Sacral Magnetic Stimulation for Pain Relief from Pudendal Neuralgia and Sciatica

INTRODUCTION: Magnetic stimulation of the sacral nerve roots is used for neurologic examination. However, no one has reported therapeutic efficacy of pain relief from pudendal neuralgia with sacral magnetic stimulation. METHODS: Five patients with pudendal neuralgia or sciatica received 30 to 50 pulsed magnetic stimuli of the sacral nerve roots. The median age of the patients was 59 (range, 28–69) years; there were 3 females. RESULTS: Sacral magnetic stimulation immediately eliminated the pain. The pain relief lasted between 30 minutes and 56 days (median, 24 hours). Adverse effects were not observed. CONCLUSIONS: This pilot study indicates that magnetic stimulation of the sacral nerve roots may be a promising therapeutic modality for pain relief from pudendal neuralgia and sciatica. Further studies should be performed to determine the appropriate intensity and frequency, as well as the utility of a second course, of magnetic stimulation treatment.     

特发性非特异性间质性肺炎与普通型间质性炎疾病特征和预后的比较分析

目的 与普通型间质性肺炎(usual interstitial pneumonia,UIP)进行比较分析,探讨特发性非特异性间质性肺炎(idiopathic nonspecific interstitial pneumonia,INSIP)的疾病特征和预后以及与UIP的鉴别诊断.方法 发对经电视胸腔镜或小切口开胸肺活检诊断的21例INSIP患者和18例UIP患者的临床-影像-病理学资料及疗效、预后进行比较分析.结果 INSIP多见于40～50女性,临床表现无特异性,主要表现为活动后气促、咳嗽、咯痰、双下肺可有或无吸气相爆裂音;高分辨率CT(HRCT)表现为双肺弥漫分布的磨玻璃样淡斑片状和不规则网织状阴影,部分可有蜂窝肺.INSIP的病理特征为病变进展相对一致,按病理表现可分为细胞型、纤维化型和混合型.与UIP相比,纤维母细胞灶、肌硬化、镜下蜂窝肺和肺泡结构改建的检出率在INSIP和UIP分别是19.05%和100%(P<0.001),19.05%和88.89%(P<0.05),23.81%和94.44%(P<0.01),33.33%和100%(P<0.01).两者对糖皮质激素的反应率分别为76.19%和38.89%(P<0.01),各型INSIP的预后均明显好于UIP.结论 经 INSIP的一般临床表现差异不明显,HRCT对疑难病例的鉴别诊断有帮助,明确诊断依赖肺活检病理诊断;纤维母细胞灶、伴胶原沉积的瘢痕化和蜂窝变组成不同时相的病变共同构成诊断UIP的形态特征,也是与INSIP的鉴别要点.     

体表QRS电轴与特发性室性心律失常射频导管消融关系的探讨

目的探讨体表QRS电轴与特发性室性心律失常射频导管消融的关系。方法对65例特发性室性心律失常患者采用激动顺序标测和起搏标测法确定室性搏动起源部位并测量其QRS电轴,分析与消融成功的关系。结果65例中室性心动过速24例(左心室源性18例、右心室源性6例),室性期前收缩41例(右心室流出道起源)。其中18例左心室源性室性心动过速,电轴左偏13例,12例(平均-80°)均一次消融成功,另1例出现两种形态室性心动过速,电轴分别为-55°、-30°,为消融失败;电轴右偏5例(平均227°),只有2例(265°、261°)消融成功。电轴左偏者消融成功率(92.3%)与电轴右偏者(40.0%)比较,差异有显著性意义(P<0.05)。6例右心室源性室性心动过速电轴正常(平均84°),且均消融成功。而41例右心室室性期前收缩中,电轴正常37例(64°～90°)消融成功。4例电轴轻度右偏者2例(97°)消融成功,2例(99°、100°)消融失败。电轴正常消融成功率(100%)与右偏者(50.0%)比较,差异有显著性意义(P<0.05)。结论体表室性QRS电轴对术前判断室性心律失常的起源部位、指导标测和缩短标测时间及推断射频导管消融成功的可能性均具有一定的价值。     

