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41.
冯娟 《中国医师进修杂志》2007,30(7):12-13,16
目的探讨新生儿行为神经测定(NBNA)联合儿心量表在预测胆红素神经毒性中的价值。方法将2006年1~12月收治的足月无缺氧、窒息病史的高胆红素血症患儿76例,根据脑干听觉诱发电位(ABR)表现分成A、B、C三组,比较三组患儿治疗前、治疗后7、14d的NBNA总分及随访至1岁行儿心量表检测的发育商(DQ),分析NBNA及儿心量表与ABR的相关性。结果与A、B组比较,C组NBNA及儿心量表明显异常,可见NBNA及儿心量表与ABR的异常密切相关。结论NBNA联合儿心量表是预测胆红素神经毒性的良好指标。 相似文献
42.
护理干预防治早产儿高胆红素血症的效果分析 总被引:1,自引:1,他引:1
目的探讨综合护理干预对早产儿高胆红素血症的防治效果。方法将160例早产儿随机分为两组各80例。对照组接受常规治疗和护理,观察组在此基础上给予包括灌肠、抚触、腹部按摩和营养支持在内的综合护理干预。采用钒酸盐法监测两组患儿血清胆红素值,记录黄疸的出现时间、持续时间和消退时间。结果观察组患儿出生后d4和d6的血胆红素值明显低于对照组,差异有统计学意义,均P〈0.01(t=16.142,20.329),而且黄疸出现时间、持续时间和消退时间明显短于对照组,差异有统计学意义,均P〈0.01(t=10.550,17.151,12.981)。观察组高胆红素血症发生率明显低于对照组,差异有统计学意义(X^2=18.829,P〈0.01)。结论综合护理干预可减少早产儿高胆红素血症的发生,从而提高患儿的生存质量。 相似文献
43.
目的:探讨葡萄糖6磷酸脱氢酶(G6PD)缺乏与新生儿高胆红素血症发生率及发病时间的关系。方法:对近年来本院产科分娩的新生儿脐血进行G6PD定量测定,对G6PD活性缺乏的患儿,按性别和缺乏程度分组调查其高胆红素血症发生率和发病时间。结果:①G6PD缺乏的患儿高胆红素血症发生率极显著高于对照组的新生儿。②在G6PD缺乏的患儿中,男性G6PD缺乏程度极显著低于女性(P<0.01);男性高胆红素血症发生率极显著高于女性(P<0.01);G6PD缺乏程度不同的患儿高胆红素血症发生率有显著差别(P<0.05)。③G6PD缺乏的患儿高胆红素血症的发病时间主要在出生后的1周内。结论:G6PD缺乏是新生儿发生高胆红素血症的病因之一。在G6PD缺乏的患儿中,高胆红素血症发生率具有男性多于女性、G6PD缺乏程度越重发病率越高、发病的高峰时间在出生后的2~4天。 相似文献
44.
45.
目的比较两种蓝光疗法治疗新生儿高胆红素血症对甲状腺功能的影响.方法将患儿随机分为Bilibed婴儿蓝光床治疗(A组)18例、传统温箱加双面蓝光照射治疗(B组)18例.观察两组治疗前后高胆红素血症的含量变化并比较对甲状腺功能的影响.结果两组光疗前后血清胆红素较治疗前下降(P<0.05),A组治疗后血清胆红素下降较B组明显(P<0.05);A组副作用小于B组(P<0.05~0.01);两组光疗前后甲状腺功能指标变化无统计学意义(P>0.05).结论Bilibed婴儿蓝光床副作用小,疗效优于传统光疗法,对甲状腺功能无影响. 相似文献
46.
Hemodiafiltration has assumed an important role in the supportive therapy of critically ill patients. The viability of the
filter used for hemodiafiltration can be monitored by estimating the sieving coefficient of small molecules such as creatinine
and/or urea. We report on three patients with severe hyperbilirubinemia whose creatinine sieving coefficient was spuriously
elevated as a result of discordance in the accuracy of creatinine measurement in plasma and ultrafiltrate respectively. This
discordance was a consequence of lack of bilirubin clearance during hemodiafiltration. As a result, while the plasma creatinine
determination by the kinetic Jaffe method was negatively influenced by the hyperbilirubinemia, the ultrafiltrate creatinine
was not. This report is the first to document the lack of bilirubin clearance during hemodiafiltration and its impact on the
calculation of sieving coefficient based on creatinine. The use of urea as the solute for determining the sieving coefficient
allows for an accurate estimate and provides a valid means of monitoring this parameter in the setting of hyperbilirubinemia.
