EVOKED POTENTIALS OF OBSESSIVE-COMPULSIVE DISORDER： STATE OR TRAIT MARKER

Objective To investigate the status of evoked potentials in obsessive-compulsive disorder(OCD). Methods Evoked potentials P300, auditory brainstem response (ABR) and visual evoked potential ( VEP) were recorded from 35 OCD patients and 28 normal controls (NC) with a Nicolet Spirit Instrument. 23 of the OCD patients were followed up after 5 months with the same markers. Results Compared with NC, OCD patients showed decreased P3 of P300 amplitude (OCD group 3. 5 ±1. 6μv vs. NC group 5.9 ±2. 1μv, P <0. 01), delayed V latency (6.4±0. 4ms vs. 5. 5 ±0. 3ms, P <0. 01) and increased V amplitude(0. 35±0. 1μv vs. 0. 16 ±0.09μv, P <0. 05) of ABR and delayed P2 of VEP latency (199±39ms vs. 183±28ms, P <0. 05). The follow-up measures of evoked potentials suggested that decreased P3 of P300 amplitude and delayed P2 of VEP latency might be state markers of OCD, while decreased V amplitude and delayed V of ABR latency might be trait markers of OCD. Conclusion The changes of P300 and VEP are related to clini     

NSCLC患者血清肿瘤标志物水平与肿瘤骨转移之间关系的研究

目的:探讨非小细胞肺癌患者治疗前血清肿瘤标志物水平与肿瘤骨转移之间的相关性。材料和方法:受检患者58名治疗前均行血清Cy21-1、SCC、NSE、CEA和CA15-3测定和SPECT全身骨显像。结果:血清Cy21-1和CA15-3水平与全身骨显像结果相关。(P<0.05),血清SCC,NSE及CEA水平则无相关(P>0.05)。结论:血清中Cy21-1和CA15-3升高水平与肿瘤骨转移之间存在正相关关系,尤以Cy21-1为著。     

Post-prandial cardiovascular responses in man after ingestion of carbohydrate,protein or fat

Changes in cardiac output and in superior mesenteric arterial flow were followed with Doppler ultrasound techniques in five young, healthy persons for 2 h after ingestion of medium-sized (4 MJ), fluid meals containing either carbohydrate, protein, fat or water only. Measurements were carried out before meals and at regular post-meal intervals, during which mean arterial blood pressure was also followed. All energy-containing meals caused marked and gradually developing post-prandial increases in cardiac output as well as in superior mesenteric arterial flow. The maximum flow levels were reached in the course of 30–60 min and maintained until the observations ended after 2 h. The intake of water caused no such flow increases. There were considerable interpersonal variations in the size and in the speed of development of the flow increases after the three types of energy-containing meals. The flow-increasing effects of the three meal types were not significantly different, even if the most marked increases (median values about 1 1 min^-1 for both cardiac output and superior mesenteric arterial flow) occurred after carbohydrate meals. The marked effects on circulation of the three food components were also revealed in the calculated, integrated amounts of ‘extra’ cardiac output and superior mesenteric arterial flow observed in the course of the 2 h following the meal. Values of more than 100 1 for such ‘extra’ flows were seen after carbohydrate meals. The marked ingestion-released increase in blood flow to the splanchnic organs is apparently partly met by an increase in cardiac output, and partly by some redistribution of flow, which benefits the digestive system.     

SNP及其在畜牧业中的应用前景

SNP(single nucleotide polymorphisns-单核苷酸多态性)是继限制性片段长度多态性和微卫星之后，新发展起来的第3代分子标记。已成为一类新的遗传标记，广泛应用于基因定位、克隆和遗传多样性研究。本文介绍了SNP的特性、检测方法及其在畜牧业研究生产中的广泛利用前景。并提出了SNP研究中遇到的一些问题。     

Distribution and structure of identified tonic and phasic synapses between L-neurones in the locust ocellar tract.

