全文获取类型
收费全文 | 6634篇 |
免费 | 407篇 |
国内免费 | 137篇 |
专业分类
耳鼻咽喉 | 216篇 |
儿科学 | 260篇 |
妇产科学 | 117篇 |
基础医学 | 416篇 |
口腔科学 | 140篇 |
临床医学 | 992篇 |
内科学 | 1119篇 |
皮肤病学 | 210篇 |
神经病学 | 327篇 |
特种医学 | 364篇 |
外科学 | 1179篇 |
综合类 | 766篇 |
现状与发展 | 2篇 |
预防医学 | 276篇 |
眼科学 | 90篇 |
药学 | 372篇 |
4篇 | |
中国医学 | 177篇 |
肿瘤学 | 151篇 |
出版年
2024年 | 19篇 |
2023年 | 108篇 |
2022年 | 251篇 |
2021年 | 307篇 |
2020年 | 228篇 |
2019年 | 238篇 |
2018年 | 193篇 |
2017年 | 204篇 |
2016年 | 187篇 |
2015年 | 210篇 |
2014年 | 424篇 |
2013年 | 482篇 |
2012年 | 359篇 |
2011年 | 389篇 |
2010年 | 338篇 |
2009年 | 301篇 |
2008年 | 307篇 |
2007年 | 310篇 |
2006年 | 264篇 |
2005年 | 242篇 |
2004年 | 202篇 |
2003年 | 181篇 |
2002年 | 124篇 |
2001年 | 120篇 |
2000年 | 119篇 |
1999年 | 87篇 |
1998年 | 93篇 |
1997年 | 81篇 |
1996年 | 83篇 |
1995年 | 70篇 |
1994年 | 61篇 |
1993年 | 56篇 |
1992年 | 49篇 |
1991年 | 50篇 |
1990年 | 43篇 |
1989年 | 44篇 |
1988年 | 37篇 |
1987年 | 38篇 |
1986年 | 52篇 |
1985年 | 43篇 |
1984年 | 37篇 |
1983年 | 25篇 |
1982年 | 31篇 |
1981年 | 26篇 |
1980年 | 10篇 |
1979年 | 11篇 |
1978年 | 16篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1974年 | 4篇 |
排序方式: 共有7178条查询结果,搜索用时 31 毫秒
111.
J. D. Jensen J. K. Madsen L. W. Jensen 《European journal of clinical pharmacology》1996,50(3):171-177
Objective: The purpose of the study was to investigate the effect of route of administration of erythropoietin (EPO) on the dose requirement
in dialysis patients after intravenous (IV) and subcutaneous (SC) therapy.
Methods:
The study was performed as a single centre, prospective, open, combined parallel and cross-over study of 50 dialysis patients,
consecutively randomised to IV or SC treatment with EPO. The initial dose was 40 U⋅kg−1 3-times weekly, adjusted to increase haemoglobin (Hgb) from a median 5.3 mmol⋅l−1 to a target of haemoglobin 6.5–7.5 mmol⋅l−1. After reaching the target level, the haemoglobin was maintained for 4 months (Period 1). Then IV and SC treatment was switched
for a further 4 months (Period 2). The study included high risk patients. The adjustment period was completed by 38 patients,
Period one by 32 patients (IV/SC = 15/17; male/female = 19/13; age = 54 (24– 71) y), and Period two by 22 patients.
Results:
No significant difference was found between the two groups in the reticulocyte response, the rate of Hgb increase (IV 0.7
versus SC 0.5, mmol⋅l−1⋅ month−1), time to reach target level (IV 43 versus SC 60 days), or total EPO dose per increase in haemoglobin to target level (IV
663 versus SC 946 (U⋅kg−1) per (mmol Hgb⋅l−1). The overall median maintenance dose during the last month of the two four month periods was 105 (range IV 51–336) U⋅kg−1⋅w−1 and SC 104 (range 21–321) U⋅kg−1⋅w−1. Trough serum EPO levels were significantly higher during SC treatment. The blood pressure did not change significantly from
the base level after either route of administration; start 133/80 versus 143/80 mmHg, target 127/78 versus 154/85 mmHg, and
maintenance period 140/84 versus 142/85 mmHg. Thus, three-times weekly IV or SC EPO did not differ significantly in efficacy
or in the effect on blood pressure in dialysis patients.
