全文获取类型
收费全文 | 343636篇 |
免费 | 28937篇 |
国内免费 | 9173篇 |
专业分类
耳鼻咽喉 | 2801篇 |
儿科学 | 5187篇 |
妇产科学 | 4833篇 |
基础医学 | 52287篇 |
口腔科学 | 7354篇 |
临床医学 | 24432篇 |
内科学 | 47523篇 |
皮肤病学 | 5395篇 |
神经病学 | 25935篇 |
特种医学 | 10562篇 |
外国民族医学 | 47篇 |
外科学 | 28692篇 |
综合类 | 44048篇 |
现状与发展 | 42篇 |
一般理论 | 8篇 |
预防医学 | 23900篇 |
眼科学 | 4104篇 |
药学 | 47122篇 |
88篇 | |
中国医学 | 18992篇 |
肿瘤学 | 28394篇 |
出版年
2024年 | 838篇 |
2023年 | 5129篇 |
2022年 | 11468篇 |
2021年 | 14377篇 |
2020年 | 11737篇 |
2019年 | 13710篇 |
2018年 | 13432篇 |
2017年 | 13136篇 |
2016年 | 12389篇 |
2015年 | 13054篇 |
2014年 | 17506篇 |
2013年 | 21454篇 |
2012年 | 17942篇 |
2011年 | 21194篇 |
2010年 | 15698篇 |
2009年 | 16374篇 |
2008年 | 16749篇 |
2007年 | 17489篇 |
2006年 | 16048篇 |
2005年 | 14103篇 |
2004年 | 11483篇 |
2003年 | 10293篇 |
2002年 | 8087篇 |
2001年 | 7111篇 |
2000年 | 6046篇 |
1999年 | 5175篇 |
1998年 | 4409篇 |
1997年 | 4322篇 |
1996年 | 3936篇 |
1995年 | 3555篇 |
1994年 | 3336篇 |
1993年 | 2854篇 |
1992年 | 2518篇 |
1991年 | 2293篇 |
1990年 | 1976篇 |
1989年 | 1616篇 |
1988年 | 1535篇 |
1987年 | 1417篇 |
1986年 | 1443篇 |
1985年 | 2311篇 |
1984年 | 2164篇 |
1983年 | 1553篇 |
1982年 | 1617篇 |
1981年 | 1353篇 |
1980年 | 1238篇 |
1979年 | 968篇 |
1978年 | 642篇 |
1977年 | 560篇 |
1976年 | 553篇 |
1975年 | 393篇 |
排序方式: 共有10000条查询结果,搜索用时 17 毫秒
101.
102.
《Mayo Clinic proceedings. Mayo Clinic》2019,94(7):1321-1329
Immune checkpoint inhibitors are molecules that increase the endogenous immune response against tumors. They have revolutionized the field of oncology. Since their initial approval for the treatment of advanced melanoma, their use has expanded to the treatment of several other advanced cancers. Unfortunately, immune checkpoint inhibitors have also been associated with the emergence of a new subset of autoimmune-like toxicities, known as immune-related adverse events. These toxicities differ depending on the agent, malignancy, and individual susceptibilities. Although the skin and colon are most commonly involved, any organ may be affected, including the liver, lungs, kidneys, and heart. Most of these toxicities are diagnosed by excluding other secondary infectious or inflammatory causes. Corticosteroids are commonly used for treatment of moderate and severe immune-related adverse events, although additional immunosuppressive therapy may occasionally be required. The occurrence of immune-related toxicities may require discontinuation of immunotherapy, depending on the specific toxicity and its severity. In this article, we provide a focused review to familiarize practicing clinicians with this important topic given that the use of immune checkpoint inhibitors continues to increase. 相似文献
103.
Khaled Adil Marija Popovic Fabio L. Cury Sergio L. Faria Marie Duclos Luis Souhami 《Practical radiation oncology》2019,9(1):24-28
Purpose
This study aimed to investigate 3 planning target volume (PTV) margin expansions and determine the most appropriate volume to be used in bladder preservation therapy when using daily cone beam computed tomography (CBCT). We aimed to establish whether a smaller PTV expansion is feasible without risking geographical miss.Methods and materials
The study included patients with bladder cancer who were treated with a hypofractionated course of radiation therapy delivered with intensity modulated radiation therapy. The clinical target volume (CTV) was the whole empty bladder, and the PTV consisted of a 1.5-cm margin around the bladder (PTV1.5 cm). Patients underwent daily CBCT imaging before treatment to assess the bladder volume and ensure accurate positioning. We investigated 2 additional smaller PTV margin expansions to determine the most appropriate volume to be used with CBCT as a daily image guided radiation therapy modality. These margins were created retrospectively on every CBCT. The first additional volume was a uniform PTV margin of the surrounding 1 cm (PTV1 cm). When considering that the majority of the internal bladder movement was due to the variation in filling that occurs in the superior and anterior directions, a second volume of an anisotropic PTV margin with a 1.5-cm superior/anterior and 1 cm in other directions (PTV1/1.5 cm) was created. We recorded the frequency and measured the volume of bladder falling out of each PTV based on the daily CBCT.Results
For the purpose of this study, we considered an arbitrary 5 cm3 of CTV falling out of the designated PTV as a clinically significant volumetric miss. The frequency of such a miss when applying the uniform PTV1 cm was 1%. However, when applying the uniform PTV1.5 cm and anisotropic PTV1/1.5 cm margins, the frequency was 0.5% and 0.5%, respectively.Conclusions
The anisotropic PTV expansion of 1.5 cm superiorly and anteriorly and 1 cm in all other directions around the bladder (CTV) provides a safe PTV approach when daily CBCT imaging is used to localize an empty bladder. 相似文献104.
