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871.
872.
《Expert opinion on investigational drugs》2013,22(4):521-529
Background: Serious infections caused by Gram-positive bacteria, particularly multi-drug resistant, are an important cause of morbidity and mortality in patients admitted to intensive care units. Thus, new antibiotics covering these pathogens are urgently needed. Objective: To review characteristics of telavancin, a novel antibiotic intended to use for treating infections caused by difficult Gram-positive bacteria, such as Staphylococcus aureus, resistant to meticillin or vancomycin, multi-drug-resistant Streptococcus pneumoniae or glycopeptide-resistant enterococci. Methods: The studies on microbiological activity, clinical efficacy and safety of telavancin were reviewed. Results/conclusion: Telavancin is a lipoglycopeptide administered intravenously once-daily and excreted with urine. It proved to be microbiologically active against numerous Gram-positive pathogens including drug-resistant staphylococci, enterococci and pneumococci. Large randomized Phase II and III clinical trials on efficacy and safety of telavancin in treating complicated skin and skin structure infections reported telavancin to be non-inferior to standard treatment (mostly vancomycin). Preliminary data on telavancin in hospital-acquired pneumonia, including ventilator-associated pneumonia, documented that telavancin was efficacious for this indication. Overall incidence of adverse events was similar for telavancin and the comparator arms. Mild and transient disgeusia, nausea and vomiting resulted to be more frequent in telavancin group. Increase in creatinine values was also observed in telavancin arm. 相似文献
873.
《Expert review of cardiovascular therapy》2013,11(1):131-137
Cardiovascular diseases account for 20% of deaths worldwide, rising to 50% in developed countries. Current understanding of atherosclerosis derives from a combination of research in animals and cell cultures, analysis of human lesions, clinical investigations of patients with acute coronary syndromes and epidemiological studies of coronary artery disease. By measuring serologic titers in the serum of patients after cardiovascular events, it was observed that the greater the infectious exposure of a patient, the larger the atherosclerotic lesion extension. In addition, gene targeting or pharmacological inhibition of certain cytokines aggravates atherosclerosis in animal experiments. Other animal experiments have succeeded in proving that B cells play a protective role in atherosclerosis through induced immunity against oxidized low-density lipoprotein and other epitopes. Molecular mimicry might respond to the question of how infection may trigger vulnerability in previously stable atherosclerotic lesions. The FLU Vaccination Acute Coronary Syndromes trial enhanced the debate on atherosclerosis prevention by the application of antiflu vaccine. So far, antibiotics have failed to reduce cardiovascular risk, as recent trials could not demonstrate a statistically significant risk reduction. Having assumed atherosclerosis to be an inflammatory disease, the WHO considered the possible role of secondary prevention with antiflu vaccine. 相似文献
874.
《Journal of medical engineering & technology》2013,37(5):259-263
AbstractCatheter-related blood stream infections (CR-BSI) account for 30% of healthcare acquired infection (HAI). Colonization of connector hubs and contaminated syringes are thought to increase the risk of CR-BSI. The Coated Antiseptic Tip (CAT) syringe was developed to decontaminate connector hubs, thereby reducing the risk of CR-BSI. Needleless valves (n?=?20) and three-way connectors (n?=?20) were contaminated with common critical care pathogens. At hourly intervals, CAT syringes were inserted into the connector hubs and normal saline was injected through the connector. This was repeated with control (non-coated) syringes. The internal surface of the connector hubs were swabbed at t?=?0, t?=?1?h and t?=?4?h, inoculated onto blood agar plates and analysed by a blinded microbiologist. Growth was counted as the number of colony forming units. Baseline swabbing demonstrated 100% bacterial hub colonization in both connectors. The CAT syringe showed a significant reduction in CFU growth at 0 and 1?h compared with control syringes (p?<?0.05). At 4?h, the CAT syringe completely eliminated bacterial growth in both of the connector hubs. The CAT syringe can effectively disinfect both three-way and needleless connectors. 相似文献
875.
876.
Cutaneous histoplasmosis with prominent parasitization of epidermal keratinocytes: report of a case
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Hedieh H. Honarpisheh Jonathan L. Curry Kristen Richards Priyadharsini Nagarajan Phyu P. Aung Carlos A. Torres‐Cabala Doina Ivan Carol R. Drucker Richard Cartun Victor G. Prieto Michael T. Tetzlaff 《Journal of cutaneous pathology》2016,43(12):1155-1160
Disseminated histoplasmosis most commonly occurs in immunosuppressed individuals and involves the skin in approximately 6% of patients. Cutaneous histoplasmosis with an intraepithelial‐predominant distribution has not been described. A 47‐year‐old man was admitted to our institution with fever and vancomycin‐resistant enterococcal bacteremia. He had been diagnosed with T‐cell prolymphocytic leukemia 4 years earlier and had undergone matched‐unrelated‐donor stem cell transplant 2 years earlier; on admission, he had relapsed disease. His medical history was significant for disseminated histoplasmosis 6 months before admission, controlled with multiple antifungal regimens. During this final hospitalization, the patient developed multiple 2–5 mm erythematous papules, a hemorrhagic crust across the chest, shoulders, forearms, dorsal aspect of the fingers, abdomen and thighs. Skin biopsy revealed clusters of oval yeast forms mostly confined to the cytoplasm of keratinocytes and within the stratum corneum; scattered organisms were present in the underlying superficial dermis without any significant associated inflammatory infiltrate. Special stains and immunohistochemical studies confirmed these to be Histoplasma organisms. We highlight this previously unrecognized pattern of cutaneous histoplasmosis to ensure its prompt recognition and appropriate antifungal therapy. 相似文献
877.
