HELLP syndrome associated with factor V R506Q mutation

The pathogenesis of HELLP (haemolysis, elevated liver enzyme and low platelet count) syndrome, a severe presentation of pre-eclampsia, is still an enigma. Activated protein C resistance resulting from a mutation in coagulation factor V has recently emerged as the leading cause of thrombosis in pregnancy. We report on two patients with HELLP syndrome who were found to be heterozygous for factor V R506Q mutation, leading to activated protein C resistance. These findings suggest that the pathogenesis of HELLP syndrome is associated with a thrombotic process, and point to the potential benefit of anti-thrombotic therapy in this condition.     

Recurrent cerebral venous infarcts and superior vena cava obstruction: case report

Abstract We report a patient with repeated venous infarcts in the occipital lobe and occlusion of the superior vena cava. The pathogenetic relationships between the superior vena cava occlusion and the brain infarcts are discussed. High pressure in the superior venous territory and incomplete patency of the transverse sinus are probably responsible for the venous infarcts. Received: 12 July 1996 Accepted: 27 August 1996     

超声显像诊断下肢深静脉血栓的临床应用

目的：探讨超声诊断下肢深静脉血栓的临床价值。方法：应用ＨＰ８５００多功能彩超仪，７．５ＭＨｚ线阵探头，外周血管软件检查临床疑下肢深静脉血栓３２例，另取１２例正常人２４条下肢深静脉作对照。２ＤＵＳ显示形态学改变，ＣＶＩ及ＰＷ模式观察血流状态。结果：超声检出下肢深静脉血栓形成２５例，除外血栓形成７例。２ＤＵＳ显示血栓形成部位血管内径明显增大，与患者健侧同水平深静脉内径进行配对ｔ检验，ｔ＝１３．８２，Ｐ     

Vascular Access for Therapeutic Plasma Exchange

Abstract: Adequate venous access is an essential component of therapeutic plasma exchange (TPEX). The simplest kind of venous access is venipuncture of antecubital veins, but this technique may be limited by venous size or scarring following the procedure, requiring the placement of a specialized vascular access device (VAD). VADs provide reliable central venous access and may remain in place for several weeks or months, depending on the VAD and the venous site chosen. Their use, however, is potentially limited by the risk of complications. We discuss indications for insertion, choice of catheter and access site, and complications of VAD placement for TPEX.     

Vein of Galen and sinus thrombosis with bilateral thalamic infarcts in sickle cell anaemia: CT follow-up and angiographic demonstration

A 2-year-old boy with known sickle cell disease presented in acute coma. CT revealed bilateral thalamic infarcts and incomplete sinus thrombosis. Angiography confirmed thrombosis of the straight sinus and vein of Galen.     

体外丹参、藻酸双酯钠对脑血栓形成患者红细胞与内皮细胞粘附的影响

丹参、藻酸双酯钠是临床治疗脑血管病的常用药。本研究发现，在体外流场中用丹参、藻酸双酯钠分别处理脑血栓形成病人的红细胞后，此红细胞与培养的人脉静脉内皮细胞的粘附数目明显减少、粘附强度明显减弱；而且，在临床常用剂量下藻酸双酯钠的这种抗粘附作用优于丹参。认为丹参、藻酸双酯钠的这种抗粘附作用可能是临床用以治疗脑血栓形成的一个重要机理。     

髂股静脉血栓形成血浆降钙素基因相关肽测定的临床意义

目的　探讨降钙素基因相关肽对髂股静脉血栓形成的影响。方法　回顾性分析 5 0例髂股静脉血栓形成患者降钙素基因相关肽 (CGRP)的水平 ,以及对比研究联合应用尿激酶和复方丹参注射液治疗前后CGRP的变化。结果　急性髂股静脉血栓形成患者均存在高水平的CGRP ,与对照组比较具有显著性差异 (P <0 0 1) ;治疗后 6h血浆CGRP水平明显升高 ,3d达到最高峰 ,15d接近正常水平。结论　CGRP可以作为髂股静脉血栓形成的诊断指标之一 ,联合应用尿激酶和复方丹参注射液对髂股静脉血栓形成有较好的疗效。