全文获取类型
| 收费全文 | 224482篇 |
| 免费 | 21104篇 |
| 国内免费 | 11048篇 |
专业分类
| 耳鼻咽喉 | 2620篇 |
| 儿科学 | 6417篇 |
| 妇产科学 | 2210篇 |
| 基础医学 | 36696篇 |
| 口腔科学 | 6648篇 |
| 临床医学 | 17844篇 |
| 内科学 | 31689篇 |
| 皮肤病学 | 5012篇 |
| 神经病学 | 12173篇 |
| 特种医学 | 5158篇 |
| 外国民族医学 | 125篇 |
| 外科学 | 36378篇 |
| 综合类 | 33361篇 |
| 现状与发展 | 56篇 |
| 一般理论 | 4篇 |
| 预防医学 | 5325篇 |
| 眼科学 | 4749篇 |
| 药学 | 15090篇 |
| 41篇 | |
| 中国医学 | 5704篇 |
| 肿瘤学 | 29334篇 |
出版年
| 2024年 | 368篇 |
| 2023年 | 3005篇 |
| 2022年 | 5264篇 |
| 2021年 | 7884篇 |
| 2020年 | 7289篇 |
| 2019年 | 7162篇 |
| 2018年 | 7384篇 |
| 2017年 | 7769篇 |
| 2016年 | 8089篇 |
| 2015年 | 8982篇 |
| 2014年 | 13578篇 |
| 2013年 | 15018篇 |
| 2012年 | 12557篇 |
| 2011年 | 14334篇 |
| 2010年 | 12173篇 |
| 2009年 | 11811篇 |
| 2008年 | 12239篇 |
| 2007年 | 12544篇 |
| 2006年 | 11709篇 |
| 2005年 | 10633篇 |
| 2004年 | 9163篇 |
| 2003年 | 7781篇 |
| 2002年 | 6350篇 |
| 2001年 | 5402篇 |
| 2000年 | 4515篇 |
| 1999年 | 3922篇 |
| 1998年 | 3697篇 |
| 1997年 | 3346篇 |
| 1996年 | 3030篇 |
| 1995年 | 2607篇 |
| 1994年 | 2438篇 |
| 1993年 | 1886篇 |
| 1992年 | 1691篇 |
| 1991年 | 1496篇 |
| 1990年 | 1131篇 |
| 1989年 | 1066篇 |
| 1988年 | 1002篇 |
| 1987年 | 774篇 |
| 1986年 | 713篇 |
| 1985年 | 922篇 |
| 1984年 | 801篇 |
| 1983年 | 542篇 |
| 1982年 | 612篇 |
| 1981年 | 484篇 |
| 1980年 | 419篇 |
| 1979年 | 305篇 |
| 1978年 | 225篇 |
| 1977年 | 177篇 |
| 1976年 | 138篇 |
| 1975年 | 51篇 |
排序方式： 共有10000条查询结果，搜索用时 31 毫秒
111.
《Cancer cell》2021,39(11):1497-1518.e11
- Download : Download high-res image (282KB)
- Download : Download full-size image
112.
Worsening pneumonitis due to a pharmacokinetic drug–drug interaction between everolimus and voriconazole in a renal transplant patient 
下载免费PDF全文
下载免费PDF全文 113.
随着对肿瘤热疗和肿瘤免疫微环境(TIME)的深入研究,近年来热疗对TIME的作用越来越受到学者们的重视。本文就目前国内外研究进展,对热疗与TIME中几类主要免疫细胞和免疫相关细胞因子的影响及作用机制作一综述。全面而透彻的了解热疗对TIME的调控作用,有助于为肿瘤治疗提供新的思路和方法。 相似文献
114.
115.
116.
《Vaccine》2016,34(24):2663-2670
Human metapneumovirus (HMPV) is a major cause of morbidity and mortality from acute lower respiratory tract illness, with most individuals seropositive by age five. Despite the presence of neutralizing antibodies, secondary infections are common and can be severe in young, elderly, and immunocompromised persons. Preclinical vaccine studies for HMPV have suggested a need for a balanced antibody and T cell immune response to enhance protection and avoid lung immunopathology. We infected transgenic mice expressing human HLA-A*0201 with HMPV and used ELISPOT to screen overlapping and predicted epitope peptides. We identified six novel HLA-A2 restricted CD8+ T cell (TCD8) epitopes, with M39–47 (M39) immunodominant. Tetramer staining detected M39-specific TCD8 in lungs and spleen of HMPV-immune mice. Immunization with adjuvant-formulated M39 peptide reduced lung virus titers upon challenge. Finally, we show that TCD8 from HLA-A*0201 positive humans recognize M39 by IFNγ ELISPOT and tetramer staining. These results will facilitate HMPV vaccine development and human studies. 相似文献
117.
《Molecular therapy》2020,28(6):1432-1441
- Download : Download high-res image (155KB)
- Download : Download full-size image
118.
119.
Roberto V.P. Ribeiro Mitesh V. Badiwala Danny Ramzy Laura C. Tumiati Vivek Rao 《The Journal of thoracic and cardiovascular surgery》2019,157(2):615-625.e1
Objective
Hypertonic saline (HTS) has potent immune and vascular effects. We assessed recipient pretreatment with HTS on allograft function in a porcine model of heart transplantation and hypothesized that HTS infusion would limit endothelial and left ventricular (LV) dysfunction following transplantation.Methods
Heart transplants were performed after 6 hours of cold ischemic storage. Recipient pigs were randomized to treatment with or without HTS (7.5% NaCl) before cardiopulmonary bypass (CPB). Using a myograft apparatus, coronary artery endothelial-dependent (Edep) and -independent (Eind) relaxation was assessed. LV performance was determined using pressure-volume loop analysis. Pulmonary interleukin (IL)-2, IL-6, and tumor necrosis factor (TNF)-α expression was measured.Results
Weaning from CPB and LV performance after transplantation were improved in HTS-treated animals. Successful weaning from CPB was greater in the HTS-treated hearts (8 of 8 vs 2 of 8; P < .05). Mean LV functional recovery was improved in the HTS-treated animals, as assessed by preload recruitable stroke work (65 ± 10% vs 27 ± 10%; P < .001) and end-systolic elastance (55 ± 7% vs 37 ± 4%; P < .001). Treatment with HTS resulted in improved Edep (mean maximum elastance [Emax], 56 ± 5% vs 37 ± 7%; P < .001) and Eind (mean Emax%, 77 ± 6% vs 52 ± 4%; P < .001) vasorelaxation compared with control. Pulmonary expression of IL-2, IL-6, and TNF-α increased following transplantation, whereas HTS therapy attenuated IL production (P < .001). Transplantation increased plasma TNF-α levels and LV TNF-α expression, whereas HTS prevented this up-regulation (P < .001).Conclusions
Recipient HTS pretreatment preserves allograft vasomotor and LV function, and HTS therapy limits CPB-induced injury. HTS may be a novel recipient intervention to prevent graft dysfunction. 相似文献120.