The ultrastructures and distributions of the discrete anatomical synapses which constitute two distinct types of output connections made by individual ocellar L-neurons, L1-3, are described. Outputs to neurones L4-5 are excitatory and transmit tonically, whereas reciprocal connections among the three L1-3 neurones are inhibitory and incapable of transmission for longer than a few milliseconds. The tonically transmitting synapses are located in the lateral ocellar tract and are made between the axons of L1-3, which do not receive inputs, and short branches of L4-5, which make no outputs. Each excitatory connection is composed of a few hundred discrete anatomical synapses, each characterised by a bar-shaped presynaptic density which is 0.15-1.5 microns in length and associated with a large number of round synaptic vesicles. Two postsynaptic profiles are apposed to each presynaptic density. Associated with tonic synapses are abundant invaginations of the presynaptic membrane. Synapses of the reciprocal, inhibitory, phasic connections occur in the protocerebral arbors of L1-3, among numerous output synapses of these neurones. Each phasic connection is composed of a few tens of discrete anatomical synapses. Each bar-shaped presynaptic density is associated with two postsynaptic profiles, and is 0.1-1.0 microns long. Compared with the tonic, excitatory connection, there are fewer vesicles and fewer invaginations of the presynaptic membrane associated with each synapse.     

三维超声技术及其在肝癌诊治中的应用

介绍三维超声成像技术的原理,讨论三维超声在肝癌的诊断性应用及在肝脏手术和介入中的治疗性应用。     

吻合血管的胸脐皮瓣移植修复足踝部大面积软组织缺损

目的 探讨吻合血管的胸脐皮瓣移植修复足踝部大面积软组织缺损的临床效果.方法 对18例足踝部大面积软组织缺损(其中11例伴胫前或胫后血管节段损害)采用胸脐皮瓣游离移植修复创面.创面面积12cm×6cm～32cm×12cm.结果 移植皮瓣全部成活,3例足跟部缺损的病人术后因长期磨擦形成足跟部慢性溃疡;3例皮瓣臃肿,需再次手术整形.其余病例外观和足踝部功能恢复满意.结论 胸脐皮瓣为腹壁下动脉供血,血运丰富,血管解剖恒定,血管蒂长,可切取面积大且易于切取,适宜修复足踝部软组织缺损,尤其适用于缺损面积大、胫前或胫后血管之一长节段损害者.     

聚焦超声治疗慢性宫颈炎500例临床分析

目的 探讨聚焦超声治疗宫颈炎的临床疗效.方法 收治慢性宫颈炎700例,分为聚焦超声治疗组(超生治疗组)500例,微波治疗对照组200例.观察其临床症状、体征及疗效.结果 超声治疗组中、重度宫颈炎的疗效明显高于微波对照组,差异有显著意义(P＜0.05);两种方法治疗后,宫颈修复过程中阴道排液、出血等并发症的发生率,超声治疗组明显低于微波对照组,差异有显著意义(P＜0.05).结论 聚焦超声治疗宫颈炎疗效确切,副作用及并发症少,是目前治疗宫颈炎的一种有效方法.     

经腹超声及术中超声在胰腺结石诊断、治疗中的应用

目的:探讨经腹超声及术中超声在胰腺结石诊断、治疗中的价值。材料和方法:对25例胰腺结石患者行经腹和术中超声检查。经腹超声主要观察胰管扩张程度,胰腺结石大小、位置,是否合并胆囊及胆道结石、胰腺假性囊肿等。术中超声观察是否有结石残留。结果:经腹超声显示25例患者主胰管扩张,胰腺实质增粗、增强。结石位于头部9例,位于全胰腺16例,伴有胆道梗阻征象13例,其中合并胆囊及胆道结石8例,并发胰腺假性囊肿3例,合并胰腺癌2例;术中超声形式显示6例未见残留结石,19例有残留结石,手术取出残留结石24枚。结论:经腹超声诊断主胰腺管结石敏感性较高,术中超声在判断残留结石及鉴别胰小管结石与胰腺实质钙化灶方面具有重要价值。