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Objectives
This prospective, observational study evaluated changes in ultrasound measurements of the inferior vena caval index (IVCI), the aorta diameter/IVC diameter index (Ao/IVCD), and the aorta area/IVC area index (Ao/IVCA) during fluid administration in children requiring intravenous fluid administration.Methods
Children who presented to the pediatric emergency department with symptoms of dehydration were enrolled between May 2015 and February 2016. The maximum diameter of the aorta, from inner wall to inner wall, and the long and short axis diameters of IVC were measured using a convex array transducer in the transverse view. Subsequently, we measured the diameter of the IVC at the subxiphoid area during inspiration and expiration in longitudinal view. We calculated IVCI, Ao/IVCD, and Ao/IVCA during administration of 10 ml/kg and 20 ml/kg normal saline boluses.Results
IVCI and Ao/IVCA significantly changed immediately after administration of initial 10 ml/kg of NS. Ao/IVCA showed significant change during the additional administration of 10 ml/kg (total 20 ml/kg) normal saline boluses (1.43, IQR 1.12–1.86 vs. 1.08, IQR 0.87–1.45, p value < 0.001). No significant changes were observed for IVCI and Ao/IVCD. Ao/IVCA was significantly correlated with the volume of fluid administered. The coefficient between initial and administration of the 10 ml/kg normal saline bolus was ? 0.396 (p value = 0.010), and that between the 10 ml/kg and 20 ml/kg normal saline boluses was ? 0.316 (p value = 0.038).Conclusions
Ao/IVCA showed better correlations with the volume of fluid administered than IVCI and Ao/IVCA. Ao/IVCA might be a promising index for assessing the effects of fluid administration. 相似文献Introduction
Previous studies have demonstrated that thymoquinone has protective effects against ischemia reperfusion injury to various organs like lungs, kidneys and liver in different experimental models.Objective
We aimed to determine whether thymoquinone has favorable effects on lung, renal, heart tissues and oxidative stress in abdominal aorta ischemia-reperfusion injury.Methods
Thirty rats were divided into three groups as sham (n=10), control (n=10) and thymoquinone (TQ) treatment group (n=10). Control and TQ-treatment groups underwent abdominal aorta ischemia for 45 minutes followed by a 120-min period of reperfusion. In the TQ-treatment group, thymoquinone was given 5 minutes. before reperfusion at a dose of 20 mg/kg via an intraperitoneal route. Total antioxidant capacity, total oxidative status (TOS), and oxidative stress index (OSI) in blood serum were measured and lung, kidney, and heart tissue histopathology were evaluated with light microscopy.Results
Total oxidative status and oxidative stress index activity in blood samples were statistically higher in the control group compared to the sham and TQ-treatment groups (P<0.001 for TOS and OSI). Control group injury scores were statistically higher compared to sham and TQ-treatment groups (P<0.001 for all comparisons).Conclusion
Thymoquinone administered intraperitoneally was effective in reducing oxidative stress and histopathologic injury in an acute abdominal aorta ischemia-reperfusion rat model. 相似文献Incorporation of [2-14C]ethanolamine into total lipid was linear for 3 h of incubation in both blue and white areas. At 3 h, ethanolamine incorporation into phosphatidyl ethanolamine was significantly less in blue than in white areas.
[1,2-14C]Choline incorporation into total lipid was linear for 3 h of incubation in blue areas but not in white areas. At 30 min, choline incorporation into phosphatidyl choline was significantly less in blue than in white areas; at 1 h choline incorporation into phosphatidyl choline was similar in blue and white areas, while after 3 h of incubation incorporation was significantly greater in blue than in white areas.
With both [2-14C]ethanolamine and [1,2-14C]choline, the percentage distribution of label among individual phospholipids was similar in blue and white areas.
Phospholipid content of blue and white areas was similar.
The results presented demonstrate further focal metabolic differences within the same geographical region of the normal young pig aorta. 相似文献