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991.
心脏病患者血清七种元素含量与血压及生化指标的关系 总被引:31,自引:0,他引:31
我们检测了心脏病患者血清微量元素Zn、Cu、Fe和常量元素K、Na、Ca、Mg的含量,并与血压及生化指标作相关分析。结果发现心脏病患者K和Ca/Mg显著低于对照组,而Na、Mg、Zn、Fe和Na/K、Zn/Cu则显著高于对照组。K、Ca/Mg与血压呈负相关,而Na、Zn、Fe、Zn/Cu和Na/K与血压呈正相关;Fe与红细胞压积(Hct)呈正相关;Zn/Cu与Hct、甘油三酯、极低密度脂蛋白均呈正相关,而与高密度脂蛋白呈负相关。 相似文献
992.
本文对300例肛肠疾病采用CO_2激光治疗,治愈率为94.33%,一次切割完成,不需止血缝合,一般7-15天痊愈,疗效明显优于其它治疗方法。 相似文献
993.
J. A. Doebler W. R. Markesbery A. Anthony S. W. Scheff R. E. Rhoads 《Acta neuropathologica》1988,75(3):272-276
Summary A new double-staining procedure, in which the techniques of immunocytochemistry of glial fibrillary acidic protein (GFAP) and quantitative microdensitometry of azure B-RNA were combined, was used to study nucleic acid alterations in fibrous astrocytes in Alzheimer's disease (AD). RNA contents of GFAP-positive cells of the hippocampal endplate (Rose's H3-H5 fields) and the dentate gyrus molecular layer were determined in ten autopsy-proven AD patients (ages 51–88) and ten age-matched, non-demented control. In addition, RNA contents of pyramidal neurons of the endplate were examined. While there were no differences in RNA contents of astrocytes of either region between AD patients and controls, neuronal RNA was markedly depleted. These data suggest that astrocytes maintain protein synthetic capabilities in AD and that RNA loss is limited to the neuronal compartment.Supported by Grants 1P01-AG05119 and 1P50-AG05144 from the National Institutes of Health and by a Small Research Project Award from the University of Kentucky Medical Center 相似文献
994.
J. de Pedro-Cuesta L. Widén-Holmqvist P. Bach-y-Rita 《Acta neurologica Scandinavica》1992,86(5):433-439
In all, 22 reports of 20 randomized, controlled rehabilitation studies were evaluated. In 18 of these, the design of the trial was parallel, with a cross-over format being employed in the remaining 2 instances. Seven studies related to intensive rehabilitation during the early post-acute period. In six others, specific techniques--sometimes associated with traditional physiotherapy procedures--were compared: biofeedback, perceptual retraining, and amphetamine treatment. Eight experiments evaluated speech therapy in aphasia. Frequently, methodological considerations limited the interpretation of the results. The review showed that: 1) as regards activities of daily life and motor function, differences as between rehabilitation in stroke units on the one hand and non-rehabilitation or rehabilitation in medical wards on the other, were detected in relatively few quality studies and remained particularly inconclusive insofar as life in the home environment was concerned; 2) rehabilitation for aphasia and perceptual dysfunction proved effective for at least several months after acute stroke; 3) in general, examination of the reports cited revealed no differences in the effects of biofeedback and perceptual retraining vs conventional physiotherapy; 4) rehabilitation, whether administered by specialists or amateur caregivers purpose-trained by specialists, proved equally effective for aphasia. These conclusions constitute a valuable basis for the development and evaluation of modern rehabilitation programs for stroke patients. 相似文献
995.
Johannes Reim Kevin McIntosh Stephen Martin Drachman Daniel B. 《Journal of neuroimmunology》1992,41(1):61-70
The pathogenesis of myasthenia gravis (MG) involves a T cell-dependent antibody-mediated autoimmune response directed against acetylcholine receptors (AChR). Inactivation of AChR-specific T cells should interrupt the immune response, resulting in therapeutic benefit. Since each individual's repertoire of T cells responds to a heterogeneous and unique spectrum of AChR epitopes presented in association with self-major histocompatibility complex (MHC) class II, an individualized approach is required to target all relevant AChR-specific T cells. The individual's own antigen-presenting cells (APC) can be used for this purpose, since they process and present the antigen appropriately, and express the correct MHC class II. A novel method of binding AChR to surface immunoglobulin with a heterobifunctional antibody conjugate allows us to use all B cells as APC. Conjugate-plus-AChR-treated B cells (AChR-APC) effectively targeted AChR-specific T cells, stimulating vigorous proliferative responses in a rat cell culture system. If APCs are 'fixed' with cross-linking reagents, they induce long-lasting or permanent 'anergy' of the specific T cells. We prepared AChR-APC, allowed them to process AChR in vitro, and fixed them with paraformaldehyde. Pre-culture of these fixed AChR-APC with AChR-specific T cells induced anergy: when restimulated with fresh AChR-APC, the T cells exhibited markedly reduced proliferative responses and IL-2 production, compared with responses of T cells pre-cultured with control fixed B cells. Implications for the design of antigen-specific therapeutic strategies for MG and other immune disorders will be discussed. 相似文献
996.
