血清铁蛋白、同型半胱氨酸与急性脑梗死的关系

目的探讨血清铁蛋白（SF）、同型半胱氨酸（Hcy）含量与急性脑梗死（CI）患者的关系。方法对60例急性脑梗死患者、50例健康对照者以放免法测定血清铁蛋白（SF），采用化学发光法检测血清同型半胱氨酸（Hcy），同时检测Hcy的代谢因子维生素B，：（Vit．B12）、叶酸（Fa）含量。结果和健康对照组比较CI患者组血清SF、Hey明显增高，P〈0．01，Hcy的代谢因子叶酸和Vit．B12亦明显降低，P〈0．01。结论血清铁蛋白、同型半胱氨酸与急性脑梗死密切相关，而同型半胱氨酸主要与叶酸和Vit．B12营养性缺乏有关，SF、Hcy、Vit．B12、Fa参与了CI的病理、生理过程。对急性脑梗死患者应注意监测Hcy并予相应治疗，以利于患者的康复。     

铁超负荷与II型糖尿病关系的研究

目的探讨铁超负荷与II型糖尿病(Diabetes Mellitus,DM)之间的关系。方法采用放射免疫方法测定血清中的铁蛋白(Serum Ferritin,SF)和胰岛素(INS)含量,用全自动生化分析仪测定血清铁(SerumIron,SI)和血糖的浓度。结果与对照组相比,II型糖尿病患者SF水平和胰岛素抵抗指数(Homeostasis Model Assessment-Insulin Resistance,HOMA-IR)显著升高(P<0.01)。结论II型糖尿病存在铁超负荷,造成IR。铁超负荷可能是II型糖尿病的一种重要风险因子。     

癌胚抗原及铁蛋白检测对胸腔积液鉴别诊断的意义

目的探讨癌胚抗原（CEA）、铁蛋白（FT）检测在良、恶性胸腔积液诊断的临床意义。方法对28例结核性胸腔积液患者及36例恶性胸腔积液患者的血清及胸水采用放射免疫直接测定法测定其CEA及FT水平。结果恶性胸水组血清CEA、FT水平显著高于结核组（P〈0．01）。恶性胸水胸液CEA、FT水平显著高于结核组（P〈0．001）。结论联合进行血清、胸水CET、FT测定对良、恶性胸液的鉴别诊断具有重要的价值。     

HIV-1/AIDS患者血清铁蛋白与病情进展关系的研究

目的了解HIV-1／AIDS病人血清铁蛋白检测结果与HIV／AIDS患者病情进展的关系。方法使用化学发光法（CLIA）检测已确诊的24例HIV-1阳性患者血清铁蛋白，结合患者的临床资料和其他检验结果，对不同临床分期、贫血程度和消瘦程度的HIV／AIDS患者的血清铁蛋白水平进行分析。结果在24例HIV／AIDS病人中，不同临床分期的患者血清铁蛋白水平比较有统计学差异，AIDS组明显高于ARC组，ARC组明显高于AS组；在不同消瘦程度的组别中存在统计学差异，中度和重度体重减轻的患者铁蛋白水平明显高于体重正常和体重轻度、中度减轻的患者；在不同的贫血组别中存在明显差异，中度和重度贫血组的铁蛋白水平明显高于无贫血患者和轻度贫血者。结论在不同的疾病进展阶段，铁蛋白的水平存在着显著性差异，铁蛋白水平随着病情的进展而升高。铁蛋白是提示HIV／AIDS进展的灵敏指标。     

Trans-placental exchanges of serum iron,hemoglobin and ferritin at the end of gestation in the human species

This study relates to the determination of the concentrations of trans-placental exchanges of iron, hemoglobin and ferritin at the end of gestation according to the maternal martial status and the birth weight of the newborn. A total of 97 mother-newborn couples were included for this study in Algeria. Hemoglobin, iron and ferritin levels were measured in the maternal anticubital vein as well as in the umbilical vein after cord clamping. The mothers were classified into two groups, according to their hemoglobin and serum ferritin concentrations, into anemic and non-anemic mothers. Newborns were classified into three groups according to their birth weights: nnormotrophs, hypertrophes and hypotrophs. The prevalence of iron deficiency anemia in our women was 40.2%. All concentrations of trans-placental exchange of hemoglobin, iron and ferritin were positive; and no significant difference was observed in the mean values of exchange of the parameters studied between anemic and non-anemic mothers. The hemoglobin trans-placental exchange concentrations were significantly higher (P < 0.001) and for ferritin were significantly lower (P < 0.05) in hypotrophic neonates compared to normotrophs and hypertrophies; on the other hand for the iron were similar. Our results confirm the adaptive metabolic function of the placenta to ensure normal growth of the fetus.     

