平顶双焦点镜治疗高AC／A型非屈光性调节性内斜视

用平顶双焦点镜对８２例高ＡＣ／Ａ型非屈光性调节性内斜视进行治疗，可矫正患儿看近的内斜视。戴镜一段时间后，大部分患儿的高ＡＣ／Ａ比率得到控制，并且逐渐减少，视功能得到改善。我们认为：平顶双焦点镜治疗该型内斜有效，早期配镜可避免或减少弱视、单眼抑制及异常视网膜对应的发生。     

ERK信号传导通路调控乙醛刺激的肝星状细胞Na+/Ca2+泵mRNA表达的研究

目的 :探讨Erk信号传导通路调控乙醛刺激的肝星状细胞 (HSC)Na /Ca2 泵mRNA表达的影响。方法 :用链霉蛋白酶和胶原酶原位灌流 ,Metrizamide密度梯度离心分离大鼠肝星状细胞 ,采用RT PCR测定PD980 5 9阻断乙醛激活的肝星状细胞Erk活性后Na /Ca2 泵mRNA表达。结果 :乙醛刺激后 ,HSC后明显促进Na /Ca2 泵mRNA表达 (P<0 0 1) ,不同剂量PD980 5 9对肝星状细胞Na /Ca2 泵mRNA表达的影响无统计学意义。结论 :Erk信号传导通路可能对乙醛刺激的肝星状细胞激活状态的启动无明显影响     

异丙酚促进睡眠剥夺恢复

背景：睡眠和全麻在神经生理上某些相似性，使全麻恢复睡眠剥夺后的睡眠平衡成为可能。然而，麻醉对睡眠平衡的作用尚不清楚。为了证实全麻可促使睡眠剥夺后的恢复，作者让大鼠持续24h不能睡眠后，给以6h的睡眠或异丙酚麻醉，并比较了两种不同处理后睡眠的特点。     

铁调节蛋白2基因多态性与阿尔茨海默病及血管性痴呆的相关分析

Objective To evaluate the association of 2616c/T polymorphism in iron regulatory protein 2(IRP2)gene with Alzheimer disease(AD)and Vascular dementia(VD).Methods In this study,281 patients with AD,60 with VD,and 285 normal aged were recruited.The 2616C/T polymorphism in IRP2 gene was analyzed by using polymerase chain reaction-restriction fragment length polymorphism.And the cognitive function was assessed with the Mini-Mental State Examination(MMSE).Results (1)No significant difieFences were demonstrated in IRP2 genotype or allele frequencies between AD patients and controls(χ2=2.46,P=0.292;χ2=2.17,P=0.141 respectively).However,when AD patients were stratified by disease severity.the frequency of T allele carriers in the moderate to severe AD patients was 78.0%,significantly higher than that in controls(69.8%;χ2=4.106,P＜0.05).Logistic regression analysis demonstrated that the age-,sex-and ApoE-adiusted OR of modcrate to severe AD patient with T allele was 1.62(95% CI=1.03-2.54).The frequency of T allele carriers or T allele in VD patients was higher than that of controls,but the difference was not statistically significant(P＞0.05).(2)The frequency of tit genotype or T allele in the moderate to severe AD patients was significantly higher than that in mild AD patients(25.8%vs.12.5%,χ2=5.477,P＜0.05;51.9%vs.40.3%,χ2=5.803,P＜0.05 respectively).(3)MMSE scores of the AD patients with TT genotype was significantly lower than ones with CC or CT genotype(P=0.028;P=0.014 respectively).Conclusion The 2616C/T polymorphism in the IRP2 gene is possibly associated with moderate to severe AD.but not associated with VD.And the TT genotype may be a risk factor for cognitive impairment of patients with AD in Chinese Han.     

脓毒症内分泌调节机制的研究进展

内分泌系统是机体应激时十分重要的调控系统之一,创伤、感染等外部打击以及体内免疫、炎症甚至心理等内在因素改变都可以引起神经内分泌系统的变化。内分泌系统可进一步广泛的参与机体代谢、免疫、炎症、凝血等众多方面的调节过程,在脓毒症的发生发展中具有重要作用。一、脓毒症时内分泌激素水平发生改变内分泌系统是机体重要的防御系统之一。机体可通过激活下丘脑 垂体 肾上腺(HPA)轴,加速能量供给,保护心、脑、肺等重要器官,降低过度炎症反应以及抑制生殖等非必要的能量消耗,以确保机体承受打击所造成的损害。首先,HPA轴在脓毒症早期活…     

MicroRNA在癌症领域受到广泛的重视

十年前,有一种遗传分子仅仅能在雷达屏幕上看到,然而,到了现在它已经在癌症生物学领域扮演了重要角色。之所以把它命名为m icroRNA,是因为它其实就是一种短链RNA,有人报导它与致癌蛋白共同作用去加速癌症的生长。还有人发现某些m icroRNA分子可以抑制一种维持细胞复制处于静止的复合物。南加利福尼亚哈蒙德大学的ScottM.Hammond认为,这些发现说明m icroRNA在调节基因的激活上扮演了重要角色。在第三个报导中,科学家们阐述了一些基因激活的模式,这些基因编码了m icroRNA的信号,也许有一天医生能用这些信号来确定肿瘤的来源。Bethesda…     

害人害己的“摩擦癖”

子默眉清目秀，神态温和，乍看让人感觉是个很听话的学生。可就是这么一个还带几分羞涩的大男孩，却屡次被人视为“流氓”而扭送公安局——