Ineffectiveness of interferon-γ in the treatment of idiopathic myelofibrosis: a pilot study

 It has been proposed that interferon-γ (IFN) inhibits collagen synthesis in myeloproliferative disorders through an inhibitory effect on PDGF and TGF-β. We therefore evaluated the role of IFN-γ on bone marrow fibrosis in idiopathic myelofibrosis (IMF). After a 3-month observation period, nine patients (five female, four male), median age 64 years (range 43–72 years), received 3×3 mU IFN-γ/week over 6 months and were monitored after withdrawal of IFN-γ for further 3 months. Three out of nine patients have completed the study according to the protocol. Six patients had to be withdrawn from IFN-γ due to the following reasons: bacterial infection (three patients), splenic infarction or deterioration of splenomegaly (one patient, each) and refusal to continue IFN-γ (one patient). Results from seven patients treated for at least 8 weeks were considered measurable. Leukopenia, initially present in one of the evaluated patients, deteriorated during IFN-γ treatment. This patient died during the observation period shortly after withdrawal of the therapy as a result of septicemia. Transfusion-dependent anemia, initially observed in two of the evaluated patients, deteriorated during the IFN-γ treatment. Bone marrow fibrosis increased in three patients, whereas it remained unchanged in another and improved in a further patient. Splenomegaly improved in two patients but deteriorated markedly in one. Taking these observations together, four patients had disease progression during IFN-γ treatment, two had stable disease and one could be qualified as a partial responder. According to these data IFN-γ cannot be considered as a treatment option for patients with IMF. Received: 7 February 2000 / Accepted: 14 July 2000     

Clinical,radiological, and pathological features of anti-asparaginyl tRNA synthetase antibody-related interstitial lung disease

BackgroundMyositis and interstitial lung disease (ILD) frequently occur in patients with anti-aminoacyl-tRNA synthetase (ARS) antibodies. Nearly half of ARS-ILD patients have the acute or subacute form of the disease, and one-third of these patients show a deterioration in pulmonary function over the long-term course because of frequent recurrences and refractoriness to therapy. Several reports recently described different characteristics depending on the individual anti-ARS antibodies, and the anti-asparaginyl tRNA synthetase (KS) antibody was strongly linked to ILD rather than to myositis. We therefore hypothesized that KS-ILD may have clinical characteristics that differ from those of other ARS-ILDs. The aim of this study was to clarify the clinical, radiological, and pathological features of KS antibody-positive ILD.MethodsWe retrospectively analyzed 19 consecutive patients with KS-ILD who underwent initial clinical measurements and high-resolution computed tomography and pathological assessments. We also analyzed disease behavior based on pulmonary function test results during the follow-up period.ResultsOur KS-ILD cohort included patients with dermatomyositis (10.5%), primary Sjögren syndrome (5.3%), and idiopathic ILD (84.2%). Most patients presented with chronic onset (89.5%) and a nonspecific pattern of interstitial pneumonia at each radiological and pathological assessment (89.4% and 85.7%, respectively). The pulmonary function test results showed that the mean changes from the initial %forced vital capacity and %diffusing capacity of the lung for carbon monoxide at 3 years were 3.7% ± 2.9% and 9.35% ± 3.0%, respectively.ConclusionsMost KS-ILD patients showed a tendency for chronic disease onset and long-term stabilization of pulmonary function.     

