DCA) on carbohydrate and lipid metabolism in the Zucker obese and lean rat were investigated. Metabolic effects of the drug were more pronounced in the obese than in the lean rat. DCA decreased fasting blood glucose concentrations in both lean and obese rats, but more so in the fat animals, probably because of higher initial levels. The hypoglycemic action of DCA is likely attributable to a direct effect on liver and peripheral tissues and not to an indirect action caused by a decrease in the glucagon-to-insulin ratio because the drug induced just the opposite effect. DCA decreased plasma triglycerides (TG) and free fatty acids (FFA) in the hyperlipemic rats but not in lean rats. Intrahepatic triglyceride content diminished after drug treatment in fat rats, suggesting decreased hepatic TG synthesis. Hyperketonemia, induced in both lean and fat rats by DCA treatment, was also greater in the obese animal. This response was probably caused by accelerated hepatic ketone body production due to increased β-oxidation, and not to enhance FFA substrate supply. These data demonstrate that DCA is capable of correcting many of the underlying abnormalities in carbohydrate and fat metabolism in the obese Zucker rat. 相似文献
84.
85.
Testicular torsion is a surgical emergency and requires prompt recognition and treatment. Health care personnel often forget this differential diagnosis in males who present with abdominal pain as their only complaint. There is a 4- to 6-hour window from the onset of symptoms to the surgical intervention to salvage the testes. It is imperative for health care personnel to consider testicular torsion in any male presenting with abdominal pain and to complete a genitourinary examination. The purpose of this case review is to highlight the importance of a genitourinary examination in recognizing testicular torsion. 相似文献
86.
《Clinical neurophysiology》2021,132(3):765-769
ObjectiveTo measure inter- and intra-rater agreement in the interpretation of cortical somatosensory evoked potential (SSEP) components following paediatric cardiac arrest (CA) in multi-professional neurophysiology teams.MethodsThirteen professionals blinded to patient outcome interpreted 96 SSEPs in paediatric patients 24-/48-/72-hours following CA. Of these, 34 were duplicates used to assess intra-rater agreement. Consistent interpretations (absent/present/indeterminate) between scientists (who record/identify SSEP components) and neurophysiologists (who provide prognostic SSEP interpretation) were expressed as percentages. Rates of agreement were calculated using Fleiss’ kappa coefficient (K).ResultsUnanimous agreement between professionals was present in 40% (95%CI: 28–54%) of the interpreted SSEPs, with a K value of 0.62 (95%CI: 0.55–0.70) based on average agreement. Agreement was similar between neurophysiologists (K = 0.67; 95%CI: 0.57–0.77) and scientists (K = 0.62; 95%CI: 0.54–0.70) but lower in patients < 2 years old (K = 0.23; 95%CI: 0.14–0.33) and in those with poor outcome (K = 0.21; 95%CI: 0.07–0.35). No SSEP was unanimously interpreted as absent and 92% (95%CI: 89–95%) of duplicate SSEPs were interpreted consistently.ConclusionDespite substantial agreement when interpreting prognostic SSEPs, this was significantly lower in children with poor outcome and of younger age.SignificanceClinicians using SSEPs in the intensive care unit should be aware of the inter-rater variability when interpreting SSEPs as absent. 相似文献
87.
Melanie Marsh Stephanie M. Lauden John D. Mahan Lydia Schneider Laura Saldivar Nina Hill Christopher Diaz Mahmoud Abdel-Rasoul Suzanne Reed 《Patient education and counseling》2021,104(5):1200-1205
ObjectiveThere are few opportunities in medical education dedicated to learning skills for effective communication in life altering patient scenarios. We therefore aimed to develop and assess a longitudinal advanced communication curriculum for pediatric residents using patient feedback and deliberate practice.MethodsPediatric residents at a large academic center were randomized into 2 groups. The intervention group received 6 educational sessions from 2019 to 2020, parent feedback of performance via the Communication Assessment Tool (CAT), and monthly communication tips. Communication skills of both groups were assessed at the end of the intervention.ResultsWe collected 937 CAT assessments on 36 first-year residents. The intervention group demonstrated statistically significant improvement in communication skills from pre to post assessment (p = 0.0063, (odds ratio (OR) 1.76, 95 % confidence interval (CI) [1.17, 2.63]) compared to the control group (p = 0.080, OR 1.41, 95 % CI [0.96, 2.05]).ConclusionsThere are patient and self-identified performance gaps in communication skills for pediatric residents, underscoring the need for formalized curricula dedicated to these skills.Practice implicationsOur study highlights the value of deliberate practice and the integration of family feedback as an educational tool in communication skills development. 相似文献
88.
89.
目的 探讨模拟演练干预在儿科实习护生应对医院暴力能力中的应用效果。方法 采用随机数字表法将在儿科实习的68名护生随机分为观察组和对照组,每组34例,对照组采用常规护理教学方式,观察组在对照组基础上实施模拟演练干预。干预1个月后,采用模拟教学评价量表、实习护生工作场所暴力管理能力量表对其进行效果评价。结果 干预后观察组儿科实习护生模拟教学评价量表总分及各维度得分、实习护士工作场所暴力管理能力量表总分及各维度得分均高于对照组(P<0.001)。结论 模拟演练干预方法能够有效提高儿科实习护生应对医院暴力能力,同时也提高了儿科护理教学水平,护生满意度上升。 相似文献
90.
Fabrizio Drago Massimo Stefano Silvetti Antonella De Santis Giorgia Grutter Peter Andrew 《Journal of interventional cardiac electrophysiology》2006,16(3):191-198
Introduction Cryoablation is an effective treatment for children with supraventricular tachycardias (SVT). The present study documents
the effect of two different cryoablation protocols on acute and chronic success rates.
Methods and results Fifty-three consecutive patients (age range, 5–20 years) were treated; patients 1 to 17 were treated by a standard ablation protocol and patients 18 to 53 were treated by a modified ablation protocol that required lengthier cryoablations plus delivery of a bonus cryoapplication to consolidate the acutely successful irreversible lesion created at intervention. Electrophysiological study
(EPS) was performed with diagnostic catheters and cryoablations were performed with a 7FR 4 mm tip catheter (CryoCath Technologies).
Acute endpoints for non-inducibility of atrioventricular nodal re-entrant tachycardia (AVNRT) by programmed atrial stimulation
at baseline or during isoproterenol performed 30 min post procedure, as well as non-inducibility and conduction block over
the accessory pathway (AP). The chronic endpoint was arrhythmia recurrence post intervention. No permanent cryo-related complications
or adverse outcomes were reported. Acute success rates for patients 1 to 17 and 18 to 53 were 88 and 100%, respectively. The
cumulative percentage of patients without arrhythmia recurrence at 12 month follow-up was significantly different at 73 and
90%, respectively.
Conclusions Lengthier cryoablation delivery, approximating 7 min per cryoablation, increases the acute success rate at intervention. Moreover,
these lengthier cryoablation deliveries plus a bonus cryoapplication to consolidate the acutely successful irreversible lesion
created at intervention may also significantly improve the chronic success rate, while also maintaining an excellent safety profile for cryoablation
treatment of children with SVT such as AVNRT and AP located near the AV junction. 相似文献