Increased risk of renal dysfunction with percutaneous mechanical thrombectomy compared with catheter-directed thrombolysis

Objective

Percutaneous mechanical thrombectomy (PMT) is regularly used in the treatment of both venous and arterial thrombosis. Although there has been no formal report, PMT has been linked to cases of reversible postoperative acute kidney injury (AKI). The purpose of this study is to evaluate the risk of renal dysfunction in patients undergoing PMT vs catheter-directed thrombolysis (CDT) for treatment of an acute thrombus.

Factors influencing collagen-induced autoimmune ear disease

In 1981, the authors described a type II collagen-induced autoimmune ear disease (CIAED) model. The purpose of this study was to gather further evidence that this is a sound animal model to use in evaluating inner ear diseases. The temporal bone lesions of CIAED in Lewis and Wistar rats were characterized by the presence of sensorineural hearing loss with mild atrophy of the organ of Corti and spiral ganglion degeneration, vestibular dysfunction with vacuolar degeneration of the crista ampullaris, otospongiosis-like lesions in the tympanic annules, cochlear vasculitis, and eustachian tube disease. Both cellular and humoral immune responses to type II collagen were demonstrated. The induction of ear lesions depends on many factors. In general, animals immunized with antigens in complete Freund's adjuvant showed relatively more severe lesions than animals immunized with antigens in incomplete Freund's adjuvant, but the duration of the immunization seems to be a more important factor in reproducing severe lesions. The strain and the source of the animals are also important factors in autoimmune inner ear diseases, as is the condition of the host animals. Subclinical or clinical mycoplasma infection in the rat markedly reduced the incidence and severity of lesions in type II collagen-induced arthritis. Many researchers did not consider sialoductal adenovirus, widely present among laboratory rats, a lesion-producing factor in rats. Although many factors influence the induction and severity of CIAED, these animal models provide an excellent new avenue of inner ear research.