全文获取类型
收费全文 | 16602篇 |
免费 | 1438篇 |
国内免费 | 282篇 |
专业分类
耳鼻咽喉 | 19篇 |
儿科学 | 366篇 |
妇产科学 | 17篇 |
基础医学 | 2429篇 |
口腔科学 | 214篇 |
临床医学 | 1571篇 |
内科学 | 4752篇 |
皮肤病学 | 310篇 |
神经病学 | 137篇 |
特种医学 | 367篇 |
外科学 | 1807篇 |
综合类 | 2061篇 |
现状与发展 | 3篇 |
预防医学 | 450篇 |
眼科学 | 103篇 |
药学 | 1859篇 |
6篇 | |
中国医学 | 1789篇 |
肿瘤学 | 62篇 |
出版年
2024年 | 32篇 |
2023年 | 416篇 |
2022年 | 546篇 |
2021年 | 714篇 |
2020年 | 722篇 |
2019年 | 741篇 |
2018年 | 703篇 |
2017年 | 747篇 |
2016年 | 656篇 |
2015年 | 535篇 |
2014年 | 1093篇 |
2013年 | 2032篇 |
2012年 | 809篇 |
2011年 | 894篇 |
2010年 | 636篇 |
2009年 | 755篇 |
2008年 | 709篇 |
2007年 | 766篇 |
2006年 | 623篇 |
2005年 | 513篇 |
2004年 | 457篇 |
2003年 | 312篇 |
2002年 | 324篇 |
2001年 | 264篇 |
2000年 | 246篇 |
1999年 | 242篇 |
1998年 | 243篇 |
1997年 | 178篇 |
1996年 | 179篇 |
1995年 | 154篇 |
1994年 | 139篇 |
1993年 | 135篇 |
1992年 | 110篇 |
1991年 | 78篇 |
1990年 | 80篇 |
1989年 | 57篇 |
1988年 | 51篇 |
1987年 | 57篇 |
1986年 | 59篇 |
1985年 | 49篇 |
1984年 | 53篇 |
1983年 | 30篇 |
1982年 | 53篇 |
1981年 | 38篇 |
1980年 | 22篇 |
1979年 | 16篇 |
1978年 | 14篇 |
1977年 | 12篇 |
1976年 | 11篇 |
1975年 | 10篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
61.
Philippe Druet 《Journal of immunological methods》1992,150(1-2):177-184
62.
应用ELISA测定了54例类风湿性关节炎患者、99例非类风湿性关节炎患者以及100例正常人的血清Ⅱ型胶原抗体,结果阳性率分别为90.7%、0、0.54例类风湿性关节炎患者中有7例血清类风湿因子为阴性而Ⅱ型胶原抗体为阳性,且病程均在半年之内。结果表明:Ⅱ型胶原抗体的检测对类风湿性关节炎具有特异性诊断和早期诊断的临床意义。 相似文献
63.
Surgical Principles
Radical arthroscopic synovectomy of rheumatoid shoulder and elbow.
Revised Version from: Operat. Orthop. Traumatol. 4 (1992), 112–129 (German Edition). 相似文献
64.
Children With Chronic Physical Disorders: Maternal Reports of Their Psychological Adjustment 总被引:7,自引:4,他引:3
Wallander Jan L.; Varni James W.; Babani Lina; Banis Heather Tweddle; Wilcox Karen Thompson 《Journal of pediatric psychology》1988,13(2):197-212
Advances in biomedical science have resulted in dramatic improvementsin the medical care of chronically ill and handicapped children.Past measurement problems have resulted in a lack of clarityregarding the psychological adjustment of these children. Themothers of 270 chronically ill and handicapped children wereadministered the Child Behavior Checklist in an attempt to identifypatterns of behavioral functioning across six pediatric chronicdisorders: juvenile diabetes, spina bifida, hemophilia, chronicobesity, juvenile rheumatoid arthritis, and cerebral palsy.In general, it was found that children in all chronic disordergroups were perceived by their mothers as evidencing on theaverage more behavioral and social competence problems thanexpected based on norms for children in general. However, theirbehavioral and social adjustment was reported as better thanthat of a normative sample of children referred to mental healthclinics. There were essentially no differences between childrenwith different chronic disorders in terms of behavior problemsand social competence. The results were taken to support theview that these children were as a group at risk for adjustmentproblems. They were also discussed in terms of the noncategorialapproach, which suggests that similar psychosocial challengesare faced across pediatric chronic physical disorders. 相似文献
65.
