全文获取类型
收费全文 | 70082篇 |
免费 | 4573篇 |
国内免费 | 1160篇 |
专业分类
耳鼻咽喉 | 455篇 |
儿科学 | 1468篇 |
妇产科学 | 704篇 |
基础医学 | 3634篇 |
口腔科学 | 1122篇 |
临床医学 | 7424篇 |
内科学 | 6534篇 |
皮肤病学 | 928篇 |
神经病学 | 3798篇 |
特种医学 | 1478篇 |
外国民族医学 | 5篇 |
外科学 | 4404篇 |
综合类 | 14004篇 |
现状与发展 | 3篇 |
一般理论 | 4篇 |
预防医学 | 6979篇 |
眼科学 | 609篇 |
药学 | 12618篇 |
179篇 | |
中国医学 | 6045篇 |
肿瘤学 | 3420篇 |
出版年
2024年 | 174篇 |
2023年 | 1071篇 |
2022年 | 2122篇 |
2021年 | 2815篇 |
2020年 | 2800篇 |
2019年 | 2381篇 |
2018年 | 2222篇 |
2017年 | 2532篇 |
2016年 | 2888篇 |
2015年 | 2785篇 |
2014年 | 7021篇 |
2013年 | 6711篇 |
2012年 | 5762篇 |
2011年 | 5477篇 |
2010年 | 4059篇 |
2009年 | 3118篇 |
2008年 | 2879篇 |
2007年 | 2679篇 |
2006年 | 2211篇 |
2005年 | 1737篇 |
2004年 | 1388篇 |
2003年 | 1213篇 |
2002年 | 938篇 |
2001年 | 793篇 |
2000年 | 708篇 |
1999年 | 545篇 |
1998年 | 498篇 |
1997年 | 457篇 |
1996年 | 374篇 |
1995年 | 335篇 |
1994年 | 332篇 |
1993年 | 282篇 |
1992年 | 265篇 |
1991年 | 260篇 |
1990年 | 235篇 |
1989年 | 234篇 |
1988年 | 222篇 |
1987年 | 227篇 |
1986年 | 211篇 |
1985年 | 320篇 |
1984年 | 406篇 |
1983年 | 294篇 |
1982年 | 353篇 |
1981年 | 274篇 |
1980年 | 249篇 |
1979年 | 240篇 |
1978年 | 165篇 |
1977年 | 133篇 |
1976年 | 132篇 |
1975年 | 106篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
121.
对我科1989-1990年中收治的婴儿肝炎综合征63例的临床表现、合并症、治疗等方面进行了分析。笔者认为婴儿肝炎综合征为一组临床症候群。病因诊断有其重要性。腹部B超检查有助于肝炎和胆道闭锁的鉴别,可作为常规检查方法。并认为用肾上腺皮质激素治疗有效。 相似文献
122.
河南省50例并殖吸虫病的流行病学和临床特征 总被引:3,自引:0,他引:3
本文对1987-1995年就诊的50例并殖吸虫病患者进行了分析,发现近年来本病在河南省有逐渐增多的趋势。患者主要集中在豫西山区及丘陵地带。各年龄组中儿童占62%,男性多于女性。 相似文献
123.
Summary UK health policy requires child and adolescent mental health service providers to demonstrate that their services are effective.
The FOCUS project has been developed to improve the availability and accessibility of research evidence and innovation, to
support purchasers in the effective commissioning of services and to help providers base service provision on evidence of
effectiveness and develop methods of evaluation. 相似文献
124.
Clinical Efficacy of New Antiepileptic Drugs in Refractory Partial Epilepsy: Experience in the United States With Three Novel Drugs 总被引:1,自引:1,他引:0
Jacqueline A. French 《Epilepsia》1996,37(S2):S23-S26
Summary: A number of new antiepileptic drugs (AEDs), including topiramate (TPM), felbamate (FBM), and gabapentin (GBP), are approved or believed to be close to approval for marketing in the United States. Key efficacy findings for these AEDs in refractory partial epilepsy were reviewed. Large and significant drug-placebo differences were observed with TPM in two large dose-finding trials conducted in the United States. The minimal effective dose of TPM in the population studied was determined to be approximately 200 mg/day, and doses above 600 mg/day produced good efficacy but little incremental benefit versus the lower dosages for the overall study population. FBM is active in partial epilepsy, although seizure reduction is less marked and drug interactions complicate the findings. GBP is also active in this population, but only the 1,800 mg/day dosage was significantly better than placebo with respect to percent re-sponders. It may be useful to explore higher dosage ranges for both FBM and GBP if they can be well tolerated. 相似文献
125.
