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61.
水蛭注射液对大白鼠血小板粘附和血小板聚集功能的影响 总被引:6,自引:1,他引:5
目的 探讨水蛭注射液对大白鼠血小板粘附性和聚集性的影响。方法 采用大白鼠 2 4只 ,随机分成两组 ,实验组给药 ,对照组以实验组同样的方法和剂量给予生理盐水 ,5d后由颈总动脉取血 ,做血小板粘附性和聚集性试验。结果 水蛭注射液对大鼠血小板粘附性和聚集性具有显著的抑制作用 ,实验组与对照组抑制率有显著的统计学意义 (P <0 0 0 1)。结论 水蛭注射液能够抑制大白鼠血小板的粘附和聚集。 相似文献
62.
Michelle Lucinda DeOliveira M.D. Tarcisio Triviño M.D. Ph.D. Gaspar de Jesus Lopes Filho M.D. Ph.D. 《Journal of gastrointestinal surgery》2006,10(8):1140-1143
Carcinoma of the papilla of Vater is classified as periampullary cancer representing 5% of all gastrointestinal tract malignancies.
Early and accurate diagnosis is important for those patients with a tumor of the papilla, as the prognosis is more favorable
than in other periampullary neoplasms. Endoscopically obtained biopsies from suspicious papillae can detect an early tumor,
although even for skilled pathologists it is often difficult to differentiate carcinomas from noninvasive lesions on the basis
of forceps biopsies. The purpose of this study was to assess the preoperative diagnostic accuracy of duodenoscopy appearance
and biopsy in all cases with suspicion of tumor. Thirty patients with suspicion of carcinoma of the papilla of Vater and with
final diagnosis established by pancreatoduodenectomy were included in this retrospective study. In each case, a comparison
was made between endoscopic biopsy and duodenoscopic appearance. Duodenoscopic appearance sensitivity and accuracy for malignancy
were 86% and 83%, respectively, whereas endoscopic biopsy sensitivity and accuracy were 65% and 67%, respectively. Although
preoperative diagnosis of carcinoma of the papilla of Vater is useful for making therapeutic decisions, the diagnostic value
of the endoscopic appearance was superior to endoscopic biopsy in this series.
Presented at the 2003 American Hepato-Pancreato-Biliary Association Congress, Miami, Florida, February 27-March 3, 2003.
Supported by FADA-CAPES/PROP 200J (M.L.D.). 相似文献
63.
Intra-operative quick insulin assay to confirm complete resection of insulinomas guided by selective arterial calcium injection (SACI) 总被引:1,自引:0,他引:1
Oliver Gimm Evelyn König Phuong Nguyen Thanh Michael Brauckhoff Wolfram Karges Henning Dralle 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(6):679-684
Background and aims Insulinomas are rare endocrine disorders. Pre-operatively, conventional imaging techniques often fail to localise the tumor.
In addition, due to the lack of quick insulin assays, intra-operative confirmation of complete resection was impossible until
recently.
Materials and methods Six patients with biochemical evidence of an insulinoma underwent pre-operative localisation studies and selective arterial
calcium injection (SACI). In addition, insulin was measured before surgery and every 10–15 min after resection of the tumor
using a quick insulin assay.
Results Pre-operative localisation studies identified the tumor correctly as follows: endosonography: three of four, magnetic resonance
imaging: two of four and SACI: six of six. Tumors in the head and body were enucleated while those in the tail were resected
(n = 2, each). Those three patients, in whom magnetic resonance imaging and/or endosonography could localise the tumors pre-operatively,
underwent laparoscopic surgery while the remaining three patients underwent open surgery. Intra-operatively, insulin dropped
to normal levels within 20 min in all cases. After a follow-up of 0.8–3 years, all patients remained biochemically cured.
Conclusions Pre-operatively, SACI appears to be a very sensitive localisation technique and may be most helpful in guiding the surgeon
if conventional imaging techniques fail to localise the tumor. Complete removal of an insulinoma can be reliably predicted
using a quick insulin assay.
