全文获取类型
收费全文 | 31497篇 |
免费 | 2458篇 |
国内免费 | 2153篇 |
专业分类
耳鼻咽喉 | 1193篇 |
儿科学 | 209篇 |
妇产科学 | 496篇 |
基础医学 | 917篇 |
口腔科学 | 223篇 |
临床医学 | 2969篇 |
内科学 | 4806篇 |
皮肤病学 | 261篇 |
神经病学 | 728篇 |
特种医学 | 699篇 |
外国民族医学 | 6篇 |
外科学 | 3226篇 |
综合类 | 5514篇 |
现状与发展 | 3篇 |
预防医学 | 1114篇 |
眼科学 | 855篇 |
药学 | 8126篇 |
31篇 | |
中国医学 | 3863篇 |
肿瘤学 | 869篇 |
出版年
2024年 | 75篇 |
2023年 | 488篇 |
2022年 | 863篇 |
2021年 | 1226篇 |
2020年 | 1093篇 |
2019年 | 949篇 |
2018年 | 1138篇 |
2017年 | 1097篇 |
2016年 | 1359篇 |
2015年 | 1325篇 |
2014年 | 2759篇 |
2013年 | 2523篇 |
2012年 | 2575篇 |
2011年 | 2705篇 |
2010年 | 2092篇 |
2009年 | 1736篇 |
2008年 | 1638篇 |
2007年 | 1680篇 |
2006年 | 1487篇 |
2005年 | 1277篇 |
2004年 | 932篇 |
2003年 | 815篇 |
2002年 | 701篇 |
2001年 | 586篇 |
2000年 | 433篇 |
1999年 | 380篇 |
1998年 | 284篇 |
1997年 | 247篇 |
1996年 | 239篇 |
1995年 | 182篇 |
1994年 | 170篇 |
1993年 | 115篇 |
1992年 | 93篇 |
1991年 | 123篇 |
1990年 | 112篇 |
1989年 | 70篇 |
1988年 | 77篇 |
1987年 | 59篇 |
1986年 | 39篇 |
1985年 | 63篇 |
1984年 | 53篇 |
1983年 | 40篇 |
1982年 | 40篇 |
1981年 | 32篇 |
1980年 | 20篇 |
1979年 | 28篇 |
1978年 | 26篇 |
1977年 | 20篇 |
1976年 | 11篇 |
1975年 | 13篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
刘彦鹏 《中国卫生标准管理》2020,(5):95-97
目的探讨参附注射液对老年重症肺炎疗效及N末端B型利钠肽原(NT-pro BNP)的影响。方法选择2016年6月—2019年6月医院收治的老年重症肺炎患者80例,以随机数表法将其分为两组,即对照组与研究组各40例。对照组患者接受常规对症治疗,研究组在此基础上应用参附注射液治疗。对比两组临床疗效,治疗前与治疗3 d、5 d时血浆NT-pro BNP水平,以及不良反应情况。结果研究组治疗的总有效率为95.00%,高于对照组77.50%(P<0.05)。治疗后3 d与5 d时研究组血浆NT-pro BNP水平均低于对照组(P<0.01)。两组治疗期间均未见明显的药物不良反应。结论参附注射液能够有效提高老年重症肺炎患者的疗效,调节脑钠肽水平。 相似文献
22.
《药学学报(英文版)》2020,10(7):1294-1308
A great challenge in multi-targeting drug discovery is to identify drug-like lead compounds with therapeutic advantages over single target inhibitors and drug combinations. Inspired by our previous efforts in designing antitumor evodiamine derivatives, herein selective histone deacetylase 1 (HDAC1) and topoisomerase 2 (TOP2) dual inhibitors were successfully identified, which showed potent in vitro and in vivo antitumor potency. Particularly, compound 30a was orally active and possessed excellent in vivo antitumor activity in the HCT116 xenograft model (TGI = 75.2%, 150 mg/kg, p.o.) without significant toxicity, which was more potent than HDAC inhibitor vorinostat, TOP inhibitor evodiamine and their combination. Taken together, this study highlights the therapeutic advantages of evodiamine-based HDAC1/TOP2 dual inhibitors and provides valuable leads for the development of novel multi-targeting antitumor agents. 相似文献
23.
