L-carnitine alleviates sciatic nerve crush injury in rats：functional and electron microscopy assessments

Several studies have demonstrated that L-carnitine exhibits neuroprotective effects on injured sciatic nerve of rats with diabetes mellitus. It is hypothesized that L-carnitine exhibits neuro-protective effects on injured sciatic nerve of rats. Rat sciatic nerve was crush injured by a forceps and exhibited degenerative changes. After intragastric administration of 50 and 100 mg/kg L-carnitine for 30 days, axon area, myelin sheath area, axon diameter, myelin sheath diameter, and numerical density of the myelinated axons of injured sciatic nerve were similar to normal, and the function of injured sciatic nerve also improved signiifcantly. These ifndings suggest that L-carnitine exhibits neuroprotective effects on sciatic nerve crush injury in rats.     

Targeted thrombolysis strategies for neuroprotective effect

Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field.     

In the presence of danger：the extracellular matrix defensive response to central nervous system injury

Glial cells in the central nervous system （CNS） contribute to formation of the extracellular matrix, which provides adhesive sites, signaling molecules, and a diffusion barrier to enhance efficient on and axon potential propagation. In the normal adult CNS, the extracellular matrix （ECM） is relatively stable except in selected regions characterized by dynamic remodeling. However, after trauma such as a spinal cord injury or cortical contusion, the lesion epicenter becomes a focus of acute neuroinflammation. The activation of the surrounding glial cells leads to a dramatic change in the composition of the ECM at the edges of the lesion, creating a perilesion environment dominated by growth inhibitory molecules and restoration of the peripheral/ central nervous system border. An advantage of this response is to limit the invasion of damaging cells and diffusion of toxic molecules into the spared tissue regions, but this occurs at the cost of inhibiting migration of endogenous repair cells and preventing axonal regrowth. The following review was prepared by reading and discussing over 200 research articles in the field published in PubMed and selecting those with significant impact and/or controversial points. This article highlights structural and functional features of the normal adult CNS ECM and then focuses on the reactions of glial cells and changes in the perilesion border that occur following spinal cord or contusive brain injury. Current research strategies directed at modifying the inhibitory perilesion microenvironment without eliminating the protective functions of glial cell activation are discussed.     

颈椎病的诊断与治疗

颈椎病是指颈椎椎间盘退行性改变及其继发病理改变累及周围组织结构,出现相应的临床表现.颈椎病的诊断必须具备以下条件：①有颈椎病的一些临床表现;②影像学显示颈椎间盘或椎间关节有退行性改变;③影像学征象必须与临床表现相一致.     

腰椎间盘突出的中医辨证分型与X线CT影像学诊断的初探

１材料与方法收集作者中医门诊诊断腰椎间盘突出症病人３０例。按中医临床辨证分型 ,并经Ｘ线及ＣＴ影像学检查。其中 :男性２８例 ;女性２例。年龄在３０岁以上者２３例 ,２０～３０岁者７例。以Ｌ４、Ｌ５ 椎间盘脱出者１７例 ,以Ｌ５、Ｓ１ 脱出者１３例。一年四季均可发病。多以腰腿痛、活动失利而求医。２中医辨证分型２．１气滞血瘀型 :５例。多数可有明显外伤病史 ,损伤后经脉破损 ,血离经坠 ,瘀血贯脊 ,气血瘀阻经络 ,运行不畅。不通则痛。痛苦貌 ,步履艰难 ,两手插腰 ,挺胸。舌质紫暗 ,边有瘀斑 ,苔光 ,脉涩或弦数。２．２风寒湿滞…     

星状神经节阻滞治疗顽固性呃逆的疗效观察

我科自1999-01～2005-07对院内经药物、针灸、咽喉迷走神经刺激等方法治疗无效,持续72 h以上顽固性呃逆患30例,采用星状神经节阻滞的方法,收到了良好的效果,现报告如下.