两种方法腭向移动上颌第二磨牙效果比较

目的：研究安氏Ⅰ类错患者中,分别采用微型种植体作支抗与口内支抗腭向移动上颌第二磨牙进行比较,以评价两种方法各自的特点。方法：将20例成人患者随机分成两组,分别采用两种方法腭向移动上颌磨牙。测量上颌第二磨牙在移动速度和颊舌向、垂直方向的位置变化,以衡量磨牙的位置改变。结果：种植体作支抗组上颌第二磨牙平均腭向移动3.8mm,疗程4.4个月,平均移动速度0.86mm/月,磨牙垂直向压低0.45mm。对照组上颌第二磨牙平均腭向移动4.0mm,疗程6.2个月,平均移动速度0.65mm/月,磨牙垂直向伸长1.86mm。结论：两种方法比较,种植体的支抗更强,磨牙移动速度更快。二者磨牙的移动方式有所区别。     

Vascular endothelial growth factor and its receptor expression during the process of fracture healing

Objective： To study the expression regularity of vascular endothelial growth factor （VEGF） during the process of fracture healing, and the type of VEGF receptor expressed in the vascular endothelial cells of the fracture site.
Methods： The fracture model was made in the middle part of left radius in 35 rabbits. The specimens from the fracture site were harvested at 8, 24, 72 hours and 1, 3, 5, 8 weeks, and then fixed, decalcified, and sectioned frozenly to detect the expression of VEGF and its receptor at the fracture site by in situ hybridization and immunochemical assays.
Results： VEGF mRNA and VEGF expression was detected in many kinds of cells at the fracture site during 8 hours to 8 weeks after fracture. Fltl receptor of VEGF was found in the vascular endothelial cells at the fracture site during 8 hours to 8 weeks after fracture, and strong expression of flkl receptor was detected from 3 days to 3 weeks after fracture.
Conclusions： The expression of VEGF and fltl receptor appears during the whole course of fracture healing, especially from 1 to 3 weeks. Flkl receptor is highly expressed in a definite period after fracture. VEGF is proved to be involved in the vascular reconstruction and fracture healing.     

乙型肝炎病毒表面抗原清除的相关因素研究进展

血清乙型肝炎病毒表面抗原（HBsAg）阳性是乙型肝炎病毒（HBV）感染的标志,而HBsAg清除是慢性乙型肝炎（CHB）最接近临床治愈的一个指标。HBsAg清除受宿主、病毒及抗病毒药物等因素的影响。该文就近年来关于CHB患者HBsAg清除的相关因素的研究进展作了综述。     

肝移植术后早期脂肪乳剂支持治疗对移植肝功能影响的临床研究

目的　研究含脂肪乳剂的肠外营养 (TPN)对肝移植受体肝脏功能的影响。方法　选择2 0 0 1年 9月～ 2 0 0 4年 6月期间在我所肝移植中心住院行肝移植手术治疗的患者 ,取符合标准的 30例作为研究对象 ,随机分组 ,进行前瞻性的临床研究。肝移植术后 6h开始给予单糖或脂肪乳剂和单糖联合功能的TPN(分别为Glu对照组和MCT/LCT组 ) ,TPN期为 7d ,期间严格禁食。于TPN后第 1、4、7、10、30、90及 180天收集标本 ,检测血ALT、AST、GGT、TBil及DBil。结果　TPN支持后MCT/LCT和Glu组ALT、AST、GGT、TBil及DBil水平均呈现下降趋势 ,与单糖组相比 ,脂肪乳组降低迅速。结论　含脂肪乳的TPN较单糖TPN更有利于促进移植肝早期功能恢复     

Erfahrungen mit der gefäßgestielten Fibula in der Rekonstruktion von ossären Defekten bei primär malignen Knochentumoren