Iron status in low birth weight infants on breast and formula feeding

Iron status in 15 low birth weight infants, 1000–2499 g, on breast feeding was studied longitudinally for the first 6 months of age, and the findings compared to those of 30 low birth weight infants receiving a proprietary iron-fortified formula. The two groups received no iron supplement until they developed iron deficiency. The incidence of iron deficiency at 6 months was significantly greater in the breast-fed group than in the formula-fed group (86% v 33%). The breast-fed group had significantly lower serum ferritin and hemoglobin values after 4 months of age. The findings indicate that breast-fed low birth weight infants have a higher risk of developing iron deficiency and should receive iron supplementation from 2 months of age.Abbreviations TIBC total iron-binding capacity - MCV mean corpuscular volume     

Serum iron,copper, zinc,ferritin, and ceruloplasmin after intense heat exposure

Summary Twelve voluntary adult subjects twice took a 30-min sauna bath, at a temperature of 80‡ C with a 30-min rest between each, every 12 h for 1 week. Measurements of serum iron, copper, zinc, ferritin and ceruloplasmin were performed before the experiment, after the first and second 30 min in the sauna and at the end of the week. The first two sauna baths did not significantly change the concentrations of the trace elements measured. After the week the mean serum copper concentration had decreased from 15.0 (SD 1.7) Μmol·l⁻¹ to 13.5 (SD 2.0) Μmol·l⁻¹ (p<0.02). The mean zinc concentration decreased from 13.8 (SD 2.4) Μmol·l⁻¹ to 9.8 (SD 1.8) Μmol·l⁻¹ (p<0.001) during the week of the experiment. At the beginning of the study period two subjects had zinc concentrations below the reference values and after the week nine subjects had zinc concentrations below the reference values. The concentration of serum ferritin decreased from 142.2 (SD 103) Μg·l⁻¹ to 111.3 (SD 89) Μg·l⁻¹ (p<0.02) whereas the values of ceruloplasmin remained unchanged. Our findings confirm the earlier suggestion that heavy exposure to heat can cause a loss of some trace elements, especially zinc. Supported by the Sigrid Juselius Foundation.     

A case of cytophagic histiocytic panniculitis: Successful treatment of recurrent attacks with steroid pulse therapy and oral cyclosporin A

Summary We report a 35-year-old man, who had been diagnosed with Weber-Christian disease, presented with acute onset of high fever, malaise, jaundice and hepatosplenomegaly with subcutaneous nodules. Laboratory tests showed elevated serum ferritin and liver enzymes, especially lactate dehydrogenase (LDH), with pancytopenia and coagulation abnormalities. Peripheral blood and bone marrow examinations showed erythro-, leuko- and thrombo-phagocytic histiocytes and macrophages. The patient developed the same clinical features seven years ago. Based on diagnosis of cytophagic histiocytic panniculitis, the patient was treated with steroid pulse therapy and oral cyclosporin A. The combination therapy caused a marked improvement in the clinical condition.     

Regulatory failure of serum prohepcidin levels in patients with hepatitis C

BACKGROUND/AIMS: Elevated serum ferritin and hepatic iron concentrations are frequently observed in chronic hepatitis C (CHC), which may be related to hepcidin. Because the role of hepcidin in CHC patients remains unknown, we aimed in this study to generate some information about hepcidin in CHC. METHODS: To determine whether serum hepcidin correlates with markers of iron status in patients with viral hepatitis, we measured serum prohepcidin levels in patients with hepatitis C virus (HCV) and hepatitis B virus (HBV) infection and in healthy controls. RESULTS: Serum prohepcidin and ferritin levels were negatively correlated (r=-0.182, P=0.037) in HCV patients and positively correlated in HBV patients and in healthy controls. The total iron scores in liver specimens from HCV patients were also negatively correlated (r=-0.403, P=0.013). Serum prohepcidin levels in patients with liver cirrhosis (LC) were significantly lower than in patients with chronic hepatitis (CH). In both CH and LC patients, serum prohepcidin levels were significantly lower in HCV patients than in HBV patients. CONCLUSION: Failure of homeostatic regulation of serum prohepcidin concentrations may be induced by HCV infection, resulting in elevation of serum ferritin levels, which leads to the progression of liver injury by iron overload in CHC patients.     

原发性肝癌患者CEA、AFP、CA199和铁蛋白检测的意义

目的：探讨联合检测血清癌胚抗原（CEA）、甲胎蛋白（AFP）、糖蛋白抗原199（CA199）和铁蛋白（Fer）对原发性肝癌（PLC）的诊断价值。方法在31例确诊的 PLC 患者和31例同期健康体检者,联合检测血清 CEA、AFP、CA199和 Fer 水平,对比分析其检测的意义。结果 PLC 患者血清 CEA[（28.12±5.76）μg/L、AFP（307.23±23.67）μg/L）、CA199（158.53±11.42） U/ml 和Fer（457.82±22.31）μg/L）水平较健康对照组[分别为（2.94±2.16）μg/L、（10.12±5.24）μg/L、（13.32±2.86）U/ml 和（116.24±16.19）μg/L]明显升高,差异显著,具有显著统计学意义（P＜0.01）;四者联合检测诊断原发性肝癌的阳性率可达93.6%,与 CEA、AFP、CA199和 Fer 单独检测的敏感性（分别为67.8%、74.2%、77.4%和80.6%）相比,均有显著提高（P〈0.01）。结论联合检测血清CEA、AFP、CA199和 Fer 能显著提高原发性肝癌的诊断率。