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31.
《Best Practice & Research: Clinical Haematology》2022,35(3):101386
Reports of racial and ethnic disparities regarding both rates of infection of the SARS-CoV-2 virus and morbidity of the coronavirus disease-19 (COVID-19) contain profound differences depending on the population. Our previous study has shown that patients with COVID-19 who developed hypertriglyceridemia during hospitalization have a 2.3 times higher mortality rate. However, whether the correlation between hypertriglyceridemia and mortality has disparity among different racial and ethnic groups is unknown.In this study, we investigated the impact of race/ethnicity on the correlation between hypertriglyceridemia and mortality in hospitalized patients with COVID-19. De-identified information from 904 hospitalized patients diagnosed with COVID-19 between March 2020 and June 2021 were extracted from the Medical College of Wisconsin Clinical Data Warehouse. A multivariable regression analysis suggested that the Asians and non-White Hispanics had 4 or 3.9 times higher mortality rate, respectively, after adjusting for age, morbid obesity (BMI ≥40), and gender. The hypertriglyceridemia (≥150 mg/dL) was associated with higher mortality, after adjusting for age, gender, and morbid obesity. The baseline hypertriglyceridemia occurrence had relevantly more consistent percentages among all racial/ethnic groups. However, non-White Hispanic and Asian patients had the highest frequencies of peak hypertriglyceridemia occurrence during hospitalization. The peak hypertriglyceridemia developed during hospitalization correlates with the incidence of thrombosis after adjusting for morbid obesity, age, and sex. In summary, in this retrospective study of 904 hospitalized COVID-19 patients, Asians and non-White Hispanics had a greater likelihood of developing hypertriglyceridemia during hospitalization and mortality than White patients. 相似文献
32.
目的探讨糖耐量减低(IGT)患者早期糖尿病肾病的预测指标、患病率及影响因素。方法262例受试者中正常糖耐量(NGT)103人、IGT98人、糖尿病(DM)61人,全部进行即刻尿转铁蛋白/肌酐(UTRF/Cr)和尿白蛋白/肌酐(UAlb/Cr)的检测及临床观察指标的测定。结果(1)UTRF/Cr与UAlb/Cr呈显著正相关,r=0.618,P<0.001。(2)IGT组的UAlb/Cr(中位数,极差)、UTRF/Cr(中位数,极差)高于NGT组(0.015,0.44mg/mg比0.012,0.58mg/mg,t=-1.981,P=0.049;0.064,4.96mg/mg比0.034,7.30mg/mg,t=-2.249,P=0.026)。(3)各组UTRF/Cr比值的阳性率明显高于白蛋白尿的阳性率(41.6%比29.7%,P(0.01)。(4)Logistic回归分析显示白蛋白尿的主要危险因素是DBP,OR=1.064,2hPGOR=1.109,P<0.01;非糖尿病组的主要危险因素是DBP,OR=1.064,P<0.01。结论在IGT阶段已存在早期糖尿病肾脏损害,高血压是其重要的危险因素。尿转铁蛋白/肌酐比值的检测较白蛋白尿/肌酐比值更灵敏,但仍需进一步综合比较二者的敏感性和特异性。 相似文献
33.
Ahlem Rafrafi Besma Chahed Safa Kaabachi Wajih Kaabachi Haifa Maalmi Kamel Hamzaoui Fayçal Haj Sassi 《Human immunology》2013
Interleukin 8 (IL-8), is a proinflammatory chemokine, has been reported to have angiogenic activity and to be responsible for tumor-associated angiogenesis in several cancers. In this study, we aimed to study the (IL-8) gene polymorphism in relation with risk development of non small cell lung cancer in Tunisian patient. Two single nucleotide polymorphisms (−251T/A [rs4073], +781C/T [rs2227306]) of the IL-8 gene were screened in 170 patients with NSCLC and 225 healthy controls by PCR–RFLP. 相似文献
34.
You-Shyang Chen 《Computers in biology and medicine》2013,43(10):1590-1605
Healthcare problems observed in the majority of end-stage renal disease (ESRD) patients regarding hemodialysis (HD) treatment are serious issues for the Taiwanese healthcare services, and an interesting topic is thus the adequacy of HD therapy. This study successfully models a hybrid procedure to measure HD adequacy to assess therapeutic effects and to explore the relationship between accuracy and coverage for interested parties. The proposed model has better accuracy, a lower standard deviation, and fewer attributes than the listed methods under various evaluation criteria. The study results are useful to subsequent researchers to develop suitable applications, and to ESRD patients and their doctors to ensure satisfactory medical quality. 相似文献
35.
《Annals of human biology》2013,40(5):372-381
Background: Although Tanner was not directly involved in physical education or the sport sciences, several of his papers addressed issues related to research in the area. Aim: To consider the implications of selected papers and research projects for the sport sciences. Papers and Implications: Several early papers addressed ratio standards, somatotype and total cholesterol, and anthropometric and somatotype changes associated weight training and cessation of training in young adult men. The papers have, respectively, implications for current studies of allometric scaling, physique and risk factors for cardiovascular and metabolic complications, and responses to training. The survey of athletes at the 1960 Rome Olympic Games not only added to the literature but to some extent also set the stage for subsequent surveys of Olympic athletes in 1968, 1972 and 1976. Although not directly involved in the mixed-longitudinal study of Training of Youth Athletes (TOYA) in several sports, it was conducted in his department. Results from TOYA indicated no influence of systematic training for sport on growth in height, young adult height and sexual maturation. Growth at Adolescence was also a fixture in many graduate programs. Conclusion: Though not a sport scientist, Tanner contributed directly and indirectly to the field. 相似文献
36.
《Pancreatology》2021,21(6):1112-1118
ObjectiveTo determine the risk association between fasting glucose levels and pancreatic cancer using systematically collected prediagnostic blood glucose samples.MethodsProspective nested case-control study of participants from the Northern Sweden Health and Disease Study, including 182 cases that developed pancreatic cancer and four matched controls per case. Blood glucose levels collected up to 24 years before pancreatic cancer diagnosis were analyzed. The association between fasting glucose levels and pancreatic cancer risk was determined using unconditional and conditional logistic regression models. The association between fasting glucose and the time to pancreatic cancer diagnosis, tumor stage and survival was determined using likelihood-ratio test, t-test and log rank test.ResultsThe unadjusted risk of developing pancreatic cancer increased with increasing fasting glucose levels (OR 1.30, 95% CI 1.05–1.60, P = .015). Impaired fasting glucose (≥6.1 mmol/L) was associated with an adjusted risk of 1.77 for developing pancreatic cancer (95% CI 1.05–2.99, P = .032). In subgroup analysis, fasting glucose levels were associated with an increased risk in never-smokers (OR 4.02, 95% CI 1.26–12.77, P = .018) and non-diabetics (OR 3.08, 95% CI 1.08–8.79, P = .035) (non-significant for interaction). The ratio between fasting glucose and BMI was higher among future pancreatic cancer patients and an increased ratio was associated with elevated risk of pancreatic cancer (OR 1.66, 95% CI 1.04–2.66, P = .034). Fasting glucose levels were not associated with TNM stage at diagnosis or survival.ConclusionsHigh fasting glucose is associated with an increased risk of being diagnosed with pancreatic cancer. 相似文献
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