盐酸左氧氟沙星与利巴韦林注射液在4神输液中配伍的稳定性考察

左氧氟沙星系第三代氟喹诺酮类抗菌药中最为优良的药物之一。目前广泛应用于呼吸系统、泌尿系统、生殖系统、消化系统等细菌感染。利巴韦林为广谱抗病毒药，对多种RNA和DNA病毒有抑制作用，对有细菌与病毒洽并感染者，临床上常同时使用。二者能否混合在4种常用输液中静脉滴注，尚未见报道，本实验根据临床用药习惯，对盐酸左氧氟沙星与利巴韦林在4种常用输液中的配伍稳定性进行了实验考察。现将结果报告如下。     

氟伐他汀对缺血性脑卒中患者的疗效观察及护理措施

Objective To explore the effect and nursing main points of fluvastatin on the patients with cerebral arterial thrombosis. Methods Eighty-five patients with cerebral arterial thrombosis were randomly divided into three groups. Group Ⅰ was the negative control group. Group Ⅱ was the conventional-dose therapy group and group Ⅲ was the high-dose therapy group. Each group was treated with related therapy and care. The blood lipids in all groups were tested before the treatment, 4 weeks, 12 weeks and 24 weeks after the treatment; the carotid intima-media thickness (IMT) were measured by the Germany SEQUOIAS-512-B ultra machine before the treatment and 24 weeks after the treatment; At the same time, the side effects of fluvastatin were recorded. Results The results of blood lipid tests showed that the LDL, TC and TG in two treated groups were significantly decreased compared to negative control group (P<0.05). After treated for 24 weeks, the carotid intima-media thickness (IMT) in two treated groups were significantly reduced (P<0.05); the side effects of fluvastatin were infrequent and there was no significant different among the three groups (P>0.05). Conclusion The effects of different doses of fluvastatin on cerebral arterial thrombosis were significantly different. With the dose of fluvastatin increased, the serum LDL-L and TC reduced more obvious and the inhibition on carotid atherosclerosis shows more obvious, and the side effects did not increased.     

硬膜外麻醉应用于腹腔镜胆囊切除术的探讨

目的 探讨硬膜外麻醉应用于腹腔镜胆囊切除术（LC）能否保证病人安全并满足手术的要求。方法 选择95例择期腹腔镜胆囊切除病人全部采用硬膜外麻醉。穿刺部位：男性T8～9；女性T9～10，面罩吸氧，静注1／2氟芬合剂（氟哌啶5mg，芬太尼0．1mg）辅助麻醉。Detex仪器检测HR、BP、ECG、SpO2。结果 除1例术中出血开腹手术和1例过度肥胖硬膜外穿刺失败改为全麻外，其他病人全部在硬膜外下顺利完成手术，监测结果均在正常范围。血气分析，气腹后25min术中pCO2偏高，PO2明显升高；术后35min时，PO2比术中升高，其他指标无明显变化。结论 LC用硬膜外麻醉操作简单，在面罩吸氧和静脉辅助麻醉下效果满意，术中平稳，减少生理干扰，保证了病人的安全，达到手术的要求，术后恢复快，无并发症发生。     

格拉司琼不同给药模式对曲马多镇痛病人胃肠动力的影响

盐酸格拉司琼是一种高效高选择性的5-羟色胺受体拮抗剂，它选择性地作用于5-羟色胺受体，从而有效控制和治疗恶心、呕吐。本研究拟对其对曲马多术后镇痛引起恶心、呕吐(PONV)的防治效果与氟哌利多进行比较，并观察其合理的给药模式。     

氟中毒状态下大鼠晶体的形态学改变

为了解氟中毒状态下实验动物的晶体形态学改变，以75或100mg／L的氟化钠溶液造成Wistar鼠的氟中毒，并以正常饮水的大鼠作为对照组。在供毒后1、2、4、6个月以裂隙灯显微镜进行晶体的形态学观察。结果：80．1%(23／28)的氟中毒大鼠晶体出现了程度不同的前囊下、皮质、核的混浊，而对照组仅有10.5%(2／19)的晶体出现了皮质及核的混浊，但无前囊下混浊，且程度较轻。两组差异具有非常显意义(P<0．01)。结论：实验性氟中毒可造成晶体形态学改变。     

安氟醚麻醉前后对细胞染色体影响的研究

本文观察了安氟醚麻醉前后对人淋巴细胞姐妹染色单体互换(SCE)、染色体畸变(CA)、微核(MN)的影响,与普鲁卡因静脉麻醉对照,结果表明,麻醉前和麻醉后SCE、CA、MN改变无意义,P>0.05,表明安氟醚对人类染色体无损伤作用。     

新氟喹诺酮抗菌药

自从唆诺酮类抗菌药问世以来，以其抗菌谱广、抗菌活性强、组织分布广、细胞内渗透性强、不良叵应相对少等特点被广泛应用于临床，已成为临床治疗细菌感染性疾病的主要药类之一。由于目前临床常用的氟唆诺酮药物如环丙沙星和氧氟沙星对肺炎球菌、葡萄球菌等革兰阳性需氧菌l，J及脆弱类杆菌等氏氧菌的抗菌活性相对较低，同时临床上已出现耐唆诺酮菌株，限制了这类药物的发展。近年来，一系列氟唆诺酮药物的新品种相继问世，它们包括：司帕沙星（sparfloxaci）、