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41.
Jennie Ponsford Rochelle Whelan-Goodinson Alex Bahar-Fuchs 《Brain injury : [BI]》2007,21(13):1385-1392
Primary objectives: To establish pre-morbid alcohol and drug use in persons with TBI, relative to controls, investigate how patterns of substance use change over time following TBI and identify factors associated with heavy post-injury substance use.
Methods and procedures: The Alcohol Use Disorders Identification test (AUDIT) and Drug Abuse Screening Test (DAST) was completed by 121 hospital inpatients with TBI, documenting pre-injury alcohol and drug use, and 133 demographically similar controls. Participants with TBI completed these measures and the Hospital Anxiety and Depression Scale (HADS) again 1 and 2 years post-injury and 76 also completed them at 3 years.
Results: Participants with TBI showed similar levels of drug and alcohol use to controls pre-injury, with 31.4% of the TBI group and 29.3% of controls drinking at hazardous levels. Alcohol and drug use declined in the first year post-injury, but increased by 2 years post-injury, with only 21.4% of participants with TBI reporting abstinence from alcohol and 25.4% drinking at hazardous levels. Only 9% showed a drug problem, but 24% had returned to some drug use. Those showing heavy alcohol use post-injury were young, male and heavy drinkers pre-injury. Drug and alcohol use was similar at 3 years post-injury.
Conclusions: More active intervention is needed to reduce alcohol and drug use following TBI. 相似文献
Methods and procedures: The Alcohol Use Disorders Identification test (AUDIT) and Drug Abuse Screening Test (DAST) was completed by 121 hospital inpatients with TBI, documenting pre-injury alcohol and drug use, and 133 demographically similar controls. Participants with TBI completed these measures and the Hospital Anxiety and Depression Scale (HADS) again 1 and 2 years post-injury and 76 also completed them at 3 years.
Results: Participants with TBI showed similar levels of drug and alcohol use to controls pre-injury, with 31.4% of the TBI group and 29.3% of controls drinking at hazardous levels. Alcohol and drug use declined in the first year post-injury, but increased by 2 years post-injury, with only 21.4% of participants with TBI reporting abstinence from alcohol and 25.4% drinking at hazardous levels. Only 9% showed a drug problem, but 24% had returned to some drug use. Those showing heavy alcohol use post-injury were young, male and heavy drinkers pre-injury. Drug and alcohol use was similar at 3 years post-injury.
Conclusions: More active intervention is needed to reduce alcohol and drug use following TBI. 相似文献
42.
We have established a rat model that reflects the course of development of alcohol and opiate addiction. The present study
with d-amphetamine aimed to define general principles in the development of an addiction. Male rats had a continuous free choice
between d-amphetamine solutions (100, 200 and 400 mg/l) and water for 47 weeks. An initial intake of high doses of d-amphetamine during the first weeks of drug choice was followed by an individually stable pattern of drug consumption of moderate
drug doses. During this period of controlled consumption (from week 10 to week 40), the voluntary intake of d-amphetamine depended on individual factors (dominant rats: 0.37 ± 0.02 mg/kg per day, subordinate rats: 0.57 ± 0.05 mg/kg
per day) and environmental variables (group housing: 0.21 ± 0.02 mg/kg per day, single housing: 0.41 ± 0.03 mg/kg per day).
Beginning with week 41, voluntary d-amphetamine consumption progressively increased (1.9 ± 0.2 mg/kg per day in week 47), although the experimental conditions
remained unchanged. Drug intake during a retest (free choice as before) after 6 months of drug deprivation revealed that the
rats had persistently lost their control over drug intake and were no longer able to adjust drug taking to internal and external
conditions. These addicted rats took very high drug doses, even when all d-amphetamine solutions but not water were adulterated with bitter tasting quinine (6.6 ± 0.6 mg/kg per day; age-matched controls:
0.37 ± 0.04 mg/kg per day). Forced intake of d-amphetamine for 47 weeks (7.1 ± 0.3 mg/kg per day) via the drinking fluid caused physical dependence (hyperreactivity during
withdrawal) but did not lead to drug addiction (voluntary intake in the retest with adulteration: 0.42 ± 0.04 mg/kg per day).
Both the temporal development and the prerequisites of psychostimulant addiction were in principle the same as for alcohol
and opiates.
Received: 3 April 1998/Final version: 26 August 1998 相似文献
43.