This study compares the histology of the plantar-digital nerve supplying the third web space in asymptomatic patients with those who have clinically diagnosed Morton's metatarsalgia. Despite several studies concentrating on the histological changes in the interdigital nerve, the relevance of these changes is a matter of contention while the exact pathological process responsible for the symptoms has not been determined. The histological findings in control patients were identical to Morton's patients with the exception of demyelination, which was more common in the Morton's group. This suggests that the characteristic nodule and fibrotic changes seen in the interdigital nerves of patients with Morton's neuroma cannot account for the symptoms and that the changes seen in the neurovascular bundle are degenerative in origin and are found in asymptomatic patients. 相似文献
997.
载脂蛋白B信号肽序列多态性及其与冠心病的关联 总被引:4,自引:0,他引:4
应用聚合链反应(PCR)对103例冠心病人及100名正常人载脂蛋白B(apoB)基因5'端信号肽序列的多态性研究结果表明:(1)中国人信号肽序列插入/缺失(Ins/Del)多态性频率分布与国外不同种族间有差异。少见Del等位基因相对频率为0.259,高于南亚人,但低于法国高加索人。(2)冠心病组与正常对照组间等位基因相对组间等位基因相对频率分布差异无显著意义。(3)冠心病组内具Del等位基因者血浆 相似文献
998.
小儿先心病术后左房夺和肺动脉压力的监测在ICU中十分重要。心电图是论断和评价心脏疾患的常用方法。本文分析了32例小儿先心病手术前后(伴肺动脉高压16例)6个肢体导联心电图中P波和QRS波时限总和及振幅总和与左房、肺动脉压力的关系。结果表明两者均有良好的相关性(r=0.85 ̄0.88,r=0m74 ̄0.80,P〈0.01),该法简单、方便,可广泛开展,尤其在术后未放置PA和LA管或在IOU中已拨除L 相似文献
999.
HIDEAKI SENZAKI MATSUKO SUDA SEIJI NOMA HARUO KAWAGUCHI YOICHI SAKAKIHARA TOSHIO HISHI 《Pediatrics international》1994,36(4):443-447
Acute renal failure and acute heart failure are rare in Kawasaki disease. We experienced two patients with Kawasaki disease who presented acute renal failure and acute heart failure. These two patients gave us an important insight into the understanding of water balance and fluid therapy in Kawasaki disease. One patient showed acute prerenal failure due to fluid exudation from the intravascular to the extravascular space, and subsequent acute heart failure. The other patient showed acute heart failure caused by fluid infusion for the treatment of dehydration. It is suggested that acute renal failure could be caused by a fluid shift from the intravascular to the extravascular space in Kawasaki disease. It is also demonstrated that the reserve of cardiac function could be decreased in patients with Kawasaki disease due to myocarditis even with normal echocardiography and chest X-rays. 相似文献
1000.
J. A. P. van de Nes A. A. Sluiter C. W. Pool W. Kamphorst R. Ravid D. F. Swaab 《Brain research》1994,655(1-2)
The monoclonal antibody Alz-50 is directed against Alzheimer's disease-related modified tau proteins and reveals cytoskeletal changes, i.e. neurofibrillary tangles and dystrophic neurites. The present study shows that, in the hypothalamus of non-demented control subjects, this same antibody gives a distinctive staining pattern of a subpopulation of somatostatin neurons and beaded fibers. Furthermore, Alz-50 occasionally recognizes somatostatin-containing cell bodies and dystrophic neurite-like fibers in the (neuritic) senile plaques of AD patients. These observations have direct consequences for the interpretation of Alz-50 staining in diagnostic usage and for the assessment of Alzheimer's disease-like changes induced by β-amyloid in experimental animal brains. On dot spotting, Alz-50 was found to bind to a number of fragments from the somatostatin precursor, of which somatostatin15–28 stained best. Preadsorption of Alz-50 by somatostatin15–28, as well as other specificity tests, failed, however, to provide any clue to the nature of the unknown compound(s) stained in the control hypothalamus. 相似文献