全文获取类型
收费全文 | 135723篇 |
免费 | 9880篇 |
国内免费 | 2425篇 |
专业分类
耳鼻咽喉 | 1073篇 |
儿科学 | 2831篇 |
妇产科学 | 1642篇 |
基础医学 | 5820篇 |
口腔科学 | 5288篇 |
临床医学 | 13891篇 |
内科学 | 14906篇 |
皮肤病学 | 2168篇 |
神经病学 | 7628篇 |
特种医学 | 2960篇 |
外国民族医学 | 21篇 |
外科学 | 12090篇 |
综合类 | 26525篇 |
现状与发展 | 8篇 |
一般理论 | 6篇 |
预防医学 | 10837篇 |
眼科学 | 1786篇 |
药学 | 16840篇 |
308篇 | |
中国医学 | 13407篇 |
肿瘤学 | 7993篇 |
出版年
2024年 | 458篇 |
2023年 | 2224篇 |
2022年 | 4256篇 |
2021年 | 5697篇 |
2020年 | 5897篇 |
2019年 | 4666篇 |
2018年 | 4357篇 |
2017年 | 4843篇 |
2016年 | 5391篇 |
2015年 | 5132篇 |
2014年 | 11576篇 |
2013年 | 12982篇 |
2012年 | 10385篇 |
2011年 | 10406篇 |
2010年 | 8290篇 |
2009年 | 6642篇 |
2008年 | 5868篇 |
2007年 | 5914篇 |
2006年 | 5105篇 |
2005年 | 4168篇 |
2004年 | 3411篇 |
2003年 | 2924篇 |
2002年 | 2403篇 |
2001年 | 1976篇 |
2000年 | 1708篇 |
1999年 | 1317篇 |
1998年 | 1071篇 |
1997年 | 964篇 |
1996年 | 790篇 |
1995年 | 706篇 |
1994年 | 659篇 |
1993年 | 554篇 |
1992年 | 434篇 |
1991年 | 399篇 |
1990年 | 301篇 |
1989年 | 321篇 |
1988年 | 277篇 |
1987年 | 274篇 |
1986年 | 253篇 |
1985年 | 393篇 |
1984年 | 417篇 |
1983年 | 323篇 |
1982年 | 379篇 |
1981年 | 315篇 |
1980年 | 269篇 |
1979年 | 258篇 |
1978年 | 163篇 |
1977年 | 123篇 |
1976年 | 120篇 |
1975年 | 95篇 |
排序方式: 共有10000条查询结果,搜索用时 19 毫秒
51.
HER2-positive breast cancer is an aggressive subtype identified in the 1980s. The development of therapies targeting the HER2 has improved outcomes. The current standard of care, established in 2012 is dual blockade with trastuzumab + pertuzumab as first-line followed by TDM-1 as second-line. Several suboptimal choices are available in third-line or more. In 2019 the presentation of several trials evaluating new drugs and regimens in third-line has re-opened questions about sequencing, treatment of triple positive disease and treatment choice after exposure to TDM-1. These include tucatinib, neratinib and trastuzumab-deruxtecan. Other agents – including other antibody drug conjugates and bispecific antibodies as well as combinations - will lead to further changes in coming years. Additionally, should the numerous putative biomarkers thus identified ever come into use at the clinic, choice of treatment and response evaluation may be substantially changed. 相似文献
52.
《Actas urologicas espa?olas》2020,44(5):281-288
Male infertility accounts for 50% of the causes of infertile couples, being more than 30% of unknown etiology. In these cases, empiric treatment can be an option prior to the application of assisted reproduction techniques. Empiric treatment can be categorized as hormonal, such as gonadotropins, antiestrogens and aromatase inhibitors, and antioxidant, with vitamins, trace elements and carnitine, among others. Although scientifically acceptable evidence is limited due to the absence of large randomized and controlled clinical trials, recent systematic reviews and meta-analyses show that treatment with gonadotropins, antiestrogens and antioxidants increases pregnancy and live birth rates and improves seminal parameters. Empiric medical treatment for idiopathic infertility can be considered in specific cases in order to improve semen quality and spontaneous fertility. 相似文献
53.
《The Journal of hand surgery》2020,45(2):153.e1-153.e5
54.
55.
56.