Herbert J. Weingartner Robert Rawlings David T. George Michael Eckardt 《Psychopharmacology》1998,138(3-4):311-317
This study was designed to examine and contrast cognitive effects (explicit memory and access to semantic knowledge) of the
benzodiazepine Halcion (triazolam) in ten normal volunteers and ten cognitively unimpaired detoxified alcoholics. The two
groups were indistinguishable from one another under placebo conditions on all measures of cognitive functioning. Under Halcion
test conditions (0.375 mg PO), both groups were about equally impaired in their recall of to-be-remembered information. However,
alcoholics, were more likely to recall information that they were not asked to remember (intrusion errors) on all measures
of explicit remembering. Alcoholics also generated relatively uncommon (low frequency) responses from semantic memory, rather
than common, categorically related associations in response to stimuli such as types of vegetables, flowers, and fruit following
the administration of Halcion, but were not different from normal volunteers in the types of responses generated under placebo
conditions. These findings suggest that a drug challenge that simulates many of the effects of acute alcohol administration
induces alcoholics to think and remember differently (qualitatively) from normal volunteers.
Received: 7 July 1997 / Final version: 22 September 1997 相似文献
44.
Reinstatement of alcohol-seeking by priming injections of alcohol and exposure to stress in rats 总被引:10,自引:5,他引:5
A. D. Lê B. Quan W. Juzytch P. J. Fletcher N. Joharchi Y. Shaham 《Psychopharmacology》1998,135(2):169-174
Previous studies using a reinstatement procedure have found that acute reexposure to the self-administered drug and exposure
to footshock stress reinstate heroin and cocaine seeking after prolonged drug-free periods. Here we tested whether these findings
generalize to alcohol-taking behavior. Male rats were initially allowed to consume alcohol in a two-bottle choice procedure
(water versus alcohol) for 30 min/day for 36 days. Rats were then trained for 60 min/day in operant chambers to press a lever
for the drug (0.13 ml of 12% w/v of an alcohol solution) for up to 55 days. After stable drug-taking on a fixed-ratio-3 schedule
of reinforcement was obtained, lever pressing for alcohol was extinguished by terminating drug delivery for 4–9 days. Reinstatement
of drug seeking was then determined after non-contingent priming injections of alcohol (0.24 and 0.48 g/kg; given IP and orally)
or exposure to intermittent footshock stress (5 and 15 min; 0.8 mA). Priming injections of alcohol produced a modest dose-dependent
reinstatement of drug seeking, whereas footshock stress potently reinstated extinguished alcohol seeking. In contrast, similar
parameters of footshock failed to reinstate extinguished sucrose-taking behavior in rats previously trained to lever press
for sucrose pellets. These findings extend previous reports on reinstatement of cocaine and heroin seeking by a footshock
stressor and by priming drug injections. It also appears that the reinstatement procedure provides an appropriate methodology
to study relapse to alcohol-taking behavior in the drug-free state.
Received: 9 April 1997 / Final version: 1 August 1997 相似文献
45.
Aaro Leinonen Topi Siniluoto Markku Päivänsalo Ari Karttunen Matti I. Kairaluoma Ilkka Suramo 《European radiology》1993,3(3):213-218
Nineteen patients with 49 symptomatic non-neoplastic non-parasitic simple hepatic cysts were subjected to ultrasonographically guided percutaneous aspiration and temporary injection of 99% ethanol into the cyst. Small cysts were treated twice, the large ones three times at the same sitting. The volume of alcohol per injection varied from 20 to 100 ml, depending on the size of the cyst. A cure was usually achieved with one ethanol sclerotherapy treatment. Only minor side effects such as transient pain and temperature elevation occurred. Forty-seven of the 49 cysts could be treated adequately, and did not recur during a follow-up period af 12–40 months. The results indicate that aspiration an and ethanol sclerotherapy is the treatment of choice in patients with symptomatic non-neoplastic simple hepatic cysts or polycystic liver disease.
Correspondence to: A. Leinonen 相似文献
46.
