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991.
Noll BO McCluskie MJ Sniatala T Lohner A Yuill S Krieg AM Schetter C Davis HL Uhlmann E 《Biochemical pharmacology》2005,69(6):981-991
To evaluate pharmacokinetics (PK) and biodistribution, CPG 7909, a 24-mer immunostimulatory fully phosphorothioated oligodeoxynucleotide (PS-ODN), was administered by subcutaneous injection at 2, 5 and 12.5mg/kg to mice and at 9mg/kg to rats. Parent compound and metabolites were isolated from plasma and tissues and quantified by capillary gel electrophoresis with UV detection (CGE-UV) and molecular masses were determined by matrix-assisted-laser-desorption-ionization time of flight detection (MALDI-TOF). An established method for PS-ODN isolation from plasma and tissue was modified to prevent oxidation of the phosphorothioate bonds during the extraction process, significantly increasing sensitivity in the subsequent MALDI-TOF analysis. Concentrations of CPG 7909 and metabolites were highest at the injection site (>600mg/kg at 4h). Maximal concentrations in local (draining) lymph nodes (LLN), kidney and liver were 10-15% of that at the injection site. The highest total amount of PS-ODN (percentage of administered dose) was found in the liver (32% at 4h), followed closely by the injection site (23% at 4h). Only very low levels of CPG 7909 and metabolites were found in plasma and only during the first hours. Metabolites identified by MALDI-TOF were similar for both species and all analyzed tissues, although the relative amounts of the different metabolites varied with tissue and over time. Degradation of CPG 7909 in vivo occurred predominantly by 3'exonucleases with additional cleavage by endonucleases. 相似文献
992.
Atsushi Horiuchi Kazuhiro Kameoka Jun Kuwabara Yuji Watanabe Sanae Kawakami Hisamichi Tauchi Eiichi Ishii 《Pediatrics international》2012,54(5):712-714
Iliopsoas abscess (IPA) is rare in children, particularly in neonates. A male neonate was born at 38 weeks of gestation with a weight of 2915 g. On day 22 after birth, his family noticed that his right thigh was swollen. Abdominal computed tomography showed a mass extending to the right iliopsoas from the right thigh with thick septa. Puncture to the right groin yielded purulent fluid, and so a diagnosis of abscess was made. The puncture was followed by surgical drainage through a small inguinal incision, and the abscess cavity was irrigated thoroughly using normal saline. Culture of abscess fluid was positive for Streptococcus pneumoniae, so intravenous ABPC infusion was continued. The postoperative magnetic resonance imaging indicate that the IPA was derived from arthritis of the hip, and the patients received Riemenbügel for the incomplete hip dislocation. He is doing well at 2 years of age. 相似文献
993.
994.
陈华 《四川生理科学杂志》2012,34(4):160-162
目的:分析探讨在超声介入下经皮肝脏穿刺置管引流术对肝脓肿的临床治疗效果。方法:回顾性分析我院2010年1月-2012年2月期间行超声引导下穿刺置管引流术(观察组)患者的临床病例资料,并与2007年4月-2008年7月期间在我院行剖腹置管引流(对照组)治疗肝脓肿患者的病例资料进行对比研究。比较两组患者术后WBC恢复正常的时间、体温恢复正常时间、拔管时间、住院时间以及费用等,并统计两组患者临床治愈例数及并发症发生例数。结果:观察组患者术后WBC和体温恢复正常时间明显较短,平均住院时间也短于对照组,住院费用也相对较少,两组之间比较差异有显著的统计学意义(P〈0.05);观察组患者临床治愈率为100%,无一例发生并发症,对照组患者临床治愈率为82.60%,并发症发生率为26.10%,两组间有显著的统计学差异(P〈0.05)。结论:超声引导下穿刺置管引流治疗肝脓肿不仅临床效果好、并发症少,而且对患者创伤小,帮助患者缩短了住院时间,住院费用也相应减少,值得临床上推广。 相似文献
995.
目的探讨小切口联合粘贴式负压冲吸器治疗直肠肛管周围脓肿的效果。方法将我科2007年2月至2010年9月收治的362例直肠肛管周围脓肿患者随机分两组,183例(实验组)采用小切17联合粘贴式负压冲吸器治疗,179例(对照组)采用切开引流治疗,对比两种方法治疗效果。结果两组在治愈率差异无统计学意义(P〉0.05),但实验组缩短手术时间及住院时间,缩小手术切口长度,并降低术后疼痛评分,与对照组比较差异有统计学意义(P〈0.05)。结论在直肠肛管周同脓肿治疗中,小切口联合粘贴式负压冲吸器具有手术时间及住院时间短、创伤小、术后疼痛轻的特点,具有较高的临床应用价值。 相似文献
996.
目的探讨生物蛋白胶封堵术治疗高位肛瘘的临床应用。方法将我科2010年3月至2011年4月期间60例高位肛瘘,随机分为治疗组和对照组各30例。治疗组采用生物蛋白胶封堵术,对照组采用肛瘘切除术,比较两组术后创面愈合时间、创面换药疼痛、肛管压力测定。结果治疗组术后疼痛及创面愈合时间均比对照组低(P〈0.05);复发率的差异无统计学意义(P〉0.05);术后肛管静息压比较,差异有统计学意义(P〈0.05)。结论生物蛋白胶封堵术治疗高位肛瘘有较好的效果,能缩短伤口愈合时间,减轻术后换药疼痛,保护肛管静息压。 相似文献
997.
998.
超声引导下穿刺冲洗治疗乳腺脓肿的临床价值 总被引:1,自引:0,他引:1
目的评价超声引导下经皮穿刺冲洗治疗乳腺脓肿的临床价值。方法对2006年1月—2010年10月在我院超声科接受超声引导下经皮穿刺冲洗治疗的22例乳腺脓肿患者进行回顾性分析。结果 22例患者共45个乳腺脓肿,经2~5次穿刺冲洗治疗后均治愈;超声可清晰监视手术进程,未出现明显疼痛、出血等并发症。结论超声引导下经皮穿刺冲洗法治疗乳腺脓肿具有实时、安全、疗效明显、并发症少、不需住院等优点,是一种值得推广的治疗方法。 相似文献
999.
Richards AJ Hagelstein SM Patel GK Ivins NM Sweetland HM Harding KG 《International wound journal》2011,8(6):608-611
Combining silver-based dressings with negative pressure therapy after radical excision of chronically infected breast disease is a novel application of two technologies. One patient with complex, chronic, infected breast disease underwent radical excision of the affected area and was treated early with a combination of silver-based dressings and topical negative pressure therapy. The wound was then assessed sequentially using clinical measurements of wound area and depth, pain severity scores and level of exudation. It is possible to combine accepted techniques with modern dressing technologies that result in a positive outcome. In this case, the combination of a silver-based dressing with negative pressure therapy following radical excision proved safe and was well tolerated by the patient. Full epithelisation of the wound was achieved and there was no recurrence of the infection for the duration of the treatment. 相似文献
1000.
Alibhai MK Samee A Ahmed M Duffield R 《International journal of surgery case reports》2011,2(6):131-133
We report a case of a sixty year old man with a mycotic infra-renal abdominal aortic aneurysm complicated by a left psoas abscess. After treatment with parenteral antibiotics he underwent early aortic reconstruction with an in-situ prosthetic graft wrapped in an omental pedicle. Mycotic abdominal aortic aneurysms can be treated in this way despite the potential for graft infection from persisting retroperitoneal sepsis. 相似文献