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51.
52.
目的 比较用硝酸甘油和合心爽治疗98例不稳定型心绞痛的疗效。方法 随机分组,分别静滴合心爽和硝酸甘油,以难治性心绞痛、心肌梗塞或缺血性猝死为治疗终点。结果 发展为难治性心绞痛或心肌梗塞病例在合心爽组为5人,硝酸甘油组为11人,发生心肌梗塞者合心爽组3人,硝酸甘油8人,缺血性猝死者合合爽组无,硝酸甘油组1人。结论 静脉用合心爽治疗不稳定型心绞痛疗效优于硝酸甘油(P〈0.001)。 相似文献
53.
葛根素治疗52例冠心病心绞痛疗效观察 总被引:5,自引:0,他引:5
目的:探讨冠心病心绞痛药物治疗的效果。方法:将104例冠心病心绞痛患者随机分成两组:A组选用葛根素注射液500mg加入5%葡萄糖500ml静脉滴注治疗,B组采用镁-极化液500ml静脉滴注,1次/d,14d为1个观察疗程。结果:缓解心绞痛症状,A组总有效率达84.6%,与B组总有效率42.3%相比较有非常显著差异(P〈0.01)心肌缺血改善后心电图评定,A组总有效率69.23%,与B组总有效率34 相似文献
54.
目的 观察低分子肝素治疗老年人不稳定型心绞痛的疗效。方法 将101例不稳定型心绞痛患者随机分为A、B两组。在常规治疗基础上A组给予低分子肝素腹部皮下注射;B组给予等量生理盐水皮下注射。结果 A组心绞痛发作频率比B组明显减少(P〈0.01)。心电图ST段及T波较对照组明显改善。A组总有效率90%,B组总有效率54%(P〈0.01)。A、B组治疗期间均未见出血等副作用。结论 低分子肝素治疗老年人不稳定 相似文献
55.
SERUM LEVELS OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH ANGINA PECTORIS AND ACUTE MYOCARDIAL INFARCTION 总被引:4,自引:0,他引:4
INTRODUCTION Vascularendothelialgrowthfactor (VEGF)orvascularpermeabilityfactor (VPF)consistsofafamilyofpolypeptideisoformsthatspecificallyregulateendothelialcellfunction ,includingenhancementofangiogenesis( 1) ,enhancementofmicrovascularpermeability ( 2 ) ,an… 相似文献
56.
速避凝治疗不稳定性心绞痛的临床观察 总被引:1,自引:0,他引:1
目的 评价速避凝治疗不稳定性心绞痛(UA)的临床疗效。方法 将筛选的80例UA患者随机分成治疗组(40例,皮下注射速避凝注射剂)和对照组(40例,静点前列腺素E1注射剂)。治疗期间两组均不用其他除脂、降压及血管扩张剂。心绞痛发作程度较重且频繁时,可临时给硝酸甘油片舌下含化,并做记录。结果 治疗后心绞痛发作情况及心电图改变两组对照经t检验,差异有显著性至非常显著性。治疗组总有效率为85%,对照组总有 相似文献
57.
Jan -Erik Karlsson Anders Björkholm Eva Nylander Jan Ohlsson Lars Wallentin 《The International Journal of Cardiac Imaging》1995,11(2):127-137
The additional value of thallium-201 SPECT to a conventional exercise test for the identification of patients with severe coronary lesions was evaluated in 170 men, one month after an episode of unstable coronary artery disease. Severe coronary lesions at coronary angiography — defined as three vessel disease, left main stenosis or proximal left anterior descending artery stenosis as part of two vessel disease — were observed in 45.9%. In the SPECT image, the left ventricular myocardium was divided into nine segments and each segment was classified as either normal (=0), reduced uptake (=1) or uptake defect (=2). The sum of gradings in all segments post-exercise was denoted SPECT score. The patients were divided into nine different groups regarding ST-depression during exercise (no ST-depression, ST-depression in 1–2 leads or 3 leads) and SPECT score (no SPECT score, 1–3 scores or 4 scores). Severe coronary lesions were, in 68% identified by SPECT score 4 and in 65% by ST-depression in 1 lead at exercise test. The specificity for identification of severe coronary lesions was, for both tests, 65%. SPECT score 4 and/or ST-depression in 3 leads identified 82% of the patients with severe coronary lesions with a specificity of 63%. Furthermore, SPECT score 3 identified more patients with isolated proximal left anterior descending artery stenosis than ST-depression alone at exercise test. 相似文献
58.
