Treatment of singultus following craniocerebral injury★ Intranasal cavity drip infusion versus intramuscular injection of aminazine

BACKGROUND: Craniocerebral injury always accompanies with singultus, while frequent singultus may cause increased intracranial pressure. Simultaneously, respiratory alkalosis and cerebral hypoxia induced by respiratory disorder may aggravate craniocerebral injury. OBJECTIVE: To observe the therapeutic effects of intranasal cavity drip infusion of aminazine and intramuscular injection on singultus following craniocerebral injury. DESIGN: Contrast observation. SETTING: Department of Neurosurgery, Xi'an Aerospace General Hospital. PARTICIPANTS: A total of 102 patients with singultus following craniocerebral injury were selected from the Department of Neurosurgery, Xi'an Aerospace General Hospital from June 2001 to June 2006. Patients with craniocerebral injury were diagnosed with CT examination and randomly divided into nasal cavity medication group (n =62) and intramuscular injection group (n =40). There were 44 males and 18 females in the nasal cavity medication group and their mean age was (33±4) years; while, there were 26 males and 14 females in the intramuscular injection group and their mean age was (29±4) years. All patients and their relatives provided the confirmed consent. METHODS: Patients in the nasal cavity medication group were slowly dripped aminazine solution into bilateral nasal cavity with the dosage of 12.5 mg (0.5 mL). Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was stopped if symptoms were also observed after the fifth medication. In addition, patients in the intramuscular injection group received intramuscular injection of 50 mg aminazine. Patients who had no obvious effect or had mild improvement received the treatment once every 6 hours. The treatment was changed if symptoms were also observed after the fifth medication. MAIN OUTCOME MEASURES: Therapeutic effects of different medications in the two groups. RESULTS: All 102 patients were involved in the final analysis. Effective rate in the nasal cavity medication group was higher than that in the intramuscular injection group, and there was significant difference (χ2= 11.882, P < 0.01). At 6 hours after onset of singultus, effective rate in the nasal cavity medication group was higher than that in the intramuscular injection group, and there was significant difference (χ2 =8.188, P < 0.01). CONCLUSION: Therapeutic effects of intranasal cavity drip infusion of aminazine on singultus following craniocerebral injury are superior to those of intramuscular injection.     

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我们于2006年7月～2007年2月对147例尖锐湿疣(CA)患者采用微波手术治疗后,局部注射干扰素进行治疗,并配合适当的护理措施,取得了满意的临床治疗效果,并与肌肉注射干扰素作对比观察,现报道如下。     

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干扰素肌肉注射治疗疱疹性咽炎疗效观察

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术中经食管超声心动图在血管外科中的应用

干细胞移植治疗下肢血管疾病是1998年人类干细胞研究不断深入的结果,多能干细胞的分化潜能为组织工程修复治疗提供了依据。干细胞移植在下肢血管病变中的应用虽然只有很短的时间,却有良好的前景。现将第5届国际血管外科暨第1届国际糖尿病血管疾病会议中有关干细胞移植的进展介绍给大家。     

门诊肌肉注射部位感染原因分析及对策

本文对引起注射部位感染原因进行了分析 ,通过采取相应对策为避免今后院内感染的发生提供了帮助。     

强痛定肌肉注射过敏一例

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