Alexandros Kolokotronis Evanda Avramidou Thomas Zaraboukas Kalliopi Mandraveli Stella Alexiou Demetrios Antoniades 《Journal of oral pathology & medicine》2006,35(2):123-125
BACKGROUND: The use of immunosuppressive medication is a dominant risk factor for infection in patients with rheumatoid arthritis (RA). Methotrexate (MTX) is one of the traditional disease-modifying antirheumatic drugs. Adalimumab [a human anti-tumor necrosis factor-alpha (anti-TNF-alpha) monoclonal antibody] represent an important advance in the treatment of RA and has been recently come in use. TNF-alpha plays a role in the host defense against Mycobacterium tuberculosis and notably in granuloma formation. Infections occur at a high rate among those who use one or the combination of the two medications. METHOD: We examined a female patient that was referred to our department for evaluation and treatment of a granular lesion on the soft palate and uvula, complaining of mild dysphagia. The patient was treated for 4 months with MTX and adalimumab for RA before the oral lesion appeared. RESULTS: The histopathological examination of a specimen of the oral lesion, taken by biopsy, showed a chronic inflammation characterized by tuberculous granulomas. Polymerase chain reaction test and culture of a new specimen was positive for M. tuberculosis. CONCLUSIONS: The therapeutic use of MTX or/and adalimumab for the treatment of RA or few others diseases, can cause oral tuberculosis. 相似文献
66.
T. C. WASCHER J. HERMANN R. BREZINSCHEK H. P. BREZINSCHEK M. WILDERS-TRUSCHNIG F. RAINER G. J. KREJS 《European journal of clinical investigation》1994,24(1):73-75
Abstract. Cytokines are major mediators of inflammatory responses in rheumatoid arthritis. Some of them have been shown to correlate with the disease activity and thus are proposed to be used for monitoring patients. Therefore the effects of a low-dose therapy with methotrexate on serum concentrations of interleukin-6 (IL-6) and tumour-necrosis-factor-alpha (TNF-α) were examined in eight patients with seropositive rheumatoid arthritis. Serum levels of IL-6 and TNF-α were significantly elevated in patients compared to healthy controls. Before the onset of MTX treatment IL-6 concentrations were correlated to the c-reactive protein ( P < 0·05) but the correlation was abolished after treatment. For TNF-α no correlations neither before nor after treatment were observed. Both cytokines remained substantially elevated after MTX treatment despite a clear reduction in disease activity. Thus we suggest that one of the effects of MTX might be the inhibition of some of the actions of IL-6 and TNF-α. 相似文献
67.
Summary Among 38 human hybridoma-derived monoclonal rheumatoid factors (RFs) generated from patients with either rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE), two groups of RFs can be identified. Monospecific RFs were derived primarily from patients with RA and are characterized by a binding specificity for IgG3 and/or IgG4. Polyreactive RFs were derived largely from patients with SLE and show a broader pattern of reactivity to all four isotypes of IgG. Neither population of RFs was exclusive to either disease. The binding specificities identified appear to be different from the RFs isolated from patients with mixed cryoglobulinemia and may reflect a different antigen selection mechanism. 相似文献
68.
Piero Volpi Luca Marinoni Corrado Bait Marco Galli Matteo Denti 《Knee surgery, sports traumatology, arthroscopy》2007,15(8):1028-1034
Lateral unicompartmental knee arthroplasty (UKA) is a valid alternative treatment in the event of arthritis confined to the
lateral compartment. This paper examines its indications, technique and short to medium-term results. A total of 159 Miller–Galante
cemented UKA prostheses (Zimmer, Warsaw, Indiana) were implanted consecutively (131 medial and 28 lateral) by the same surgeon.
This study investigates 28 lateral UKAs in 27 patients. Twenty-five implants in 24 patients (including a subject operated
bilaterally) were followed up for 12–60 months. Three patients were discarded on account of to short a follow-up period. The
Hospital for Special Surgery (HSS) knee score was used to compare the pre- and post-operative results of the lateral UKA patients.
The HSS score improved from a pre-op mean of 59.92 (range 48–68) to 88.04 (range 71–95) at the last follow-up. There was a
positive increase in the pain, function and ROM components of the score. The lateral UKA prosthesis can be regarded as a sound
alternative to total knee replacement. Correct patient selection on the basis of optimum surgical indications, however, is
essential.
No benefits of funds were received in support of the study. 相似文献
69.
全膝置换术治疗膝关节创伤性关节炎 总被引:5,自引:4,他引:1
目的探讨全膝置换术(TKA)在膝关节创伤性关节炎治疗中的特点。方法对8例膝关节严重创伤后形成的骨性关节炎施行了TKA手术,术中采用植骨、加装金属垫片的方法修复塌陷的胫骨平台,对内、外翻不稳的膝关节选择了CCK假体代偿由侧副韧带损伤引起的不完全功能缺失,严重者甚至使用旋转型铰链膝,其他还有通过后方的软组织松解等技术来增加关节活动度。结果采用HSS膝关节评分系统,8例由术前的平均42分上升至术后的平均88分(P<0.05),关节活动度由术前的平均76°升至术后的平均106°(P<0.05)。所有患者随访至少1年以上,平均2.1年,随访结束时膝关节评分平均82分(P<0.05),关节活动度平均93°(P<0.05)。结论根据膝关节创伤性关节炎的损伤特点因人而异地选择合适的TKA手术方案可以获得满意的结果,术中注意防止因骨折畸形愈合所导致的技术上的失误。 相似文献
70.
Debbie Ehrmann Feldman Mirella de Civita Patricia L. Dobkin Pete Malleson Garbis Meshefedjian CiarÁn M. Duffy 《Arthritis care & research》2007,57(2):226-233