Successful Eradication of Helicobacter pylori as Determined by C-Urea Breath Test Does Not Alter Fibrinogen and Acute Phase Response Markers

In this study we examined in 100 patients testing positive for Helicobacter pylori infection whether successful eradication therapy with pantoprazole, clarithromycin, and metronidazole alters fibrinogen and other acute phase response markers. Of 100 patients, only 11 showed a fibrinogen level above 300 mg/dL. Successful eradication proven by the ¹³C-urea breath test does not alter acute phase response markers. These findings indicate that Helicobacter pylori infection is unlikely to affect atherosclerosis unfavourably via acute phase response.     

Eradicating diseases: The effect of conditional cash transfers on vaccination coverage in rural Nicaragua

Despite significant global efforts to improve vaccination coverage against major childhood diseases, vaccination rates are below 90%. To eradicate diseases such as measles, however, vaccination rates close to 95% are needed. We use a randomized experiment to investigate the effect of a demand incentive, a conditional cash transfer program, in improving vaccination coverage in rural Nicaragua. Double-difference estimates show the program led to large increases in vaccination coverage, and these resulted in vaccination levels greater than 95% for some vaccines. Effects were especially large for children who are typically harder to reach with traditional supply-side interventions.     

功能性消化不良与幽门螺杆菌根除治疗

幽门螺杆菌（H．pylori）阳性功能性消化不良（FD）或非溃疡性消化不良（NUD）患者几乎均有慢性和（或）急性活动性炎症的组织学改变，使FD与慢性胃炎的鉴别更为闲难．亦影响了FD患者根除H．pyZo一治疗的研究。罗马Ⅲ诊断标准是以症状学为主的诊断标准，FD仅发生于具有心理调节障碍的特殊易感群体，患者存在中枢神经系统的高敏感性、脑-肠轴调控功能异常以及某些神经介质和神经肽类物质分泌异常．并显示有遗传特征。根除Hpylori可能对部分H．pylori阳性FD患者有益，在仔细评估患者利益和风险的情况下．可考虑对FD患者行根除H．pylori治疗。     

Standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori eradication

AIM: To compare the effectiveness of standard triple, bismuth pectin quadruple and sequential therapies for Helicobacter pylori (H. pylori ) eradication in a randomized, double-blinded, comparative clinical trial in China. METHODS: A total of 215 H. pylori -positive patients were enrolled in the study and randomly allocated into three groups: group A (n = 72) received a 10-d bismuth pectin quadruple therapy (20 mg rabeprazole bid , 1000 mg amoxicillin bid , 100 mg bismuth pectin qid , and 500 mg levofloxaci...     

丹东市2006～2011年AFP监测系统运转情况分析

目的 分析丹东市2006～2011年AFP监测系统运转情况.方法 对丹东市所辖县(市)区AFP病例报告情况进行统计分析.结果 丹东市连续6年AFP监测质量主要评价指标均达到目标要求.6年报告AFP病例28例,＜15岁儿童报告发病率6年分别为1.41/10万、1.40/10万、1.57/10万、1.64/10万、1.59/10万和2.32/10万.男女性别比1.8∶1;月报告病例7月、8月、9月较多,占全年60.71％;未进行OPV免疫和未全程免疫儿童1例,占3.57％;AFP病例在县、乡级医疗机构就诊率最高(71.43％),报告率为30.78％.结论 为维持无脊灰状态,仍需提高和保持儿童OPV的免疫覆盖率,同时加强监测系统的管理,加大对县、乡、村医疗机构临床医生的培训力度,保持AFP监测系统的敏感性、及时性、完整性.     

