外周血免疫细胞在NAFLD疾病进展中的诊断价值

近日,范建高教授应《柳叶刀》旗下子刊EBioMedicine(影响因子8.413分)编辑部邀请,与博士生林双喆在线发表综述:Peripheral immune cells in NAFLD patients:A spyhole to disease progression,EBioMedicine 2021 doi.org/10.1016/j.ebiom.2021.103768,系统分析非酒精性脂肪性肝病(NAFLD)及其不同临床病理类型亚组患者循环外周血液各种免疫细胞的特征性变化,并探讨了外周血免疫细胞变化用于无创诊断与评估NAFLD的严重类型非酒精性脂肪性肝炎(NASH)的潜在价值。     

经鼻高流量氧气湿化治疗老年慢性阻塞性肺疾病急性加重合并呼吸衰竭的可行性研究

ObjectiveTo investigate the feasibility of transnasal heated humidified high flow nasal cannula oxygen therapy (HFNC) in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD) with respiratory failure in elderly patients. MethodsA total of 176 elderly patients with AECOPD complicated with respiratory failure who were hospitalized at Peking University Shougang Hospital from December 2016 to January 2022 were enrolled, including 82 patients in an HFNC group and 94 patients in an NPPV group. After treatment, pulse oxygen saturation (SPO₂), arterial partial pressure of carbon dioxide (PaCO₂), oxygenation index (OI), respiratory rate (RR), heart rate (HR), mean arterial pressure (MAP), comfort score, discharge rate, rate of endotracheal intubation, rate of transfer to intensive care unit (ICU), and mortality were compared between the two groups. The independent sample t-test was used for comparison between the two groups. Statistical data are expressed in percentage or number of cases and the χ² test was used for their comparisons. ResultsThe SPO₂ values at 30 min, 1 h, and 6 h were significantly higher in the HFNC group than in the NPPV group (t=-2.049,-2.618, and -3.314, P=0.043, 0.010, and 0.001, respectively). SPO₂ before discharge was significantly lower than that of the NPPV group (t=2.162, P=0.033), but OI at each time point and before discharge had no statistical significance (P＞0.05). MAP at 6 h was significantly higher in the HFNC group than in the NPPV group (t=-2.209, P=0.029), but within the normal range. HRs at 2 h and 3 h in the HFNC group were significantly higher than those of the NPPV group (t=-2.199 and -2.336, P=0.030 and 0.021, respectively). There were no significant differences in RR, HR, or MAP between the two groups at other time points and before discharge (P＞0.05). There was no significant difference in PaCO2 between the two groups (P＞0.05). Comfort score in the HFNC group was significantly higher than that of the NPPV group (t=-46.807, P＜0.001). There were no significant differences in discharge rate, ICU transfer rate, endotracheal intubation rate, and mortality between the two groups (P＞0.05). ConclusionHFNC is as effective as NPPV in treating elderly patients with AECOPD complicated with type Ⅰ or mild type Ⅱ respiratory failure, and HFNC is more comfortable than NPPV.     

腹腔镜完全腹膜外疝修补术治疗成人腹股沟疝效果观察

目的探讨腹腔镜完全腹膜外疝修补术(TEP)与开放式无张力疝修补术(OTFH)治疗成人腹股沟疝的效果。方法选取2016-01—2019-02间商丘市立医院和虞城县人民医院收治的80例成人腹股沟疝患者,将38例接受OTFH术的患者作为对照组,将42例接受TEP术的患者作为腹腔镜组。比较2组的疗效及随访期间的复发情况。结果全部患者均顺利完成手术。2组手术时间差异无统计学意义(P0.05)。腹腔镜组术后胃肠功能恢复时间、住院时间、并发症发生率均少于对照组,差异有统计学意义(P0.05)。术后随访3个月～1 a期间,2组均未出现复发。结论 TEP术治疗成人腹股沟疝并发症少、术后康复快、安全、有效。     