Brian K. Heimbuch William H. Wallace Charles L. Balzli Michelle L. Laning Delbert A. Harnish 《Journal of occupational and environmental hygiene》2016,13(2):D11-D15
Nosocomial infections pose a significant and escalating threat to both patients and healthcare workers (HCWs). By their nature, hospitals induce antibiotic resistance in virulent and commensal strains, leading to increasingly severe hospital-acquired infections. This study measured environmental exposure experienced by domestic staff cleaning vacated patient rooms of a community hospital to bacteria in ambient bioaerosols. While they cleaned the room, participants wore an N95 filtering facepiece respirator (FFR), from which coupons were cut and bacteria were extracted, cultured and enumerated. Extrapolation to the full area of the respirator yielded measured exposures of 0.2–1.4 × 104 colony-forming units/hour, of which ~97% collected on the front layer of the N95, suggesting a possible role for minimal respiratory protection in nonpatient environments. Random resistance testing of 1.6% of the isolates showed that ~70% of both Gram-positive and Gram-negative organisms exhibited resistance to oxacillin and ~9% of the Gram-positives displayed resistance to vancomycin. These data provide an estimate for mask bioaerosol loading that can be used in risk modeling and to refine strategies for reuse of FFRs during critical shortages. 相似文献
878.
Raymond J. Roberge 《Journal of occupational and environmental hygiene》2016,13(4):235-242
Face shields are personal protective equipment devices that are used by many workers (e.g., medical, dental, veterinary) for protection of the facial area and associated mucous membranes (eyes, nose, mouth) from splashes, sprays, and spatter of body fluids. Face shields are generally not used alone, but in conjunction with other protective equipment and are therefore classified as adjunctive personal protective equipment. Although there are millions of potential users of face shields, guidelines for their use vary between governmental agencies and professional societies and little research is available regarding their efficacy. 相似文献
879.
《Orthopaedics and Trauma》2014,28(6):409-416
Musculoskeletal infections can involve bone, joints, muscles and soft tissues. The interpretation of imaging in musculoskeletal infections can be a diagnostic challenge and requires an integrated approach with clinical details and blood inflammatory markers. Imaging also plays a vital role in treatment planning and follow up. Conventional plain film radiography is still the cornerstone, which provides an overview of the bone and surrounding soft tissue pathology and should routinely be the first imaging procedure in patients with suspected musculoskeletal infection. The sensitivity of radiographs for the detecting of acute osteomyelitis is limited. Ultrasound can be used to assess soft tissue collections, joint effusions, and foreign body localization. It is invaluable in providing guidance for diagnostic joint aspiration, biopsy or therapeutic drainage of a soft tissue abscess/collection. CT scans are useful in providing bony detail and are particularly useful for evaluation of presence of sequestrum and in cases where MRI is contraindicated. MRI provides excellent anatomical details and evaluates both the soft tissues and bones and is the most sensitive and specific imaging modality for evaluating musculoskeletal infection. Radionuclide imaging can be helpful in cases of acute osteomyelitis and multifocal infection and has a high negative predictive value when normal. 相似文献
880.
目的:探讨胆管空肠Roux-en-y吻合术后逆行性胆管感染的相关临床因素。方法选择本院收治并实施胆管空肠Roux-en-y吻合术患者134例,分析糖尿病病史(有或无)、吻合口直径(≤2 cm或>2 cm)、吻合方式(侧侧吻合、端侧吻合)、术前黄疸持续时间(≤7 d或>7 d)、术前胆红素水平(≤171μmol/L或>171μmol/L)、术中抗菌药物(有或无)对术后逆行性胆管感染的影响。结果合并糖尿病患者发生逆行性胆管感染发生率高于无糖尿病患者,差异有统计学意义(P<0.05);吻合口直径≤2 cm患者发生逆行性胆管感染发生率高于吻合口直径>2 cm患者,差异有统计学意义(P<0.05);侧侧吻合患者的逆行性胆管感染发生率高于端侧吻合患者,差异有统计学意义(P<0.05)。结论胆管空肠Roux-en-y吻合术后逆行性胆管感染与患者是否合并糖尿病、吻合口大小及吻合方式有关,值得临床借鉴。 相似文献