目的 解析真实世界中乳腺恶性肿瘤患者的人群特征、诊断特征、中西医用药特征,为乳腺癌的临床防治提供参考。方法 采集2002年2月至2015年5月全国60家三级甲等医 院信息系统(Hospital Information System,HIS)中,出院诊断为“乳腺癌”的患者用药信息,采用SAS9.3统计软件,对人口学信息、诊断信息、医嘱用药信息等进行描述性分析。结果 39798例乳腺癌患者,平均年龄(50.93者,平均年龄)岁;多以门诊入院,入院病情以“一般”为主;合并疾病主要为高血压,骨肿瘤,联用西药以抑制肿瘤细胞增殖、治疗并发症、缓解放化疗不良反应为主;中医辨证以痰瘀互结证,气阴两虚证,肝气淤滞证,脾气亏虚证型最为常见,临床清热解毒剂、益气扶正剂,活血化瘀剂应用较多。结论 乳腺癌中西医结合治疗,联用药物广泛,临床治疗基本符合临床指南。 相似文献
57.
《Journal of endodontics》2020,46(10):1371-1386.e8
IntroductionThis study aimed to summarize data on apical periodontitis (AP) and nonsurgical root canal treatment (NSRCT) prevalence and risk factors related to age, gender, and quality of restorative and endodontic treatment in the general population from cross-sectional studies published between 2012 and 2020.MethodsAn electronic search was performed in the following databases: Web of Science, Scopus, and PubMed. The conducted literature search covered studies published between 2012 and 2020, without restrictions on language. The STROBE and NOS tools were used for quality assessment of the included studies.ResultsSixteen articles were included in the review. In total, 200,041 teeth were examined. On average, 6.3% of teeth had AP, and 7.4% had NSRCT. Forty-one percent of RCT teeth had AP, and 3.5% of untreated teeth had AP. Female patients were less prone to AP in endodontically treated teeth only, compared with male patients (P < .001). Variable stratification of age subgroups among included studies prevented us from conducting a meta-analysis. An increase in AP frequency was found in teeth with inadequate restorative and endodontic treatment (P < .001 and P < .001, respectively). Because of high heterogeneity, these results should be taken with caution.ConclusionsThere is an increased AP prevalence in the adult general population compared with data from 2012 (6.3% versus 5.4%) in both endodontically treated (41.3% versus 35.9%) and untreated teeth (3.5% versus 2.1%). In addition, AP developed less frequently in female patients with endodontically treated teeth and in teeth with inadequate compared with adequate restorative and endodontic treatment. 相似文献
58.
目的:分析糖尿病视网膜病变合并黄斑水肿联合采用激光与复方血栓通胶囊治疗的临床疗效。方法:选取我院2017年1月—2019年1月收治的200例糖尿病视网膜病变合并黄斑水肿患者为研究对象,随机分为两组。对照组单独行激光治疗,观察组于对照组基础上联合复方血栓通胶囊治疗,对比两组临床疗效、治疗前后IL-6(白介素-6)、VEGF(血管内皮生长因子)、NOS(血清一氧化氮合成酶)水平变化情况。结果:对照组总有效率(68.00%,68/100)较观察组总有效率(98.00%,98/100)更高(P<0.05);与对照组对比,观察组治疗后NOS水平更高,IL-6、VEGF水平更低(P<0.05)。结论:糖尿病视网膜病变合并黄斑水肿联合采用激光与复方血栓通胶囊治疗的临床疗效显著,值得推广。 相似文献
59.
60.
《中国现代医生》2020,58(20):178-180+184
目的 探讨临床护理路径用于ICU重症颅脑损伤患者护理中的价值。方法 选择2017年11月~2018年10月进行ICU重症颅脑损伤治疗的患者100例作为对象,随机数字表法分为对照组(n=50)和观察组(n=50)。对照组给予常规护理,观察组在其基础上应用临床护理路径,15 d护理后比较患者依从性情况、对患者护理前后心理状态进行评分,对不良并发症产生情况进行比较。结果 观察组康复锻炼依从、按时用药依从及饮食依从高于对照组(P0.05)。护理前两组SDS与SAS评分比较差异无统计学意义(P0.05),护理后,观察组SDS与SAS评分低于对照组(P0.05)。观察组出现压疮、泌尿感染、以及发热的发生率显著低于对照组(P0.05)。结论 将临床护理路径用于ICU重症颅脑损伤患者的护理中,提高了患者的护理依从性,减少了不良情绪以及不良并发症的产生,有助于患者整体治疗,值得推广应用。 相似文献