Optimizing the treatment of unstable angina 总被引:2,自引:0,他引:2
Cannon CP 《Journal of thrombosis and thrombolysis》1995,2(3):205-218
Unstable angina and non-Q-wave myocardial infarction (MI) are at the center of the spectrum of myocardial ischemia, which ranges from stable angina to acute Q-wave MI. In addition to clinical evaluation, cardiac specific markers such as troponin T or I can assist in early diagnosis, triage, and risk stratification. Antithrombotic therapy with aspirin and heparin have been shown to improve the outcome of patients with acute ischemic syndromes. Thrombolytic therapy does not appear to be beneficial in these syndromes. Antiischemic therapy remains an important component of the overall therapy. A strategy of early coronary angiography and revascularization leads to a similar long-term outcome as compared with a more conservative strategy of revascularization for recurrent ischemia, but the early invasive strategy is more expeditious as a large number of conservatively treated patients have recurrent ischemia. At present, many new antithrombotic agents are under active investigation, with the hope that they will lead to further improvement in the clinical outcome of patients with acute ischemic syndromes. 相似文献
59.
L. L. Thomsen H. K. Iversen C. Emmeluth P. Bie 《European journal of clinical pharmacology》1995,48(2):139-142
Endothelin-1 and nitric oxide play an important regulatory role in the control of vascular smooth muscle tone. Nitroglycerin (NTG), a nitric oxide donating drug, may inhibit endothelin production. In this double-blind placebo-controlled crossover study, plasma levels of endothelin-1 were measured before and immediately (5–30 s) after 80 min infusion of NTG (glyceryl trinitrate) or saline in 12 healthy subjects. On two different days separated by at least 1 week, NTG in four different doses, 0.015, 0.25, 1.0, and 2.0 g·kg–1·min–1, or placebo (isotonic saline) was infused successively for 20 min each dose. During the infusion blood pressure and heart rate were measured. NTG infusion significantly decreased systolic blood pressure from 112.4 to 103.4 mmHg and pulse pressure from 39.3 to 29.5 mmHg. Heart rate increased from 62.7 to 73.1 beats·min–1. No changes in endothelin-1 plasma levels were induced by NTG infusion (2.4 pg·ml–1 before NTG vs. 2.7 pg·ml–1 after NTG) and placebo infusion also did not affect plasma endothelin-1. It is concluded that venous plasma levels of endothelin-1 are not altered immediately after NTG infusion. 相似文献
60.
血清铁蛋白,血清铁与冠心病及其有关危险因素关系的临床研究 总被引:1,自引:0,他引:1
目的:研究血清铁蛋白(SF)、血清铁(SI)与冠心病(CHD) 之间的关系以及SF、SI与CHD有关危险因素的相关关系。方法:测定43 例心肌梗塞(MI),44 例心绞痛(AP) 患者的SF、SI、血脂、血糖(BG)、血压、腰臀比(WHR) 、体重指数(BWI)水平,与40 例健康对照组进行分析。结果:AP组、MI组男、女、总体SF水平分别明显高于对照组(P< 0.05~0.001),但女性升高不如男性明显;SF水平与WHR、甘油三脂(TG)、低密度脂蛋白(LDL)呈正相关(r= 0.46,0.34,0.44),与高密度脂蛋白(HDL)呈负相关(r= - 0.33)。结论:体内SF增加是AP、MI的主要易发因素之一;SF水平受营养因素特别是某些脂代谢及腹部脂肪分布的影响 相似文献