慢性支气管炎肺气肿中医辨证治疗效果观察

目的:观察运用中医辨证论治治疗慢性支气管炎肺气肿的临床疗效;方法:选取我院慢性支气管炎合并肺气肿患者180例,按照随机平行方法分为两组:观察组和对照组各90例,对照组患者进行控制感染及解痉平喘等常规内科治疗,观察组患者在常规西医内科治疗的基础上分为表寒内饮型、痰热内壅型以及肺肾阳虚型三种类型分别进行辨证论治,全部患者治疗30d;结果:治疗组患者总有效率为64.44%,对照组为27.78%,两组比较治疗组显著高于对照组(P0.01);结论:对慢性支气管炎肺气肿患者实施中医辨证治疗,可有效改善患者临床症状,提高治疗效果。     

Chemical and nutritional analysis of seeds from purple and white açaí (Euterpe oleracea Mart.)

Seeds from the purple and the white fruit produced by the Amazonian palm, Euterpe oleracea Mart., commonly called “açai”, were analyzed by solid state ¹H-decoupled ¹³C CPMAS and MAS NMR, solution NMR and LC–MS/MS. The goal was to distinguish the seeds from each colored fruit and determine their spectra for the first time. The seeds of each variety contained primarily glycosidic carbons, due to their cellulose and hemicellulose content. They also contained carbons due to CO, CC, as well as aliphatic carbons. The insoluble fiber found in açaí pulp is distinguishable from the seed of the fruit by its unique solid state ¹H-decoupled ¹³C CPMAS NMR spectra. The seed also contains fats (0.22–0.33%) not previously reported. The seed contains a mixture of saturated and unsaturated fats. There are also 3.38–4.70% total methanolic extractables, with no detectable cyanidin 3-O-glucoside or cyanidin 3-O-rutinoside, unlike the pulp which contains both cyanidins. When the NMR spectra of the white and purple açaí seeds are compared, it was possible to observe differences between these two açaí varieties, as well as differences between the composition of pulp of the fruit and its seed.     

电视胸腔镜下肺减容术治疗重度肺气肿6例

目的 评价电视胸腔镜下肺减容术治疗重度肺气肿的疗效。方法 对6例重度肺气肿进行胸腔镜肺减容术,其中同期双侧2例,单侧4例。切除一侧肺容积约25％-30％。结果 无手术死亡,随访3-17个月,FEV1和PaO2增加24.6％和8.3％。RV、TLC和气道阻力分别下降24．6％、20．3％、47．1％。结论 严重肺气肿患经肺减容术后呼吸困难缓解,生活质量改善。     

螺旋CT双相扫描在肺气肿诊断与功能评价中的价值探讨

目的：探讨螺旋CT双呼吸相扫描对肺气肿诊断与功能评价的价值。方法：50例健康志愿者和30例肺气肿患者行全肺双相扫描及局部感兴趣区HRCT薄层扫描,计算全肺、肺内各区双相肺容积减少百分比及CT临界值。结果：（1）50岁以上正常人双相肺容积减少百分比为45％－65％,重度肺气肿患者为20％－30％,中度患者为32％－48％;（2）肺气肿CT临界值为：深吸气相－953．30,深呼气相－914．62HU。结论：螺旋CT双相肺容积测定结合HRCT薄层扫描,对评估肺功能尤其是局部肺功能及诊断早期肺气肿有重大价值。     

弹性蛋白酶肺气肿表面活性物质蛋白A、B的基因表达

目的研究肺气肿发生、发展过程中表面活性物质蛋白A、B(SP-A、B)的基因表达变化.方法金黄地鼠气道一次性注入弹性蛋白酶,分别于注酶后的7、14、21、30、60和90天处死.动物右肺组织福尔马林灌注固定后,石蜡包埋、切片,分别行HE和抗SP-A、B的免疫组化染色,并进行显微-微机形态定量.左肺液氮冷冻后,保存于-70℃,异硫氰酸胍一步法提取总RNA,甲醛变性胶电泳,转移至尼龙膜.扩增、酶切质粒,并回收、32p标记SP-A、B DNA片断.最后,行Northern Blot,放射自显影后,测定光密度.结果 1.免疫组化显示注酶7～30天SP-A、B阳性细胞百分率逐步降低,其中,30天SP-A、B阳性细胞百分率与正常组有明显差异(P＜0.01),由30～90天SP-A、B阳性细胞百分率明显回升,但仍低于正常组.2.Northern Blot结果注酶30天SP-A和B mRNA量明显低于正常组,但是,到达90天后SP-A、B mRNA量基本与正常组无明显差异.结论肺气肿发病过程中SP-A、B基因表达的动态变化提示,表面活性物质蛋白A、B变化可能参与肺气肿的发生和发展.     

Diagnostic dilemma of gastric intramural air

Emphysematous gastritis and gastric emphysema remain the two most important differential diagnoses of intramural gastric air bubbles, both differing vastly in their clinical presentation, radiographic findings, management and prognosis. This report discusses a case of gastric emphysema along with the importance of reaching an accurate clinical diagnosis early in the disease course.     

Effect of Budesonide and Formoterol on Il-6 and Il-8 Release from Primary Bronchial Epithelial Cells

The aim of this study was to explore possible interactions between a glucocorticosteroid (budesonide) and a long-acting β₂-agonist (formoterol) on pro-inflammatory cytokine release.

Primary bronchial epithelial cells (PBEC) were stimulated with organic dust and incubated with budesonide, formoterol, and the combination of both drugs. Interleukin (IL)-6 and -8 in the supernatant was assessed by enzyme-linked immunosorbent assay (ELISA).

Formoterol increased the IL-6 release but did not influence the IL-8 release. Budesonide attenuated the IL-6 and IL-8 release, an inhibiting effect that was sustained, but not reinforced, by formoterol.