To bridge large bone defects after resection of primary malignant bone tumors, an autologous free vascularized fibular graft was used in 31 patients (15 x upper limb, 16 x lower limb). The median bone defect measured 16 cm (7-29.5 cm). At the lower extremity the vascularized fibular transplant was reinforced with an allograft and different osteosyntheses. At the upper limb stabilization of the transplant was obtained exclusively by plate osteosynthesis or condylar plate. Applications and the authors' experiences are described and discussed in terms of clinical outcome, graft union, functional outcome, and complications for each localization. After a median of 48 months, ten complications at the upper limb and eight complications at the lower limb, respectively, were seen requiring secondary surgical revision. Major complications such as perioperative deaths or secondary amputations were not observed. Functional evaluation showed better results for the lower than for the upper extremity, due mainly to en bloc resection of proportionally large amounts of soft tissues around the shoulder girdle for local tumor control. Despite the demanding operative procedure and a large number of controllable complications, the good functional outcome and high patient satisfaction indicate that the free vascularized fibular graft is an option for limb-sparing surgery of primary malignant bone tumors.     

A short time interval between the neurologic index event and carotid endarterectomy is not a risk factor for carotid surgery

Objective

Current guidelines recommend that carotid endarterectomy (CEA) be performed as early as possible after the neurologic index event in patients with 50% to 99% carotid artery stenosis. However, recent registry data showed that patients treated ≤48 hours had a significantly increased perioperative risk. Therefore, the aim of this single-center study was to determine the effect of the time interval between the neurologic index event and CEA on the periprocedural complication rate at our institution.

Reanimationsregister der Arbeitsgemeinschaft Leitender kardiologischer Krankenhausärzte

Zusammenfassung  Die Quote der überlebenden Patienten nach kardiopulmonaler Reanimation liegt in den meisten Untersuchungen unter 20%. Um diese Quote zu verbessern, ist zunächst eine Statuserhebung nötig, die die verbesserungsbedürftigen Punkte erfasst. Entsprechend wurde ein Register aufgebaut, das an Kliniken der Arbeitsgemeinschaft leitender kardiologischer Krankenhausärzte (ALKK) Patienten mit kardiopulmonaler Reanimation sowohl innerhalb als auch außerhalb des Krankenhauses erfassen sollte. Bei diesen Patienten wurden die diagnostischen und therapeutischen Maßnahmen auf kardiologisch-internistischen Intensivstationen erfasst und insbesondere hinsichtlich der Prognose ausgewertet. Zwischen Januar 1999 und März 2000 wurden insgesamt 1144 Patienten aus 32 Kliniken der ALKK in das Reanimationsregister eingeschlossen. Nur 21% der reanimierten Patienten haben das primär versorgende Krankenhaus lebend verlassen. Neben dem Alter und weiteren Co-Morbiditäten bestimmten in erster Linie die Zeit vom Kreislaufstillstand bis zum Beginn der Reanimationsmaßnahmen und das primäre EKG die Prognose der Patienten. Um die Reanimationserfolge zukünftig zu verbessern, sind Strategien zum schnellstmöglichen Beginn der Reanimation wie die Schulung von Angehörigen oder die Verbreitung der Frühdefibrillation daher von großer Bedeutung.Mitautoren:   

A distinctive translocation carcinoma of the kidney [“rosette-like forming,” t(6;11), HMB45-positive renal tumor]

Objective  Recently, a novel renal carcinoma with specific clinical and histological characteristics and translocation t(6;11)(p21.1;q12 or q13) has been identified. We have found 11 cases in the literature, and we are adding another 3 cases. Materials and methods  Three cases were found in the Plzeň pathological register with approximately 15,000 cases of kidney tumors. There were two females and 1 male, aged 22, 24, and 39 years. Results  The sizes of the tumors were 40, 136, and 10 mm. Two tumors were found incidentally; the biggest one was self-palpated by a 24-year-old pregnant patient. Patients are without any signs of disease 42, 20, and 17 months after surgery. Conclusion  This tumor is a distinctive and rare translocation carcinoma of the kidney [t(6;11), HMB45 positive]. All cases with known clinical data arose in younger people. The malignant potential is probably low. The work was supported by Czech government research project MSM 0021620819.