全文获取类型
收费全文 | 12240篇 |
免费 | 343篇 |
国内免费 | 354篇 |
专业分类
耳鼻咽喉 | 155篇 |
儿科学 | 169篇 |
妇产科学 | 229篇 |
基础医学 | 1088篇 |
口腔科学 | 220篇 |
临床医学 | 1067篇 |
内科学 | 2395篇 |
皮肤病学 | 143篇 |
神经病学 | 1551篇 |
特种医学 | 404篇 |
外科学 | 888篇 |
综合类 | 768篇 |
现状与发展 | 1篇 |
一般理论 | 4篇 |
预防医学 | 839篇 |
眼科学 | 420篇 |
药学 | 1331篇 |
18篇 | |
中国医学 | 678篇 |
肿瘤学 | 569篇 |
出版年
2024年 | 5篇 |
2023年 | 334篇 |
2022年 | 806篇 |
2021年 | 1184篇 |
2020年 | 1227篇 |
2019年 | 1531篇 |
2018年 | 1391篇 |
2017年 | 994篇 |
2016年 | 701篇 |
2015年 | 366篇 |
2014年 | 628篇 |
2013年 | 1394篇 |
2012年 | 1215篇 |
2011年 | 243篇 |
2010年 | 174篇 |
2009年 | 68篇 |
2008年 | 55篇 |
2007年 | 45篇 |
2006年 | 40篇 |
2005年 | 33篇 |
2004年 | 15篇 |
2003年 | 13篇 |
2002年 | 6篇 |
2001年 | 17篇 |
2000年 | 18篇 |
1999年 | 9篇 |
1998年 | 7篇 |
1997年 | 2篇 |
1996年 | 8篇 |
1995年 | 11篇 |
1994年 | 12篇 |
1993年 | 5篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 4篇 |
1988年 | 1篇 |
1986年 | 2篇 |
1985年 | 72篇 |
1984年 | 35篇 |
1983年 | 45篇 |
1982年 | 45篇 |
1981年 | 40篇 |
1980年 | 31篇 |
1979年 | 24篇 |
1978年 | 21篇 |
1977年 | 12篇 |
1976年 | 10篇 |
1975年 | 18篇 |
1974年 | 6篇 |
1973年 | 7篇 |
排序方式: 共有10000条查询结果,搜索用时 146 毫秒
11.
12.
13.
《Foot and Ankle Surgery》2020,26(2):193-197
BackgroundThe aim of this study was to compare the radiographic and functional results between fixation and non-fixation in the Cotton osteotomy for the treatment of adult acquired flatfoot.MethodsA retrospective, case-controlled study of consecutive stage IIB posterior tibial tendon dysfunction (PTTD) patients treated with the same bony reconstructive surgery including cotton osteotomy between 2013 and 2017. Meary’s angle, the medial arch sag angle (MASA), and medial cuneiform cobb angle (MCCA) were evaluated pre-operation, at first weight bearing after surgery, and 12 months post operation.ResultsForty feet were included in the study. The cotton osteotomy utilized screw fixation (n = 20) or non-fixation technique (n = 20). No significant differences between groups were found in pre-operative and follow-up radiographic parameters, union rate, and functional results.ConclusionThe non-fixation with press fit technique is a reliable procedure for Cotton osteotomy and as effective as screw fixation.Level of evidenceLevel III, case control study 相似文献
14.
15.
16.
《Clinical neurophysiology》2020,131(7):1444-1452
ObjectiveTo investigate cognitive functions in non-demented patients with early-onset Parkinson's disease (PD), and to compare PARK2 gene mutation carriers and non-carriers by means of event-related brain potentials (ERPs).MethodsThe participants comprised patients with early-onset PD (EOPD) and healthy controls (HC). Patients with EOPD were divided into two groups as carriers of known pathogenic variants of PARK2 gene (EOPD-PC) and non-carriers of genes involved in familial PD (EOPD-NC). ERP data were collected during auditory oddball and visual continuous performance test (CPT).ResultsBoth EOPD groups (EOPD-PC and EOPD-NC) displayed reduced and delayed P3 in response to oddball target and CPT NoGo. CPT Go P3 was reduced in EOPD-NC but not in EOPD-PC. Oddball target N1 was reduced and P2 was enhanced in both EOPD-PC and EOPD-NC. In both cognitive tasks, RTs were prolonged and accuracy was lower in EOPD-PC and EOPD-NC.ConclusionsWe found several EOPD-related neurophysiologic changes, implying impairments in cognitive functions. Pairwise comparisons between EOPD-PC and EOPD-NC revealed no significant ERP marker.SignificanceIn this study, the confounding effect of normative aging was somewhat excluded compared with many previous studies. In contrast with the many oddball studies in non-demented PD, we clearly observed reduced and prolonged P3 in early-onset PD. Our NoGo P3 findings also contribute to the limited ERP research concerning response inhibition. 相似文献
17.
Michelle E. Wilson Charles Kim Jacqueline Carrasco 《Orbit (Amsterdam, Netherlands)》2016,35(5):288-291
A 48-year-old smoker with a history of hyperthyroidism treated 10 years prior to presentation with radioactive iodine ablation of the thyroid gland presented to his ophthalmologist with a 2-week history of transient loss of vision in the right eye occurring for 1 to 2 hours each morning. He denied ocular pain, diplopia or change in the prominence of one or both eyes. Examination revealed 2 mm of relative proptosis on the right, bilateral temporal flare and lower lid retraction. There was minimal upper lid retraction and no evidence of lid lag. Ocular motility was full. Dilated fundoscopic examination revealed bilateral optic nerve edema, right more than left. CT of the orbit demonstrated enlargement of the extraocular muscles bilaterally with marked enlargement of the right medial rectus and left inferior rectus muscles resulting in crowding at the orbital apex bilaterally. Laboratory testing revealed the patient to be hyperthyroid. The patient was treated with high dose oral steroids followed by orbital radiation. Hyperthyroidism was managed by the patient’s primary care physician. Visual symptoms rapidly improved with oral steroids and orbital radiation. Optic nerve edema completely resolved. Repeat CT imaging demonstrated a reduction in the enlargement of the extraocular muscles with relief of bilateral optic nerve compression. 相似文献
18.
19.
20.
《Drug discovery today》2022,27(6):1733-1742
Compounds that exhibit assay interference or undesirable mechanisms of bioactivity are routinely encountered in assays at various stages of drug discovery. We observed that assays for the investigation of thiol-reactive and redox-active compounds have not been collected in a comprehensive review. Here, we review these assays and subject them to experimental optimization to improve their reliability. We demonstrate the usefulness of our assay cascade by assaying a library of bioactive compounds, chemical probes, and a set of approved drugs. These high-throughput assays should complement the array of wet-lab and in silico assays during the initial stages of hit discovery campaigns to pursue only hit compounds with tractable mechanisms of action. 相似文献