Michael A. Gibney David Fitz-Patrick David C. Klonoff Shahista Whooley Betty Lu Wen Yue 《Current medical research and opinion》2020,36(10):1591-1600
Abstract
Objective
Two similarly designed studies compared user experiences with a second-generation extra-thin-wall, 5-bevel 32?G?×?4?mm pen needle (PN) with redesigned hub versus four thinner commercially available PNs. 相似文献24.
Takashi Murakami Naoto Sakamoto Akihito Nagahara 《Journal of gastroenterology and hepatology》2019,34(10):1685-1695
Sessile serrated adenoma/polyps (SSA/Ps) are early precursor lesions in the serrated neoplasia pathway, which results in BRAF‐mutated colorectal carcinomas with not only high levels of microsatellite instability but also microsatellite stable. SSA/Ps with advanced histology, including cytological dysplasia or minimally invasive carcinomas, are important lesions because SSA/Ps are considered major contributors to “interval cancers” and these lesions can rapidly become dysplastic or invasive carcinomas. Clinicopathologically, SSA/Ps with dysplasia or invasive carcinoma were associated with advanced age, female sex, and proximal colon. Although SSA/Ps with submucosal invasive carcinoma were smaller and invaded less deeply into the submucosal layer than conventional tubular adenomas with submucosal invasive carcinoma, SSA/Ps with submucosal invasive carcinoma frequently had a mucinous component and exhibited a higher potential for lymphatic invasion and lymph node metastasis. In an SSA/P series, endoscopic characteristics, including (semi)pedunculated morphology, double elevation, central depression, and reddishness, may help accurately diagnose SSA/Ps with advanced histology. Removal of SSA/Ps with dysplasia or invasive carcinoma was recommended. Endoscopic treatment such as endoscopic mucosal resection or endoscopic submucosal dissection is useful for those lesions. However, surgical resection with lymph node dissection might be indicated when SSA/Ps with invasive carcinoma are endoscopically suspected, because these have the high risk of lymph node metastasis. Greater awareness may promote further research into improving the detection, recognition, and complete resection rates of SSA/Ps with dysplasia or invasive carcinoma and reduce the interval cancer rates. 相似文献
25.
High-pressure injection injuries (HPII) caused by water swelling sealant are rare at present. The patient generally has small-sized skin lesions, and the misleadingly benign presentation may cause delayed treatment at the early stage of management. In addition, radiographic examination may be underestimated. Subsequently, the inadequate surgical intervention may cause tissue necrosis and poor prognosis. Furthermore, the early recognition of water swelling sealant injected into tissue and emergent surgical intervention are the key to successful management for the patient with HPII caused by injecting water swelling sealant to tissue. 相似文献
26.
杨永磊 《长春中医药大学学报》2015,(4):749-750
目的 观察参麦注射液治疗冠心痛的临床效果.方法 选取我院2013年4月-2014年1月间收治的冠心病患者94例,依据治疗方案不同分为治疗组48例,对照组46例,2组患者入院均根据病情给予能量合剂、血管扩张剂、减轻心脏负荷药物,并进行对症、溶栓及抗心律失常等常规治疗,治疗组患者在常规治疗的基础上给予参麦注射液静滴治疗,1次/d,用药2周为1疗程;于治疗2疗程后观察治疗效果,并对比2组患者临床症状、心电图改善情况及红细胞超氧化物歧化酶(E-SOD)平均活性,血浆过氧化脂质(P-LPO)、红细胞过氧化脂质(E-LPO)含量变化.结果 治疗组治疗后总有效率显著高于对照组(P<0.05);治疗组胸闷、心悸、心绞痛及ST段下移、T渡低平或倒置患者改善率显著均高于对照组(P<0.05);治疗组治疗后E-SOD活性显著高于对照组,P-LPO、E-LPO含量显著低于对照组(P<0.05).结论 参麦注射液可有效缓解冠心病患者临床症状,降低血中脂质过氧化物浓度,缓解心肌缺血状态. 相似文献
27.
28.
29.
30.