The role of the ethanol training dose on the ability of the selective 5-HT1 agonist TFMPP (m-trifluoromethylphenylpiperazine) to produce ethanol-like discriminative stimulus effects was evaluated in three groups of rats trained to discriminate 1.0 g/kg (n=5), 1.5 g/kg (n=6) or 2.0 g/kg (n=7) ethanol (IG) from water using a two-lever procedure with food reinforcement available under a fixed ratio 20 (FR 20) schedule. Ethanol generalization gradients were comparable in the three groups, indicating few potency differences in the ethanol stimulus across training dose. However, the ability of TFMPP (0.1–1.7 mg/kg; IP) to substitute for ethanol was dependent on the training dose. TFMPP resulted in partial substitution in the 1.0 g/kg group, complete substitution for 1.5 g/kg group and no substitution in the 2.0 g/kg ethanol training group. The results indicate a serotonergic component to the discriminative stimulus effects of an intermediate dose of ethanol that is not prominent as the dose of ethanol is raised. These data add further support for the hypothesis that ethanol produces a mixed discriminative cue, the components of which are not uniformly amplified when the dose of ethanol is increased. 相似文献
47.
The effect of 9-tetrahydrocannabinol ( 9-THC) and alcohol, singly and in combination, on divided attention performance was investigated in cannabis users and non-users who were matched for alcohol use. Both cannabis and alcohol produced decrements in central and peripheral signal detections. Drug and alcohol effects were greater for signal presentations in the periphery. Cannabis users were less impaired in peripheral signal detection than non-users while intoxicated by cannabis and/or alcohol. These findings suggest the development of tolerance and cross-tolerance in regular cannabis users and/or the ability to compensate for intoxication effects. 相似文献
48.
Alcohol and the Psychophysiological Detection of Deception 总被引:1,自引:0,他引:1
Psychophysiological detection of deception examinations were conducted on 40 subjects. Of these, 32 were “guilty” of a mock crime and 8 were innocent. Sixteen guilty subjects committed the crime while intoxicated and the remaining 16 committed the crime sober. These two groups of guilty subjects were subdivided such that half of each group was examined with the polygraph while intoxicated and the other half was examined while sober. Two questioning techniques were used in the examination, a Control Question Test and the Guilty Knowledge Test. Measures of skin resistance, heart rate and respiration were recorded. The principal findings were that alcohol intoxication during the crime reduced detectability with detection scores derived from the measurement of skin resistance responses on the Control Question Test and on the Guilty Knowledge Test. The analyses of guilt/innocent classifications, based on the detection scores, showed these classifications to be affected by alcohol intoxication. 相似文献
49.
本文报道了一种实体组织用于DesoxyribonucleicAcid(DNA)分析的Flowcy tometry(FCM) )样品保存新方法 ,即新鲜组织块乙醇直接固定法。所用样品为头颈部肿瘤手术切除的新鲜标本 3 0例 ,每例标本重约 0 5~ 1 g ,均等分为两份 ,1份置 70 %乙醇直接固定 ,室温放置 ,待两年后FCM检测。另一份置生理盐水中立即行流式细胞术DNA分析。两组样品经机械法制成单细胞悬液 ,PI染色后上机检测。结果显示 :从两组样品的DNA直方图分析 ,CV(coefficiencyofvariation)值、GO/G1、S及G2 /M各期比率无显著差异 (P >0 0 5)。我们认为在样品收集短期内难以完成 ,需积累保存 ,或需保存半年以上者 ,且不具备低温冷冻设备的条件下 ,新鲜组织块乙醇直接固定法是优于将组织块先制备成单细胞悬液再行乙醇固定的流式细胞术DNA样品保存方法 相似文献
50.
The intracerebroventricular administration of the 17 amino acid peptide nociceptin/orphanin FQ (N/OFQ), the endogenous ligand of the NOP receptor (previously referred to as ORL-1 or OP4 receptor), reduces voluntary 10% ethanol intake in genetically selected Marchigian Sardinian alcohol-preferring (msP) rats. Studies aimed at the pharmacological characterization of the receptor, which mediates the effect, have shown that the C-terminal 13 amino acid sequence is crucial for activity and that the selective NOP receptor antagonist [Nphe(1)]N/OFQ(1-13)NH(2) blocks the effect of N/OFQ on ethanol drinking. In place conditioning studies, N/OFQ abolishes the conditioned place preference (CPP) induced by ethanol in msP rats, or by morphine in nonselected Wistar rats; these findings suggest that N/OFQ is able to abolish the rewarding properties of ethanol and morphine. Moreover, N/OFQ inhibits reinstatement of alcohol-seeking behavior induced to electric footshock stress, as well as reinstatement of alcohol-seeking behavior induced by ethanol-paired cues. Together, these findings suggest that N/OFQ and its receptor may represent an interesting target for pharmacological treatment of alcohol abuse. 相似文献