3-Methoxytyramine (3-MT) is a minor metabolite of dopamine which is suggested to reflect the turnover and utilization of dopamine. A novel, isocratic HPLC method has been developed which can be used to analyse 3-MT in homogenates of rat brain without the need for additional purification procedures. Furthermore, the coulometric electrochemical detection system is sensitive enough to measure 3 pg of 3-MT (equivalent to 0.6 ng/g tissue wet weight). 3-Methoxytyramine was measured in the striatum and n. accumbens after decapitation and rapid freezing, using 3-methoxy-4-hydroxybenzylamine as the internal standard. The effects of dopaminergic and other drugs on this metabolite were examined using this method. -Methyl-p-tyrosine (200 mg/kg i.v.) produced parallel linear decreases in dopamine and 3-MT in naive rats, but not those pretreated with tranylcypromine (5 mg/kg i.p.). Methamphetamine (0.3–10 mg/kg i.p.) and amphetamine (0.3–10 mg/kg i.p.) both dose-dependently increased 3-MT in naive and tranylcypromine-pretreated rats. In naive animals, 3-MT was not altered by intraperitoneal injection of the dopamine reuptake inhibitors, bupropion (10 mg/kg) and nomifensine (10 mg/kg) or by sibutramine HCl (3 mg/kg), amitriptyline (10 mg/kg), desipramine (10 mg/kg) and zimeldine (10 mg/kg). 3-Methoxy-tyramine was decreased by apomorphine (5 mg/kg i.p.) and also by large doses of the selective D2 antagonist, BRL 34778 (5 mg/kg i.p.) or
-DOPA (50 mg/kg i.p.). The selective D1 antagonist, SCH 23390 (0.1 or 5 mg/kg i.p.) was without effect. In tranylcypromine-pretreated rats, 3-MT was dose-dependently reduced and increased by apomorphine (0.01–5 mg/kg i.p.) and BRL 34778 (0.1–5 mg/kg i.p.), respectively. The drug SCH 23390 (0.1–5 mg/kg i.p.) produced much smaller increases in 3-MT which were probably mediated through the striatonigral pathway. Overall, the data suggest that measurement of 3-MT, after inhibition of monoamine oxidase, is a useful index of the release and utilization of dopamine. However, after substantial and prolonged depletion of dopamine, levels of 3-MT in naive animals are a better index. Also, the formation of 3-MT in naive rats provides a sensitive method for distinguishing between dopamine releasing agents and reuptake inhibitors. 相似文献
126.
The pharmacokinetics and haemodynamic effects of isosorbide dinitrate (ISDN) have been investigated following administration of single doses as a sublingual (SL) spray (2.5 mg), sublingual tablet (5 mg) and peroral tablet (10 mg) in a randomised, placebo-controlled double-blind cross-over trial in 16 healthy volunteers.After the sublingual spray Cmax was higher (39.0 ng·ml-1) and tmax was shorter (3.9 min) than after the sublingual (22.8 ng·ml-1 and 13.8 min) and peroral (16.9 ng·ml-1 and 25.6 min) tablets. The AUC of ISDN did not differ following any of the three formulations (1031; 879; 997 ng·ml-1·min, for the spray, SL tablet and PO-tablet, respectively). Mononitrate metabolites of ISDN (IS-2-MN and IS-5-MN) and total nitrates in plasma increased in proportion to the administered dose. This indicates that the fraction of the dose absorbed was the same for all the formulations but that the extent of first-pass metabolism increased in the order sublingual spray < sublingual tablet < peroral tablet. Thus, compared to the spray, the relative bioavailability of ISDN was 48% and 28% from the sublingual and peroral tablets, respectively.The haemodynamic effects were quantified using the a/b ratio of the finger pulse wave and the systolic blood pressure and heart rate under orthostatic conditions. For the a/b ratio of the finger pulse, the maximal effect was higher (emax=130%) and the time to emax (temax) shorter (16.6 min) after the spray than the sublingual tablet (84.4% and 25.5 min) or peroral tablet (90.2 and 31.3 min). The onset of effect was within 3, 5 and 7.5 min after the spray, sublingual and peroral tablets, respectively. A larger change in the orthostatically-induced decrease in systolic blood pressure and increase in heart rate was obtained following peroral than sublingual administration despite the similar plasma concentrations of ISDN. This probably reflects the larger amount of pharmacodynamically active mononitrate metabolites formed after oral dosing. The integrated effect following administration of 2.5 mg ISDN as spray was similar to that of a sublingual tablet of 5 mg. 相似文献
127.
T Kyrklund 《American journal of industrial medicine》1992,21(1):15-24
The nervous system differs from many other body organs by its central control of vital functions and its low regeneration capacity. Organic solvents have, as a group, been suspected to have neurotoxic effects. Because of their similar physical properties and the fact that in industrial uses, they are often present in various mixtures, organic solvents have also been regarded, unfortunately, to induce common neurotoxic effects. However, it is evident from experimental studies using specified exposure conditions that different organic solvents have very diverse neurotoxic effects and also that the toxic mechanism may differ between acute and chronic exposure. No specific method used to describe a neurotoxic effect or single toxic response can be used for the overall occupational risk assessment of all organic solvents. Each solvent has to be considered as having its own unique toxic effects. 相似文献
128.
129.
原发性腹膜后脂肪肉瘤20例报告 总被引:1,自引:0,他引:1
自1965年5月至1991年7月共收治原发性腹膜后脂肪肉瘤20例,均经手术及病理证实。20例中完全切除者15例,部分切除者4例,活检1例。肿瘤切除合并肾,肠襻等邻近器官切除者达12例。全组的5年,10年生存率分别是57.1%和20.0%,完全切除组的5年10年生存率分别是63.6%和28.6%。20例病人共进行了48次切除手术。首次手术死亡2例。着重讨论了本病的诊断、治疗和突出的临床特点。 相似文献
130.
颈动脉加压注射复方维脑路通合剂治疗脑梗死180例临床分析 总被引:1,自引:0,他引:1
本科自 2 0 0 0年 6月以来 ,采用颈动脉加压注射复方维脑路通合剂治疗脑梗死 180例 ,并与静脉给药组相比较 ,现总结如下。1 资料与方法1.1 临床资料 治疗组 180例 ,男 117例 ,女 6 3例 ,年龄 37岁~ 76岁 ,平均年龄 5 7.2 0岁。均为颈内动脉系统脑梗死。其中大面积脑梗死 4例 ,脑梗死 85例 ,腔隙性脑梗死 91例。大面积脑梗死组 4例 ,其梗死灶涉及 2个脑叶或以上 ,均无意识障碍及脑疝者 ,在发病 10d后即脑水肿高峰期后开始颈动脉加压注射。治疗组病例选择除下列禁忌 :①严重高血压病(血压≥ 2 6 .6 / 16kPa) ;②脑出血、出血性梗死 ;③严… 相似文献