舒利迭联合无创通气治疗老年急性加重期慢性阻塞性肺疾病合并Ⅱ型呼吸衰竭的疗效

目的探讨舒利迭联合无创通气治疗老年急性加重期慢性阻塞性肺疾病(AECOPD)合并Ⅱ型呼吸衰竭临床效果。方法 120例AECOPD合并Ⅱ型呼吸衰竭患者,按照数字表法分为对照组与观察组,各60例。对照组使常规治疗联合无创通气治疗,观察组在对照组基础上联合使用舒利迭治疗。对比治疗前后患者血气指标、生理指标、治疗有效率、转归。结果观察组治疗后1、3 d动脉血氧分压(Pa O2)、动脉血二氧化碳分压(Pa CO2)、p H、血氧饱和度(Sa O2)均比治疗前有明显改善(P0.05),治疗后同时间点观察组Pa O2、Pa CO2、p H、Sa O2均比对照组改善明显(P0.05);观察组治疗后1、3 d心率(HR)、呼吸频率(RR)、血压(BP)均比治疗前有明显改善(P0.05),治疗后同时间点观察组HR、RR、BP均比对照组改善明显(P0.05);观察组治疗有效率93.33%,明显高于对照组(76.67%,χ2=6.134,P=0.001);对照组转插管机械通气治疗发生率16.67%,观察组转插管机械通气治疗发生率1.67%,两组差异显著(χ2=8.147,P=0.000);对照组住院时间平均为(30.1±3.1)d,明显长于观察组住院时间〔(20.2±3.5)d,t=6.544,P=0.000〕。结论舒利迭联合无创通气显著改善AECOPD合并Ⅱ型呼吸衰竭临床疗效,值得临床推广应用。     

无缝隙护理在口腔正畸患者中的应用

目的: 评价无缝隙护理对口腔正畸患者口腔健康的影响。方法: 2019年1月至2020年6月收治的200例口腔正畸患者,按照双色球法将200例患者分为对照组和观察组各100例。对照组实施常规护理,观察组实施无缝隙护理。护理前后评估两组患者牙龈指数、牙菌斑指数和口腔健康状态并进行比较。结果: 两组护理前的牙龈指数、牙菌斑指数、口腔健康状态（言语受限、疼痛、咀嚼、其他症状）比较,差异无统计学意义（P>0.05）;观察组护理14 d后、护理28 d后的牙龈指数、牙菌斑指数低于对照组,护理28 d后口腔健康状态优于对照组,差异有统计学意义（P<0.05）。结论: 无缝隙护理可有效改善口腔正畸患者的牙龈指数与牙菌斑指数,可提高患者的口腔健康水平。     

心肌缺血的运动心电信号无创检测方法

目的：探讨心肌缺血的运动心电信号无创检测方法。方法：选取2012年－2013年来我院治疗的心肌缺血患者120例，随机平均分成对照组和实验组。其中实验组60例患者使用运动心电信号无创检测方法，而对其余60例患者为对照组采取常规方法，对比两组的检测效果病情缓解度。结果：在实验组经过运动心电信号无创检测之后，实验组显效35例，有效20例，无效 5例，对照组显效8例，有效12例，无效40例，相对于对照组来说，效果更好，检测结果更准确，病人恢复情况更好，运动心电信号无创检测对于检测疾病并且对于预防和减少并发症的发生有较好的效果，说明此方式对于促进患者康复和缩短住院时间有一定积极效果。结论：心肌缺血的运动心电信号无创检测方法对于患者疾病检测，促进患者康复和缩短住院时间有一定积极意义。     

不完全逆行射精1例

<正>患者,男,33岁,婚后未避孕未育3年。无外伤手术史,无高血压病、糖尿病等慢性疾病,未服用特殊药物。患者在外院检查精液中未见精子,曾诊断为无精子症,予以他莫昔芬和"中成药"治疗。药物治疗1个月后复查精液中出现精子,精液量1.7ml,精子浓度6.6×10~6/ml。但是继续药物治疗1个月后复查,精液中再次无精子,本次精液对应的精浆生化果糖2.074×10~(-3) mmol,锌8.738×10~(-3) mmol,