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Kundan Mittal Jaya Shankar Kaushik Gurpreet Kaur Mohd Aamir Suvasini Sharma 《Annals of Indian Academy of Neurology》2014,17(2):207-208
The Sturge Weber syndrome is characterized by developmental delay, seizures in infancy, unilateral cutaneous lesions with ipsilateral leptomeningeal enhancement. We report an unusual presentation of Sturge Weber syndrome with bilateral port wine nevus on the trunk and face along with bilateral cortical involvement in a developmentally normal child with progressive megalencephaly. 相似文献
43.
Rubén Antonio Vázquez‐Roque Kiren Ubhi Eliezer Masliah Gonzalo Flores 《Synapse (New York, N.Y.)》2014,68(1):31-38
The neonatal ventral hippocampal lesion (nVHL) has emerged as a model of schizophrenia‐related behavior in the rat. Our previous report demonstrated that cerebrolysin (Cbl), a neuropeptide preparation which mimics the action of endogenous neurotrophic factors on brain protection and repair, promoted recovery of dendritic and neuronal damage of the prefrontal cortex and nucleus accumbens and behavioral improvements in postpubertal nVHL rats. We recently demonstrated that nVHL animals exhibit dendritic atrophy and spine loss in the basolateral amygdala (BLA). This study aimed to determine whether Cbl treatment was capable of reducing BLA neuronal alterations observed in nVHL rats. The morphological evaluation included examination of dendrites using the Golgi‐Cox procedure and stereology to quantify the total cell number in BLA. Golgi‐Cox staining revealed that nVHL induced dendritic retraction and spine loss in BLA pyramidal neurons. Stereological analysis demonstrated nVHL also produced a reduction in cells in BLA. Interestingly, repeated Cbl treatment ameliorated dendritic pathology and neuronal loss in the BLA of the nVHL rats. Our data show that Cbl may foster recovery of BLA damage in postpubertal nVHL rats and suggests that the use of neurotrophic agents for the management of some schizophrenia‐related symptoms may present an alternative therapeutic pathway in these disorders. Synapse, 68:31–38, 2014 . © 2013 Wiley Periodicals, Inc. 相似文献
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This study aimed to elucidate the macroscopic and microscopic distributions of the dorsal nerve of penis (DNP) that provides the greatest sensitivity over the glans penis. The glandes of 23 penises of formalin-embalmed cadavers were investigated to confirm the macroscopic and microscopic distributions of the DNP within the glans penis by whole-mount Sihler's staining and histological sectioning. Superficial regions of the mid-glans were reconstructed in three dimensions to define the microstructure of terminal branches of the DNP that project towards the skin surface. A mean of 6.7 bundles of the DNP consisting of several nerve fibres converged linearly towards the distal end of the penis, rather than diverging laterally as they travelled. Lateral branches of the DNP extended linearly to the distal end with ramifications, while dorsomedial branches of the DNP gave off nerve fibres to the dorsum of the mid-glans and the corona. The intrastromal ramifications of the DNP were more developed in the distal half of the glans penis than the proximal glans containing the corpus cavernosum. These ramifications gave rise to radial nerve fibres that project towards the skin surface to form a plexiform network of terminal branches in the dermis. Linear projections of the main branches of the DNP throughout the glans and fine networks of terminal branches in the dermis were distinctly visualized in the human penis. 相似文献
46.
《Diagnostic Histopathology》2014,20(3):102-108
It is now widely accepted that fatty liver disease is one of the commonest causes of cirrhosis and liver cell cancer (even in the absence of cirrhosis), in its own right as well as being an important cofactor for the progression of other diseases e.g. viral hepatitis. While much work has been done on developing non-invasive techniques for assessing liver disease, the liver biopsy remains the benchmark against which these tests have to be validated as well as providing information that cannot be obtained in any other way. This review describes the histological features that alcoholic and non-alcoholic liver disease have in common (e.g. fatty change, ballooning and Mallory–Denk bodies) as well as identifying those that are more characteristic of each of them (e.g. nuclear vacuolation in non-alcoholic fatty liver disease and a florid fatty liver hepatitis in alcoholic fatty liver disease). Recent developments in the assessment of the degree of fatty change are described. 相似文献
47.
An outbreak of hepatitis B virus (HBV) infection in a children's oncology unit was identified in which 61 children were shown to have been infected, 59 of them asyptomatically. In order to establish whether intra-unit cross infection had occurred, we used the single strand conformational polymorphism (SSCP) technique to analyse viral isolates from 57 of the infected children and 40 unrelated controls. HBV-specific primers were designed to amplify a 189 bp fragment of DNA encompassing part of the hypervariable pre-S1 region of the HBV genome. Denatured PCR products were compared after electrophoresis through polyacrylamide gels and staining with silver. By SSCP analysis, the unrelated infections each yielded a unique electrophoretic banding pattern, indicative of a variety of distinct virus strains. In contrast, most of the oncology patients had been infected with one of only five different strains. Three major groups comprising 19, 16, and 9 patients, respectively, and two minor groups of 5 and 3 patients were identified. Results indicate the occurrence of multiple episodes of cross infection, and demonstrate the sensitivity and value of SSCP as a technique to establish common sources of infection. © 1996 Wiley-Liss, Inc. 相似文献
48.
牙着色即牙的外部颜色改变。国内外学者在体外建立牙的着色实验模型,探讨牙着色的影响因素,并对牙着色的清除方法作了研究。本文对相关研究的最新进展作一综述。 相似文献
49.
Quantitative analysis of the spinal cord motoneuron under chronic compression: an experimental observation in the mouse 总被引:5,自引:0,他引:5
Hisatoshi Baba Yasuhisa Maezawa Shinichi Imura Norio Kawahara Kenji Nakahashi Katsuro Tomita 《Journal of neurology》1996,243(2):109-116
We investigated quantitative changes in spinal cord motoneurons following chronic compression using a mouse model of cervical
cord compression. Twenty-five tiptoe-walking Yoshimura (twy) mice with calcified mass lesions compressing the spinal cord
posterolaterally at the C1–C2 vertebral levels were compared with five Institute of Cancer Research (ICR) mice that served
as controls. Spinal cord motoneurons in the anterior grey horn between the C1 and C3 spinal cord segments were Nissl-stained
and counted topographically and then analysed in relation to the extent of spinal cord compression. The number of motoneurons
in C1–C3 spinal cord segments decreased significantly with a linear correlation with the transverse area of the spinal cord
when the cord was compressed to 50–70% of control values. A significant reduction in the number of motoneurons occurred at
the C2–C3 spinal cord segment compressed at the C1–C2 vertebral level. In contrast, at the level rostral to the C1 vertebra,
the number of motoneurons increased significantly in proportion to the magnitude of compression. The current study demonstrates
that a number of neurons, morphologically consistent with anterior horn cells, were observed at a rostral site absolutely
free of external compression where no such cells normally exist. 相似文献
50.