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??Objective    On the basis of this experiment in simulated clinical vascular compression of the trigeminal root??use the agar compression of trigeminal nerve root by 3D positioning to establish a new animal model of trigeminal neuralgia and relevant research. Methods    Adult male Sprague-Dawley rats were randomly divided into 2 groups??Experimental group??the rat head brain locator targeted to the trigeminal nerve root and 5% agar solution??10μL??was injected into the trigeminal nerve root by using miro syringe??Control group rats positioning micro syringe to the trigeminal nerve root injection of saline solution. Preoperative 1 d and postoperative 1??2??3??5??7??10??14??21??28??35??42 d respectively with behavioral observation of animals??Von Frey fiber mechanical stimulation reaction threshold determination in rats??use the ANOVA and T test for data statistics analysis. At the same time take the trigeminal nerve with HE and silver staining and trigeminal ganglion in the astrocytes GFAP immunefluorescence detection. Results    Experimental rat lateral mechanical stimulation reaction threshold operation gradually reduce and stabilize last about 30 days after surgery??P??0.05??. HE and argentophilic staining showed swelling of the nerve fibers??demyelinating changes??the surgical operation side trigeminal ganglion of rats in astrocytes increased GFAP expression. Conclusion    Agar compression in the rat trigeminal nerve root can establish a reliable and effective animal model for the future further research of etiology and treatment of TN provide a reliable and effective animal model.     

特发性血小板减少性紫癜患者B淋巴细胞凋亡研究

目的探讨B淋巴细胞在特发性血小板减少性紫癜(ITP)发病机制中的作用。方法用流式细胞术检测ITP患者外周血B淋巴细胞表面Fas蛋白、FasL蛋白以及胞浆内抗凋亡蛋白bcl2的表达水平。结果ITP患者外周血中B淋巴细胞表面Fas和FasL蛋白表达与对照组相比无统计学意义,B淋巴细胞胞浆内bcl2的表达水平高于正常人(P<0.05)。结论B淋巴细胞凋亡受抑可能参与ITP自身免疫的发病机制。     

Serum cytokine changes induced by direct hemoperfusion with polymyxin B-immobilized fiber in patients with acute respiratory failure

BackgroundPolymyxin B-immobilized Fiber therapy (PMX-DHP) may improve the prognosis of patients with rapidly progressive interstitial lung diseases (ILDs). However, the mechanisms by which PMX-DHP ameliorates oxygenation are unclear. The present study aimed to clarify the changes in serum cytokine concentrations during PMX-DHP with steroid pulse therapy.MethodsPatients with acute respiratory failure (ARF) and rapidly progressive ILDs, acute exacerbation of idiopathic pulmonary fibrosis (IPF), or acute respiratory distress syndrome (ARDS), and treated with PMX-DHP were assessed, including patients with IPF. The serum concentrations of 38 cytokines were compared between the ARF and IPF groups before treatment. In the ARF group, cytokine levels were compared before, immediately after PMX-DHP, and the day after termination of steroid pulse therapy.ResultsFourteen ARF and eight IPF patients were enrolled. A comparison of the cytokine levels before treatment initiation revealed that EGF, GRO, IL-10, MDC, IL-12p70, IL-15, sCD40L, IL-7, IP-10, MCP-1, and MIP-1β were significantly different between the two groups. In the ARF group treated with PMX-DHP, the concentrations of MDC, IP-10, and TNF-α continuously decreased during treatment (P < 0.01). Further, the cytokine levels of GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 decreased after the entire treatment period, with no change observed during the steroid-only period (P < 0.01, except GRO and MCP-1). Although PMX-DHP significantly reduced eotaxin and GM-CSF serum levels (P < 0.01 and P < 0.05), these levels did not change after treatment.ConclusionsPMX-DHP combined with steroid pulse therapy might reduce GRO, IL-10, IL-1Ra, IL-5, IL-6, and MCP-1 levels in ARF, contributing to better oxygenation in the disorder.     

肥大细胞对特发性眼眶炎性假瘤纤维化的作用研究

目的：探讨肥大细胞在特发性眼眶炎性假瘤纤维化中的作用。方法：将分离纯化的大鼠骨髓肥大细胞和同源大鼠眼眶成纤维细胞,分别进行单独和共育培养。观察肥大细胞和成纤维细胞共育对成纤维细胞在形态和数量上的影响。结果：肥大细胞和成纤维细胞共育能够显著增强成纤维细胞的增殖活性,共育组中单位面积内的成纤维细胞数较对照组显著增加,差异具有统计学意义P﹤0.01）。结论：肥大细胞对眼眶成纤维细胞的增殖具有显著的促进作用,提示其在特发性眼眶炎性假瘤纤维化过程中发挥着重要作用。