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101.
目的 探讨以顺铂为主的化疗方案加放疗对局部晚期非小细胞肺癌的疗效。方法 86例局部晚期非小细胞肺癌患随机分为治疗组及对照组各43例,放疗方案以CAP、EP、MVP或MOP,每人至少化疗两个周期,化疗后10~14天放射治疗,放疗采用^60Co外照射。结果 治疗组有效率83.7%,中位生存期14.5个月,对照组有效率67.4%,中位生存期10个月,两组不良反应为骨髓抑制、胃肠道反应。结论 以顺铂为主的化疗方案加放疗治疗局部晚期非小细胞肺癌的疗效较高,可提高肿瘤的局部控制率和延长生存期。 相似文献
102.
目的:探讨高分子材料和种植体同期植入缺损区进行同步骨缺损修复和牙列缺损修复的可行性。方法:以4只杂种狗为研究对象,制备下颌骨长约2.5cm的缺损的动物模型(保留下颌骨下缘),将骨水泥(聚甲基丙烯酸酯)植入骨缺损,同时将牙种植体植入骨水泥中并调整长轴方向,立即关闭术创。至术后3个月摄X线片,然后处死动物,局部巨检以了解骨水泥同骨组织的结合情况,并制备骨组织切片进行苏木精一伊红染色和甲苯胺蓝染色,以了解植入材料周边骨的生长情况及其对植入材料的反应。结果:术后3个月X线检查见骨缺损区充满骨水泥,骨水泥周边的骨小梁清晰,未见骨吸收或炎症表现,形成良好的骨-骨水泥界面,种植体则依赖其表面的螺纹结构与骨水泥间紧密的机械性嵌合而牢固的成为一体,植入的骨水泥块与周边天然骨结合紧密,无松动现象。植入材料周边局部脱钙骨的苏木精-伊红染色和甲苯胺蓝染色见骨结构正常,同时骨-骨水泥界有新骨形成。结论:骨水泥作为颌骨修复替代材料同期植入种植体是可行的。 相似文献
103.
关于发展中医特色的卒中单元的思考 总被引:6,自引:0,他引:6
黄燕 《广州中医药大学学报》2002,19(3):243-244
阐述目前中风治疗的概况,介绍国外卒中单元(stroke unit,SU)在中风病人急救和康复治疗中的重要作用和SU的特色、优势及临床实践模式,分析了我国发挥中医优势、建立中西医结合SU的可能性及必要性。 相似文献
104.
Gazzaniga P. P. Ferroni P. Mina C. Pulcinelli F. M. Rizzo P. A. 《The Italian Journal of Neurological Sciences》1987,8(6):561-566
148 patients with various forms of cerebrovascular disease (CVD) were studied by means of a multiparametric analysis ofin vitro platelet aggregation, based on the following six parameters: ADP and epinephrine primary and secondary aggregation thresholds
and percent maximum aggregation induced by optimal concentrations of ADP and epinephrine. These patients were assigned to
four study groups, according to clinical diagnosis supported by CT scan, of transient ischemic attack and reversible neurological
deficit (TIA-RIND), or completed stroke, in the presence or absence respectively of antiplatelet medical treatment at the
time of the study. A statistically significant increase of thein vitro platelet aggregation was found in 44.4% of the untreated TIA-RIND patients and in 33.9% of the untreated stroke patients.
However this last group showed a higher percentage of very marked hyperaggregation. Differences between the two treated study
groups and controls were not signicant. No difference was found in collagen-and ristocetin-induced aggregation between the
patient groups and the controls.
Sommario 148 pazienti con varie forme di malattia cerebrovascolare, sono stati studiati con analisi multiparametriche dell'aggregazione piastrinica in vitro sulla base dei seguenti sei parametri: le soglie di aggregazione primaria e secondaria e l'aggregazione massima percentuale indotta da ADP ed Epinefrina. Questi pazienti sono stati suddivisi in 4 gruppi di studio in accordo con la diagnosi clinica confortata dai dati della TAC e cioè: TIA, RIND, o rammollimento in presenza o in assenza rispettivamente di un trattamento antiaggregante nel momento dello studio. è stato trovato un aumento statisticamente significativo dell'aggregazione in vitro delle piastrine nel 44.4% dei casi TIA, RIND non trattati e nel 33,9% dei casi di rammollimento non trattati. Quest'ultimo gruppo, però, ha dimostrato una più alta percentuale di iperaggregazione molto marcata. Le differenze tra i 2 gruppi di studio trattati con antiaggreganti e i controlli non erano significative. Inoltre nessuna differenza è stata riscontrata tra i gruppi e i controlli nell'aggregazione indotta da collageno e ristocetina.相似文献
105.