Received: 18 April 2000 / Revised: 16 June 2000 / Accepted: 20 June 2000 相似文献
47.
目的:探讨6种母子ABO血型不合的新生儿脐血血型血清学检验结果及临床型HDN发生率。方法:按检验操作规程对1199例母子ABO血型不合的新生儿脐血做血型血清学检验,在出生7天内分组调查其高胆红素血症发生率。结果:①母/子血型O/A(B)组合的新生儿抗体释放试验、DAT、IAT阳性率、临床型HDN发生率均极显著高于母/子血型A/B、A/AB、B/A、B/AB组合的新生儿(P<0.01)。②新生儿脐血血型血清学检验结果与临床型HDN发生率呈显著正相关性(P<0.01)。③患儿血液中存在的IgG抗-A+B对临床型HDN发生率无显著影响(P>0.01)。结论:ABO血型系统发生的临床型HDN以母/子血型O/A(B)组合的患儿为主(89.19%),母/子血型A/B、A/AB、B/A、B/AB组合的患儿较少(10.81%)。抗体释放试验阳性患儿血液中存在的游离抗体对判断患儿疾病的发展趋势有一定的意义。 相似文献
48.
49.
Tatsuharu?Yamada Toshiyuki?Arai Masato?Nagino Koji?Oda Junichi?Shoda Hiroshi?Suzuki Yuichi?Sugiyama Yuji?NimuraEmail author 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2005,390(5):421-429
Background and aims Hyperbilirubinemia is a critical complication following hepatectomy for biliary cancer. Hepatic multidrug resistance protein 2 (MRP2), a bilirubin transporter, is shown to be down-regulated by acute biliary obstruction in rats. However, little is known about the effect of chronic obstruction by malignancy on the MRP2 expression in patients or the association of MRP2 expression with posthepatectomy hyperbilirubinemia.Materials and Methods The MRP2 expression before hepatectomy was determined by immunostaining and Western blotting in patients with biliary cancer. To directly determine the effect of chronic bile duct obstruction on the MRP2 expression, the expression levels were compared between the cholestatic and noncholestatic lobes in each of seven patients. In another 39 patients, the correlation of the MRP2 expression of the anticipated remnant liver with the posthepatectomy severe hyperbilirubinemia, defined as a serum total bilirubin concentration200 mol/l, was evaluated.Results The MRP2 staining in the cholestatic lobes was weak and not restricted to the canalicular membrane, unlike the noncholestatic lobes. The expression levels in the cholestatic lobes were 45% of those in the noncholestatic lobes. Postoperative maximum bilirubin levels were significantly correlated with MRP2 expression of the anticipated remnant liver. The MRP2 expression had been already impaired before hepatectomy in all patients who eventually developed severe hyperbilirubinemia.Conclusions Decreased MRP2 expression, caused by biliary obstruction due to cancer, is a possible risk factor for posthepatectomy severe hyperbilirubinemia. 相似文献
50.
Karolyi L Pohlandt F Muche R Franz AR Mihatsch WA 《Acta paediatrica (Oslo, Norway : 1992)》2004,93(7):941-944
AIM: To evaluate whether transcutaneous bilirubinometry (TcB) would be a reliable and efficient screening technique for hyperbilirubinaemia in very low birthweight (VLBW, < or =1500 g) infants in an intensive care unit setting. METHODS: TcB measurements (Minolta Airshield Jaundice Meter JM-102, Osaka, Japan) were obtained immediately before or within 10 min following routine blood sampling for plasma bilirubin concentration measurements in 124 VLBW infants not receiving phototherapy. The relationship between the two techniques was analysed by linear regression analysis. A plasma bilirubin > or =150 micromol/l was defined as hyperbilirubinaemia. The sensitivity and specificity of possible TcB cut-off readings to detect hyperbilirubinaemia was evaluated. RESULTS: There was a significant correlation between the measurements of both techniques (p < 0.0001, r = 0.68). In the present study, a TcB cut-off reading of 14 would have reduced the need for plasma bilirubin measurements by 26% without missing true hyperbilirubinaemia. CONCLUSION: The data suggest that TcB will improve VLBW infant care in an intensive care unit setting by reducing the need for invasive bilirubin concentration measurements. 相似文献