Usefulness of the Model of Human Occupation in the Hong Kong Chinese Context

Questions have been raised about the applicability of Western theory in an Eastern context. Two case studies are used to illustrate how the Model of Human Occupation (MOHO) is useful in problem identification and intervention planning in Hong Kong. The cases illustrate that MOHO provides useful insights to how Chinese culture influences participation of persons with disabilities.     

中医康抚辅以炒茴香热敷法在肾癌根治手术后护理研究

目的：探讨中医康抚辅以炒茴香热敷法在肾癌根治手术后的护理中的作用。方法：收集我院2010年6月—2012年12月收治的肾癌根治术后腹胀患者200例,随机分配到中医康抚组和中医康抚辅以炒茴香热敷法组,比较两组患者的肾癌根治手术后胃肠恢复的情况,并对此进行统计学分析,最后比较两组方法的疗效。结果：采用中医康抚护理组和中医康抚辅以炒茴香热敷法组的患者平均首次排气时间分别为（8.6±1.5）h与（4.8±1.2）h,平均腹胀消失时间分别为（16.2±2.1）h和（8.9±1.6）h;视觉模拟评分到2分时,两组患者的时间分别为（20.9±1.1）h和（16.3±0.5）h,均具有显著统计学差异（P〈0.05）。结论：中医康抚辅以炒茴香热敷法对肾癌根治手术后患者的胃肠功能恢复的疗效更明显。     

中药灌肠治疗晚期癌症肠梗阻临床研究

目的：探讨中药灌肠治疗晚期癌症患者肠梗阻临床疗效以及对患者近期生活质量的影响。方法：将68例晚期癌症合并肠梗阻患者分为两组,对照组34例采用常规治疗,治疗组34例在对照组基础上加用加味大承气汤保留灌肠,每天2次,每次100～150 mL;两组均以7 d为1个疗程;治疗前后生活质量评估采用国际通用的SF-36生存量表。结果：治疗组有效10例,好转18例,无效6例,有效率为82.35%;对照组有效6例,好转11例,无效17例,有效率为50.00%。两组比较差异有统计学意义（P〈0.05）;生存量表的6个维度[生理功能（PF）、躯体疼痛（BP）、总体健康（GH）、生命活力（VT）、情感职能（RE）、精神健康（MH）]积分比较,治疗组优于对照组,两组比较差异有统计学意义（P〈0.05）。结论：加味大承气汤灌肠治疗晚期癌症肠梗阻有较好疗效,且能改善患者的近期生活质量。     

The susceptibility of T5-TG12 of theCFTR gene in chronic bronchitis occurrence in a Chinese population in Jiangsu province,China

Mutations in the cystic fibrosis transmembrane conductance regulator(CFTR) gene have been implicated in the onset of cystic fibrosis and other clinical respiratory disorders.In the present study,we investigated the role of CFTR variations,poly-T,TG-repeats,and M470V in susceptibility to bronchial asthma and chronic bronchitis in a Chinese population in Jiangsu province,China.A total of 72 bronchial asthma patients,68 chronic bronchitis patients,and 117 healthy subjects were included in this study.The Tn-TGm haplotype was sequenced and the CFTR variant M470V was detected using restriction fragment length polymorphism(RFLP).We found that the frequency of T5-TG12-V470 in chronic bronchitis patients was 0.07%,which was notably higher than that in healthy subjects(0.01%) and bronchial asthma patients(0.04%).Thus,the presence of the T5-TG12 haplotype of the CFTR gene is likely to play a role in the development and progression of respiratory conditions,such as chronic bronchitis.     

Xiao-Chai-Hu Tang in Treating Model Mice With D-Galactosamine-Induced Liver Injury

This study explored the effects of a classical Chinese medicine formula- Xiao-Chai-Hu Tang(XCHT) on the model mice with D-galactosamine -induced liver injury. Sixty male imprinting control region (ICR) mice were used in the present study, and they were separated randomly into 6 groups: a normal control group (Group A, n=10), a model control (Group B, n=10), a positive control (Group C, n=10), a low dose of XCHT group (Group D, n=10), a medium dose of XCHT group (Group E, n=10), and a high dose of XCHT group (Group F, n=10). ELISA was used to detect the IL-6 and TNF-α levels in the serum. Real-time PCR was performed to assess the expression of FasmRNA, Fas-LmRNA, Bcl-2mRNA of the liver tissues. Western blotting was used to detect the Bax protein expression of the liver tissues. The serum IL-6 and TNF-α levels of Group B were significantly higher than the other groups (P<0.05). The expression of Fas mRNA, Fas-LmRNA, and Bax protein of the liver tissues of Group B were significantly higher than those of the other groups (P<0.05). The expression of Bcl-2 mRNA of the liver tissues of Group B was significantly lower than other groups (P<0.05). Both of XCHT and biphenyl dicarboxylate significantly decreased the serum IL-6 and TNF-α levels and FasmRNA, FasLmRNA, Bax protein expression and increased the Bcl-2 mRNA expression of the liver tissues of model mice (P<0.05). It may be through decreasing the serum IL-6 and TNF-α levels and FasmRNA, FasLmRNA, Bax protein expression and increasing the Bcl-2 mRNA expression of the liver tissues that XCHT significantly relieved the D-galactosamine -induced liver injury.     