Inflammatory central nervous system disease in lupus-prone MRL/lpr mice: comparative histologic and immunohistochemical findings 总被引:7,自引:0,他引:7
Catherine M. Vogelweid Gayle C. Johnson Cynthia L. Besch-Williford Joe Basler Sara E. Walker 《Journal of neuroimmunology》1991,35(1-3):89-99
The brains of pathogen-free autoimmune MRL/lpr, NZBWF1 and NZB mice were examined for central nervous system (CNS) inflammation in premoribund 8-week-old animals and at ages when active systemic lupus erythematosus (SLE) was present. CNS inflammation was observed only in MRL/lpr mice. Immunohistochemical studies of brains from young MRL/lpr mice found that infiltrates were composed primarily of CD4+ cells. Older MRL/lpr mice (22 and 26 weeks of age) had CD4+ cells predominantly, but CD8+ and B220+ cells were also present. Perivascular leakage of IgG was a prominent and unexpected finding in the MRL/lpr model. Congenic MRL/+ mice with late-onset autoimmunity had no inflammatory cells in brain tissue, and there was no perivascular staining with IgG or albumin. Our findings suggest that MRL/lpr mice are a useful model for studies of lupus-associated CNS inflammatory disease, and perivascular leakage may be a primary mechanism for entry of IgG into the brain. 相似文献
106.
《Nutrition reviews》1987,45(10):246-248
Increasing dietary 18:2 n-6/18:3 n-3 causes similar relative changes in fatty acid profiles of phosphatidylethanolamine and phosphatidylcholine from rat neural and erythrocyte membranes. 相似文献
107.
多希紫杉醇联合顺铂治疗晚期非小细胞肺癌疗效观察 总被引:1,自引:0,他引:1
目的观察和评价多希紫杉醇联合顺铂(DP方案)治疗晚期非小细胞肺癌的疗效和毒性。方法将我科近几年收治的48例晚期非小细胞肺癌患者随机分为治疗组和对照组。治疗组采用多希紫杉醇联合顺铂(DP方案),对照组采用长春瑞滨联合顺铂(NP方案)。2周期化疗后进行疗效、毒性对比研究。结果治疗组和对照组近期有效率分别为45.5%和37.5%,疾病进展时间(TTP)分别为6.3和5.9个月,中位生存期分别为10.1和9.0个月,1年生存率分别为45.8%和39.4%,两组间比较差异均无显著性(P>0.05)。治疗组在恶心呕吐、骨髓抑制等毒性反应发生率方面低于对照组,差异有显著性(P<0.05)。结论多希紫杉醇联合顺铂治疗晚期非小细胞肺癌与NP方案相比较,疗效相似,但毒性反应低于NP组,患者更易耐受,可广泛应用于临床。 相似文献
108.
109.
Emilie Balasse Gregory Gatouillat Dominique Patigny Marie Christine Andry Claudie Madoulet 《Vaccine》2009
Malignant melanoma causes significant health problems. The identification of tumour-associated antigens has led to novel approaches to increase T cell mediated anti-tumour immune response. Melan-A/MART-1 has been use as target antigen for several T cell based immunotherapeutic treatments. More recently, the critical role of CD4+ T cells in inducing and maintaining anti-tumour immunity has been increasingly recognized. In order to optimize tumour immunotherapy, greater efforts have been concentrated on the identification of tumour antigens presented by MHC class II molecules to CD4+ T cells. In a publication, Tiwari et al. (2004) [1] have identified by a computational approach the 15-mer amino-acid sequence 101–115 (PPAYEKLSAEQSPPP) of the Melan-A/MART-1 as a good target for a vigorous and safe immunotherapy. Therefore, we have investigated the in vivo anti-tumour activity of this peptide in a murine melanoma model. For the prophylactic treatment, 20 μg or 50 μg peptide was subcutaneously injected in mice once a week during 3 weeks before tumour induction. Treatment with 50 μg peptide significantly affected tumour development. Thus, our preliminary data demonstrate potential in vivo prophylactic activity of the 101–115 peptide-based vaccine to control melanoma growth. 相似文献
110.