根除幽门螺杆菌治疗慢性胃炎的疗效观察

目的探讨幽门螺杆菌(Hp)根除治疗在慢性胃炎治疗过程中的临床疗效。方法经胃镜、组织病理学检查和幽门螺杆菌检测确诊为幽门螺杆菌相关性胃炎患者99例分为研究组49例和观察组50例,并以同期53例非幽门螺杆菌相关性胃炎患者作为阴性对照组。研究组给予正规的根除幽门螺杆菌三联治疗,其他各组的基本治疗相同。分析每个组治疗前和治疗后4周、1年～1年6个月随访结束时的症状体征、胃镜检查和组织病理学检查结果。结果治疗结束后4周研究组的炎症严重程度和活动度都比观察组的轻(P<0.05)。研究组的炎症严重程度比治疗前明显好转(P<0.05),观察组则无显著性差异(P>0.05)。研究组的复发率比观察组和阴性对照组的都低(P<0.05)。结论对幽门螺杆菌相关性胃炎患者进行正规的根除幽门螺杆菌治疗可以提高慢性胃炎的临床治疗效果,具有非常重要的临床意义。     

Therapy of gastric mucosa associated lymphoid tissue lymphoma

Gastric mucosa associated lymphoid tissue （MALT） lymphoma has recently been incorporated into the World Health Organization （WHO） lymphoma classification, termed as extranodal marginal zone B-cell lymphoma of MALT-type. In about 90% of cases this lymphoma is associated with H pylori infection which has been dearly shown to play a causative role in lymphomagenesis. Although much knowledge has been gained in defining the clinical features, natural history, pathology, and molecular genetics of the disease in the last decade, the optimal treatment approach for gastric MALT lymphomas, especially locally advanced cases, is still evolving. In this review we focus on data for the therapeutic, stage dependent management of gastric MALT lymphoma. Hence, the role of eradication therapy, surgery, chemotherapy and radiotherapy is critically analyzed. Based on these data, we suggest a therapeutic algorithm that might help to better stratify patients for optimal treatment success.     

含益生菌序贯疗法作为根除幽门螺杆菌二线疗法的临床观察

目的对比含益生菌的短程四联序贯疗法与标准四联补救疗法作为根除幽门螺杆菌（helicobacter pylori,Hp）失败后二线疗法的疗效、不良反应发生率、溃疡愈合质量及胃黏膜炎症改善情况。方法将86例纳入本研究的Hp感染者随机分为两组：标准疗法组予标准四联疗法,疗程2周,序贯疗法组先予双歧三联活菌制剂治疗2周后,再予标准四联疗法,共7d,此后均服用埃索美拉唑镁肠溶片治疗4周,分别比较两组Hp根除率、不良反应发生率、溃疡愈合质量及胃黏膜炎症情况。结果两组Hp根除率在意愿（intention—to—treat,ITT）分析和按方案（per—protocol,PP）分析中,均无统计学意义;序贯疗法组不良反应发生率比标准疗法组低（1212％VS 31．0％）,序贯疗法组溃疡愈合质量比标准疗法组高（75．6％VS52．4％）,差异有统计学意义（P〈0．05）;两组在治疗后胃黏膜炎症均得到明显改善,且治疗后两组之间胃黏膜炎症特别是Hp根除后胃黏膜炎症存在差异,差异有统计学意义（P〈O．05）. 结论含益生菌的四联序贯疗法与标准四联疗法相比,Hp根除率无明显差异,但可减少不良反应发生率、改善溃疡愈合质量及胃黏膜炎症情况。     

2种治疗方案根除幽门螺杆菌的疗效观察

目的:比较2种根除幽门螺杆菌(Hp)方案的优劣。方法:将197例因各种上消化道症状行胃镜检查并14C-尿素呼气阳性的患者,随机分为A、B组(均符合根除Hp的条件及排除条件)。A组109例,给予雷贝拉唑10mg,阿莫西林-克拉维酸钾分散片(2:1)2片,甲硝唑0.4g;B组88例,给予雷贝拉唑10mg,阿莫西林1g,甲硝唑0.4g。2组给药方法均为每日2次,连用7d。总疗程结束后2周,再行内镜和14C-尿素呼气试验,判断Hp的根除效果。结果:A组根除率为88.07%,B组为73.90%。2组比较,差异有统计学意义(P<0.05)。结论:2种根除Hp的方案中,A组Hp根除率显著高于B组。