Received: 13 June 1995/Accepted in revised form: 30 October 1995 相似文献
112.
目的探讨细菌性肝脓肿(pyogenic liver abscess,PLA)的发病因素及治疗方法。方法回顾性分析我院从1990年~2006年收治的101例PLA患者临床资料。结果33例(32.67%)合并糖尿病(DM),19例(18.8%)属胆源性,34例(33.66%)为隐源性;穿刺引流45例(44.55%),手术引流13例(12.87%),内科治疗43例(42.57%)。结论目前PLA发病因素已发生改变,主要由DM合并感染及隐源性引起,胆源性PLA亦占重要地位;疗法选择根据患者的情况以及脓肿的情况而异。 相似文献
113.
114.
115.
116.
117.
Cristiana Boldrini 《Radiology Case Reports》2023,18(2):550
Idiopathic granulomatous mastitis (IGM) is a rare inflammatory condition of the breast. IGM is a benign condition, and is more typical in women of child-bearing age, with a recent history of pregnancy and breast feeding. Its clinical presentation can mimic inflammatory breast cancer or breast abscess. The etiology of IGM is not well defined, but proposed to be a localized immune reaction to the breast tissue without the presence of an underlying infectious condition.Here we report a case of a healthy 35-year-old female, with no story of pregnancy and lactation, who presented with sudden left breast lump, swelling and pain. She underwent first diagnostic ultrasound of the affected breast, then breast MR imaging was performed. A biopsy of the lesion was obtained, which revealed chronic granulomatous inflammation, confirming the diagnosis of GM. Furthermore, the patient was found to have had hyperprolactinemia secondary to a prolactinoma of the pituitary gland (PitNET) many years before, during her 20s, for which she had been treated with surgery. 相似文献
118.
Tuberculosis is caused by Mycobacterium tuberculosis, a slow-growing aerobic bacillus. The primary site of infections can be in the lungs, mediastinum lymph nodes, mesentery, gastrointestinal tract, genitourinary system, or any other viscera. We described a case of a 52-year-old Indonesian female who presented weakness in upper and lower extremities with low back pain and stiffness of the muscle since 4 months ago and getting worse over 1 week. She has no history of pulmonary tuberculosis. Then the patient underwent a laboratory examination, chest X-ray, vertebrae X-ray, and MRI examination for further evaluation. Both examinations revealed tuberculous spondylitis with epidural abscess and intramedullary tuberculoma. The patient was administered an antituberculosis drug therapy, and the surgery was scheduled after three months of treatment. 相似文献
119.
目的 比较非肥胖型与肥胖型非酒精性脂肪性肝病(NAFLD)患者代谢特征和肝脂肪变程度差异。方法 2015年1月~2021年6月我院诊治NAFLD患者274例,根据体质指数(BMI)=25 kg/m2,将其分为非肥胖型66例和肥胖型208例。计算胰岛素抵抗指数(HOMA-IR),行磁共振仪检查,应用仪器自带软件计算肝脏脂肪含量(LFC)和腹部皮下脂肪厚度(ASFT),使用FibroTouch测量肝脏受控衰减参数(CAP),使用多普勒超声诊断仪检测颈动脉内膜中层厚度(CIMT),将肝脂肪变分为Ⅰ级、Ⅱ级和Ⅲ级。结果 非肥胖型NAFLD患者BMI为(23.4±1.4)kg/m2、血清丙氨酸氨基转移酶水平为24.2(19.6,35.8)U/L,天冬氨酸氨基转移水平为25.0(18.7,32.3)U/L,甘油三酯为(1.9±0.4)mmol/L,高密度脂蛋白为(1.3±0.4)mmol/L,空腹血糖为(5.0±0.7)mmol/L,空腹胰岛素为7.0(4.8,9.4)μU/mL,HOMA-IR为1.6(1.1,2.3),尿酸为376.5(294.3,4... 相似文献
120.
目的:对康复新液局部治疗急性牙周脓肿的临床疗效进行分析.方法:选取2019年9月至2020年9月期间我院收治的130例急性牙周脓肿患者,根据数字分组法为对照组与实验组(n=65).所有患者进行相同的常规治疗后,对照组患者使用过氧化氢与生理盐水局部冲洗、含漱,实验组患者使用康复新液局部冲洗、含漱,1 M后比较治疗效果.结... 相似文献