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111.
Bahram Dalir-Naghadeh Siamak Asri-Rezaei Naser Alidady 《Comparative clinical pathology》2006,15(3):149-153
Odds ratio was used to evaluate relationship between sepsis in cattle less than 1 year old and mastitis in cows and erythrocyte glutathione peroxides (GSH-PX) activity as an indicator of selenium status. Data were from 178 blood samples collected from referred cases to Urmia University, Veterinary Teaching Hospital. Low activity of GSH-PX was significantly associated with higher odds of developing sepsis (P=0.005) in young cattle and mastitis (P=0.044) in adult cows. The odds ratios for the low activity of GSH-PX on incidence of sepsis and mastitis were 4.74 and 3.95, respectively. Selenium deficiency was associated with sepsis in young cattle and mastitis in cows, i.e., cattle with low activity of erythrocyte GSH-PX were at increased risk of sepsis and mastitis. 相似文献
112.
The property of aerobic glycolysis commonly possessed by malignant cells points to a weakness in oxidative metabolism which has been equated in some tumours with partial uncoupling of oxidative phosphorylation. The suggestions are made, first, that this endogenous defect may account for spontaneous cell death
, and, second, that its accentuation would inflict extensive tumour injury upon sensitive neoplasms. Certain drugs not in current use for the treatment of malignant disease are known to be able to interfere selectively with energy metabolism in sensitive tumours to such an extent that widespread necrotisation ensues. The drugs activate an endogenous destructive mechanism that appears to require oxygen. Liminal therapy, the maintenance of continuous destructive pressure on sensitive growths in such a manner that maximal anti-tumour activity in terms of interference with energy production is not achieved at any one time, and under conditions in which the oxygen supply is only partly depleted, is put forward as a possible means of achieving complete and selective tumour destruction
. 相似文献
113.
Alberto Utrero-Rico Javier Ruiz-Hornillos Cecilia González-Cuadrado Claudia Geraldine Rita Berta Almoguera Pablo Minguez Antonio Herrero-González Mario Fernández-Ruiz Octavio Carretero Juan Carlos Taracido-Fernández Rosario López-Rodriguez Marta Corton José María Aguado Luisa María Villar Carmen Ayuso-García Estela Paz-Artal Rocio Laguna-Goya 《The Journal of allergy and clinical immunology》2021,147(5):1652-1661.e1
114.
新型MAO钛基生物材料的血液相容性研究 总被引:1,自引:1,他引:1
目的初步评价新型钛基材料的血液相容性。方法采用新西兰大白兔新鲜全血,抗凝后分别与实验组和阳性对照、阴性对照组接触,用紫外-可见光分光光度计比色,评价各组的溶血率。实验符合国际化标准组织规定要求。结果新型微弧氧化钛基材料直接接触溶血率为0.79%,符合医用材料的溶血率不大于5%的要求。结论新型钛基材料具有良好的血液相容性。 相似文献
115.
为了评价游离前列腺抗原(F PSA)/前列腺抗原(PSA)比值和PSA动态变化(年变化率)在前列腺癌诊断中的应用价值。本文应用ELISA追踪检测PSA在4~10μg/L范围患者在不同时段内PSA水平,并与正常人进行对照,利用ROC曲线,评价FPSA/PSA比值和PSA年变化率两项指标在前列腺癌诊断时的预示价值。结果表明:前列腺癌患者的FPSA/PSA比值和PSA年变化率与非前列腺癌组之间具有显著性差异(P〈0.001),当FPSA/PSA比值的临床判断值为0.21时,诊断灵敏度为93.5%,特异性为91.4%;当PSA年变化率的临床判断值为0.85%。诊断灵敏度为82.6%,诊断特异性为97.9%。前列腺增生患者FPSA/PSA比值与正常人之间无显著性差异(P〉0.05),而PSA年变化率与正常人比较具有显著性差异(P<0.001)。提示FPSA/PSA比值和PSA年变化率有助于PSA在4~10μg/L范围的患者前列腺癌的诊断。 相似文献
116.
117.
P. Magnus A. -L. BØrresen P. K. Opstad J. F. Bugge K. Berg 《European journal of applied physiology》1984,53(1):21-24
Summary Effects of four days of intense physical activity on serum concentrations of total triglycerides, total cholesterol and apolipoproteins A-I, A-II, and B were studied in 35 well-trained young men. Serum total triglyceride levels decreased to 70% of baseline levels after 24 h, and fell further to 50% of baseline levels after 4 days. Serum levels of total cholesterol fell steadily to about 80% of baseline levels on the 4th day. Apo-B levels fell to 85% of baseline levels after 24 h, and remained at that level. Apo A-I fell to about 90%, and apo A-II to about 80% of baseline levels, causing a significant increase in the ratio of apo A-I to apo A-II. The intraindividual changes in apo B were positively correlated to changes in cholesterol during the first day (r=0.60). The changes in apo A-I and apo A-II had no significant correlation with changes in total cholesterol or triglycerides, or with one another, suggesting that apo A-I and apo A-II are metabolized independently during conditions of hard physical exercise. 相似文献
118.
K. J. Ullrich G. Rumrich K. Neiteler G. Fritzsch 《Pflügers Archiv : European journal of physiology》1992,420(1):29-38
In order to study the quantitative structure/activity relationship of organic cation transport across the contraluminal side of the proximal renal tubule cell, the stopped-flow capillary microperfusion method was applied and the inhibitory potency (apparent K
i values) of different homologous series of substrates against N
1-[3H]methylnicotinamide (NMeN+) transport was evaluated. Aniline and its ring- or N-substituted analogues as well as the aminonaphthalines do not interact with the contraluminal NMeN+ transporter except for the quaternary trimethylphenylammonium and pararosaniline, which bear a permanent positive charge, and for 1,8-bis-(dimethylamino)naphthaline, which forms an intramolecular hydrogen bond. If, however, one or more than one methylene group is interposed between the benzene ring and the amino group, the compounds interact with the contraluminal NMeN+ transporter in proportion to their hydrophobicity parameter, i.e. the octanol/water partition coefficient (log octanol). The catecholamines and other hydroxyl-substituted phenylethyl analogues also follow this rule. In addition, the N-heterocyclic pyridine, quinoline, isoquinoline and acridine analogues also interact with the contraluminal NMeN+ transporter, when their pK
a values are higher than 5.0, and, an inverse correlation between pK
a and log K
i, NMeN was observed. An exception to this rule are those hydroxy compounds of pyridine, quinoline and isoquinoline that show tautomerism. These compounds slightly inhibit NMeN+ transport despite low pK
a values. The quaternary nitrogen compounds of aniline and the N-heterocyclic analogues, as far as tested, all interact with the contraluminal NMeN+ transporter in relation to their hydrophobicity. The data indicate that the contraluminal NMeN+ transporter interacts with N-compounds according to their hydrophobicity and/or according to their basicity (affinity to protons). The reason for deviation of the aniline analogues and the OH-tautomeric heterocyclic N-compounds from this behaviour is discussed. 相似文献
119.
Yewande E. Odeyemi ODene Lewis Julius Ngwa Kristen Dodd Richard F. Gillum Alem Mehari 《Journal of the National Medical Association》2019,111(1):94-100