This paper was presented at the 2nd Biennial Meeting of the European Society of Endocrine Surgeons (ESES), May 18–20, 2006,
Krakow, Poland. 相似文献
64.
Hirotaka Itakura Shoji Kishi 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2009,247(8):1147-1150
Purpose To determine the efficacy of intravitreal injection of sulphur hexafluoride (SF6) gas for reducing persistent subfoveal fluid
after scleral buckling surgery for macula-off rhegmatogenous retinal detachments.
Methods We injected 0.3 ml of SF6 gas into the vitreous cavity of two eyes of two patients with persistent macular retinal detachment
3 and 5 months after successful scleral buckling. Optical coherence tomography was performed before and after surgery.
Results Subfoveal fluid was displaced peripheral to the fovea immediately after gas injection and the fluid was absorbed gradually
in both eyes.
Conclusions Persistent subfoveal fluid after scleral buckling may be treated with intravitreal SF6 gas injection.
The authors have no proprietary interest in any aspect of this report 相似文献
65.
66.
蟾酥注射液对小鼠S180和人结肠癌HT-29裸鼠移植性肿瘤的影响 总被引:6,自引:0,他引:6
目的研究蟾酥注射液对小鼠移植性肿瘤 S180和人结肠癌 HT-29裸鼠移植性肿瘤的抑制作用.方法分别用小鼠 S180和人结肠癌 HT-29裸鼠两种荷瘤小鼠模型,观察药物对上述肿瘤的抑瘤作用,并镜下观察后者细胞凋亡情况.结果与荷瘤阴性对照组比较,蟾酥注射液各剂量组对小鼠 S180抑瘤率( IR)为 19.1%~38.2%(P<0.05),呈量效关系;而对人结肠癌 HT-29裸鼠移植性肿瘤的 IR为 9.5%~15.8%(P>0.05),也呈量效关系,但差异均未见统计学意义;环磷酰胺则能显著抑制小鼠 S180和 HT-29细胞裸鼠移植性肿瘤的生长( IR分别为70.7%和 67.1%, P<0.01),镜检可见其有显著促进肿瘤细胞凋亡作用;未发现实验药物出现明显的毒副作用.结论该实验所用的蟾酥注射液,对小鼠 S180有抑制作用,而对人结肠癌 HT-29裸鼠移植性肿瘤,则作用不明显,表明不同类型的肿瘤对其敏感性不同. 相似文献
67.
68.
解剖因素致单纯鼻源性头痛的鼻内镜手术 总被引:2,自引:0,他引:2
目的 :探讨鼻内镜手术治疗解剖因素致单纯鼻源性头痛的方法和疗效。方法 :鼻内镜下切除或矫正鼻腔鼻窦区异常解剖结构。结果 :单一因素中鼻丘气房肥大 ,泡性中、上鼻甲及中隔偏曲分别为 7例、10例、12例 ,术后治愈率达 71.4 3%、6 0 .0 0 %、6 6 .6 7% ,合计治愈率达 6 5 .5 2 %。多因素者 4 4例 ,术后治愈率达38.6 4% ,与单一因素差异有显著性 (P <0 .0 2 5 )。患者治疗有效率达 10 0 %。结论 :鼻内镜手术是治疗解剖因素致单纯鼻源性头痛的有效方法之一 ,单一因素者疗效更佳。 相似文献
69.
70.
Wong Joseph Kuu Wei-Youh Burke Ronald Johnson Robert Wood Ray W. 《Pharmaceutical research》1995,12(1):144-148
The primary objective of this work was to establish a method to simulate the plasma levels of cilastatin, a model drug, following an intravenous in-line delivery scheme. In-vivo data in dogs obtained from this work were used to demonstrate the validity of the proposed approach. The in-line drug delivery system consists of a drug containing device which is placed between a large volume parenteral and a patient. Numerous advantages have been identified for this automatic in-line reconstitution delivery system. The numerical convolution integral algorithm was used in this work to perform plasma profile simulation. The results indicated that the simulated cilastatin plasma profile following in-line delivery closely agreed with the in-vivo data. 相似文献