105.
目的探讨对先天性耳甲腔型小耳畸形患者行全扩张法全耳再造术后,利用残耳皮瓣改善再造耳颅耳沟的效果。方法回顾分析 2012 年 1 月—2017 年 1 月收治的 150 例先天性耳甲腔型小耳畸形患者。其中男 92 例,女 58 例;年龄 6.5~35.0 岁,平均 11.1 岁。采用一期扩张器埋置、二期全扩张法全耳再造术后发现上部颅耳沟浅显;于 6~12 个月后行三期再造耳修整。将残耳垂通过“Z”字改型转移以再造耳垂。在残耳上部作蒂在轮屏切迹的残耳上部皮瓣,弧形切开松解并加深上部颅耳沟,将上部残耳皮瓣向颅耳沟创面旋转推进缝合以覆盖创面;将带皮下组织蒂的残耳软骨组织瓣插入支架底部形成的腔隙内,并缝合固定,以增加支架的高度;耳甲腔区其余残耳皮瓣用以覆盖耳甲腔创面。结果术后拆线时 1 例患儿皮瓣远端出现直径约 0.5 cm 的表皮水疱,经换药 2 周后愈合;其余患者皮瓣成活良好。患者均获随访,随访时间 6~12 个月,平均 9.6 个月。再造耳上部颅耳沟均明显加深,再造耳支架高度不同程度增加,双耳对称性佳,耳甲腔无明显挛缩变小,再造耳外观满意。再造耳上部表面毛发明显减少,耳周发际线上移。结论采用耳甲腔型小耳畸形的残耳皮瓣及残耳软骨瓣转移,不仅可加深颅耳沟,而且可增加上部支架的高度,术后颅耳沟变形较轻,再造耳与正常耳廓的对称性更佳。 相似文献
106.
目的 收集藿香正气汤的主要活性成分,通过分子对接及网络药理学探讨其防控新型冠状病毒肺炎(COVID-19)的有效成分及治疗机制。方法 通过基于配体-蛋白质相互作用的计算方法,以瑞德西韦为对照,探索藿香正气汤潜在治疗COVID-19的成分,并选出对接较好成分进行药理学机制预测,初探其药理学机制。结果 本研究筛选出5种与新冠病毒3CLpro结合能力强于瑞德西韦的小分子成分。网络药理学初步预测抗病毒途径可能是通过PI3K-Akt 信号通路影响病毒复制。结论 成分C1-C5与3CLpro结合良好,推测其可能是潜在的3CLpro的抑制剂,为抗病毒天然药物的开发提供了理论依据。 相似文献
107.
108.
目的:讨论普通变异型免疫缺陷病(common variable immunodeficiency disease,CVID)的发病机制、临床表现及治疗方法。方法:报道1例普通变异型免疫缺陷病合并肝硬化患者并复习相关文献。结果:普通变异型免疫缺陷病是临床少见病,易误诊,病因不清,临床表现复杂,部分患者病程中可出现肝功能异常,甚至并发肝硬化。结论:临床反复感染的患者应考虑CVID的可能,须进一步作血浆免疫球蛋白的检测确诊。对已经确诊患者定期补充静脉丙种球蛋白,同时还应定期检查肝功能。 相似文献
109.
110.
《Saudi Pharmaceutical Journal》2020,28(7):844-849
Epilepsy is a common neurologic disorder, which is efficiently treated with carbamazepine and valproic acid. Moreover, Saudi Ministry of Health implemented a new E-system for Poison Control Centers called Awtar to enhance technology utilization in ensuring patients’ satisfaction and to improve treatment outcomes. Therefore, we conducted this study to assess appropriateness of indication of requests and therapeutic levels of carbamazepine and valproic acid in Tabuk area, North West Saudi Arabia. This is a retrospective observational study conducted in Poison Control & Forensic Chemistry Center, Tabuk, Saudi Arabia. Patients’ data were obtained for years 2018 and 2019. The blood levels of carbamazepine and valproic acid were measured by Therapeutic Drug Monitoring (TDM) Unit. We selected patients treated with either valproic acid or carbamazepine alone without any history of drug allergy. Data of 264 patients were extracted from Awtar E-system. Serum carbamazepine levels were within therapeutic range in 114 patients (75.50%), above-therapeutic range in 13 patients (8.61%) and sub-therapeutic levels in 24 patients (15.89%). Regarding serum valproic acid, it is within therapeutic range in 62 patients (54.87%), above-therapeutic range in 11 patients (9.73%) and sub-therapeutic levels in 40 patients (35.40%). In conclusion, this study gives information about partial appropriateness of usage of carbamazepine and low level of appropriateness of valproic acid. However, more efforts are needed to improve results of appropriateness of indication of antiepileptic drugs. 相似文献