Genre et accidents vasculaires cérébraux à Brazzaville

BackgroundThe relationship between gender and cerebrovascular disease is controversial. The aim of our study was to evaluate the relationship between gender and vascular risk factors, biological variables and the severity of the neurological deficit in stroke.MethodsThis cross-sectional study, conducted from March to August 2011 in the department of neurology of the university hospital of Brazzaville which included all patients hospitalized for confirmed stroke. The study variables were: age, sex, vascular risk factors, NIHSS scores and Glasgow, blood pressure, and the biological exams and complications. Statistical analysis was performed on SPSS12.ResultsEighty patients were included. The mean age was 62.7 ± 11.2 years, with 58.8% of men. Alcohol intake and smoking were more frequent in men than women respectively P = 0.005 and P = 0.032. Psychosocial stress was more often declared by women than men (P = 0.042). However there was no significant difference in biological variables, the severity of stroke and the occurrence of complicationsConclusionOur study suggests that in the Congolese context, gender does not influence significantly most parameters during stroke, but men consume more alcohol and women are exposed to psychosocial stress.     

What is the UK Gender Duty and why is it linked to men's health?

Emerging from contemporary UK equality policy, the Gender Duty is not ostensibly about health, although men's health groups are keen to use it to bring about improvements in the health of men. Nevertheless, the status of men's health as an inequality is contentious and any links to equality policy should not be left unquestioned. In this article, I try to develop a critical but supportive perspective regarding the potential of equality legislation for improving men's health by describing the Gender Duty and exploring the links between equality and human rights and men's health.     

Abuse and neglect in adolescents of Jammu,India: The role of gender,family structure,and parental education

The present study aimed to assess the factor structure of the childhood trauma questionnaire (CTQ; Bernstein & Fink, 1998), and use it to describe the prevalence of abuse and neglect in Indian adolescents, and its associations with gender, family structure (nuclear vs. joint), and level of parental education. Participants were 702 adolescents from Jammu in the age range of 13–17 years (41.5% female). We found acceptance for a four-factor intercorrelated model for the CTQ with emotional abuse, physical abuse, sexual abuse, and neglect (5 emotional neglect and 2 physical neglect items) factors following a confirmatory factor analysis (CFA). Forty-one to sixty-one percent of adolescents reported maltreatment which is higher in comparison with CTQ based studies from the West. Analysis of CFA with covariates (MIMIC model) indicated that males, and adolescents of less educated mothers’ and from joint families reported higher abuse and neglect, and sexual abuse, respectively, while fathers’ education level was not associated with abuse or neglect. Implications of these findings are highlighted.     

Allelic variants in the zinc transporter-3 gene,SLC30A3, a candidate gene identified from gene expression studies,show gender-specific association with schizophrenia

Previous microarray analysis of gene expression in frontal cortex showed differential expression of genes associated with synaptic function in schizophrenia compared to matched-controls in two independent cohorts. One of these genes validated in both cohorts, SLC30A3, which encodes the Zinc Transporter 3 (ZNT3), is localised to synaptic vesicles in glutamate synapses and known to be involved in cognitive function. In view of the robust depletion of SLC30A3 mRNA in two independent studies and the importance of this gene in cognitive function, we investigated whether single nucleotide polymorphism (SNP) associations with schizophrenia could be detected in a UK case controlled schizophrenia cohort. Four SNPs were selected across this gene and genotyped in a cohort of cases and controls from East UK. We found significant associations with schizophrenia at the allelic (ORs: 1.51 to 1.57), genotype (ORs: 1.46 to 1.53) and haplotype level (P = 2.15 × 10⁻⁴). These associations proved to be gender-specific with significant effects of allele (ORs: 1.74 to 2.11), genotype (ORs: 1.78 to 2.14) and haplotype (P = 3.51 × 10⁻⁵) observed in female schizophrenia cases but not males, when split by gender. In conclusion, SNPs in SLC30A3 showed a gender-specific association with schizophrenia in this East UK cohort, which merits further investigation in other population samples.     

大学生性别角色与职业性别刻板印象的关系

目的探讨大学生性别角色与职业性别刻板印象的关系。方法采用贝姆性别角色量表与职业性别刻板印象问卷对某高校大学生进行了测量。结果在大学生4种性别角色类型中,双性化占33.1%、未分化占29.0%、女性化占20.4%、男性化占17.5%。大学生的男性职业性别刻板印象和女性职业性别刻板印象在性别上均存在显著差异(F=13.647,26.957;P<0.05),在不同性别角色类型上差异均不显著。结论大学生的职业性别刻板印象处于中等水平,应该弱化其职业性别刻板印象,以促使其更好地就业。     

Landscape assessment for gender neutral human papillomavirus vaccination recommendations including head and neck cancer burden data

IntroductionHead and neck cancers (HNC) accounted for over 450,000 deaths and 900,000 cases in 2018 worldwide. Of those, 38,000 cases were attributable to human papillomavirus (HPV). HNC is two to four times more prevalent in men than in women. The incidence of oropharyngeal cancers (OPC) and oral cavity cancers caused by HPV has increased in recent decades. Given the substantial burden of HPV-related HNC in males, this study aimed to assess whether and how national agencies included HPV-related HNC when evaluating HPV genderneutral vaccination (GNV) programs.MethodsA systematic literature review was conducted in MEDLINE® and EMBASE®, and on the websites of selected national agencies.ResultsSearches identified a potential 205 records; seventeen were eligible for the review. Seventy percent of assessments were published by European countries and most were recent (2014–2019). Eleven (65%) reports considered OPC when discussing HNC, and a few included other anatomic sites. All reports that considered incidence data were in consensus that incidence of OPC was higher in men and showed that the mortality rates for HPV-related HNC were also higher in men. When looking at the economic impact, the incremental cost-effectiveness ratios in the assessments varied widely, as the inputs into the analyses were heterogeneous. However, several reports concluded GNV programs were likely to be cost-effective versus not vaccinating males.ConclusionThe burden of HPV-related HNC in the general male population has been recognized by several Heatlth Technology Assessment (HTA) agencies and National Immunization Technical Advisory Groups (NITAGs) when evaluating HPV GNV programs. The assessments identified on GNV programs strongly indicate a cost-effective clinical benefit. Nevertheless, the epidemiological burden of HNC may have been underestimated in some countries due to limited data. Further research is crucial to obtain more robust data that will help address the information gap in epidemiological and economic burden of HPV-associated HNC in men.     

Long-term health issues related to disorders or differences in sex development/intersex

DSD (Disorders or Differences in Sex Development) and Intersex are terms used to describe a diverse group of congenital conditions where the development of the reproductive system is different from what is usually expected. These conditions usually present at birth or adolescence and the health implications are wide ranging and often life-long. Given the complexity of many of the conditions, health care input when required should be provided by a multidisciplinary team who have appropriate expertise. Holistic care should include the consideration of the risk of cancer, prevention of osteoporosis, advice on hormones, sexual health and fertility options, and ongoing support in order to optimise quality of life and wellbeing. There is little evidence on the health of this group of individuals beyond middle age. Research in this field is essential to guide clinicians in providing high-quality care but also to allow affected individuals to make informed decisions about their own health care. This review will focus on the gynaecological aspects of multidisciplinary management.