香砂六君子汤加减方对功能性消化不良的影响及作用机制研究

目的观察香砂六君子汤加减方对功能性消化不良(FD)的影响,并探讨其作用机制。方法将120例FD患者随机分为2组,治疗组60例予香砂六君子汤治疗,对照组60例予多潘立酮联合奥美拉唑肠溶胶囊治疗。2个月后评定疗效,并检测胃肠激素、血浆P物质、胃排空率,以尼平消化不良指数(NDI)评价治疗前后胃肠功能变化。结果治疗组总有效率86.7%,高于对照组(68.3%,P0.05)。2组治疗后及停药后随访时症状指数(NDSI)及生活质量指数(NDLQI)评分均明显改善(P0.05),且治疗组改善情况明显优于对照组(P0.05)。2组治疗后血清胃动素(MTL)、生长抑素(SS)、血浆P物质测定及胃排空率均明显改善(P0.05),且治疗组改善情况明显优于对照组(P0.05)。结论香砂六君子汤加减治疗FD临床疗效确切,其发挥作用的机制可能与降低内脏高敏感,提高胃肠道动力有关。     

糖尿病合并高血压病中医辩证治疗研究

目的对应用中医辩证治疗糖尿病合并高血压病进行临床研究。方法选取2009年2月～2011年2月广东省信宜中医院门诊及住院病人,研究共观察60例病人,按随机分组原则分为治疗组和对照组。对照组：基础治疗＋西药降糖降压治疗;治疗组：基础治疗＋西药降糖降压＋中药治疗。结果治疗组30例,总有效率93.33%。对照组30例,总有效率80.00%。治疗总有效率优于对照组,有统计学意义（P〈0.05）。降糖效果和降压分析表明治疗组降糖效果和降压效果显著优于对照组。两组治疗前后均未见不良反应。结论中医辩证治疗可明显改善临床症状,在西医学指标方面,可以降低血糖、血压、血脂,能够改善患者整体状况,治疗本病安全、有效,有广泛的应用前景。     

华夏小葱制剂对脂肪肝大鼠一氧化氦、一氧化氦合酶及血管内皮生长因子的影响

目的：探讨华夏小葱制剂对大鼠脂肪肝的防治作用及其机制。方法：SD大鼠分为空白对照组，模型对照组，华夏小葱制剂低、中、高剂量组，东宝肝泰片组共6个组。空白对照组大鼠用普通饮食及普通水喂养；其他组用高脂饮食及酒精水喂养，并且每周一次行后肢皮下注射四氯化碳色拉油溶液建立大鼠脂肪肝模型。华夏小葱制剂低、中、高剂量组及东宝肝泰片组大鼠分别给予相应剂量的华夏小葱制剂或东宝肝泰片混悬液。8周后处死各组大鼠。采用全自动生化分析仪测定血浆中总胆固醇（TC）、甘油三酯（TG）含量，一氧化氮（NO），一氧化氮合酶（NOS），RT-PCR法测血管内皮生长因子（VEGF）mRNA的含量。结果：大鼠血浆TC、TG值，肝组织NO、NOS值及VEGF值各组比较，模型对照组显著高于空白对照组（P〈0．01），华夏小葱制剂低、中、高剂量组及东宝肝泰片组均显著低于模型对照组（P〈0．05或P〈0．01）。结论：华夏小葱制剂具有降低TG、TC，改善活性氮的作用，其治疗脂肪肝的机制可能与减少细胞因子损伤有关。     

中西药联合灌肠治疗溃疡性结肠炎的疗效观察

目的：观察中西药联合灌肠对溃疡性结肠炎的疗效和治疗前后免疫调节功能的变化。方法：将115例溃疡性结肠炎患者随机分为3组，分别以中药、西药和中西药联合灌肠，每晚1次，15天为1疗程。结果：中西药联合组的治愈率、总有效率、症状缓解起始时间和对IgG、C3的调节功能明显优于中药组和西药组（P＜0．05或P＜0．01）。结论：中西药联合灌肠疗法疗效显著，价格低廉，副作用少，是治疗溃疡性结肠炎较理想的方法。     

Successful treatment of spinocerebellar ataxia 6 with medicinal herbs

A case of familial spinocerebellar ataxia 6 with typical symptoms is presented. A 60-year-old Japanese female suffered from gait disturbance, ataxia and dizziness. Head magnetic resonance imaging revealed a typical atrophic image in cerebellum. Genetic tests revealed an expanded allele of 22 CAG repeats at the spinocerebellar ataxia type 6 locus. She was diagnosed with spinocerebellar ataxia 6. Her mother was also diagnosed with the same disease. A mixture of 18 medicinal herbs (modified Zhengan Xifeng Tang) was given according to the differential diagnosis based on the guidelines of traditional Chinese medicine. All of the symptoms were remarkably improved after 60 days of the herbal treatment. One year after discontinuation of the treatment, she complained of gait ataxia. She was treated with the modified Zhengan Xifeng Tang for 60 days. Gait ataxia was markedly improved by the second treatment. Fifteen months after discontinuation of the second treatment, she complained of gait ataxia again. The same remedy was given for 60 days. Gait ataxia was remarkably reduced again. The results may imply therapeutic potential of the medicinal herbs for spinocerebellar ataxia 6.