A Short Review on the Phase Structures,Oxidation Kinetics,and Mechanical Properties of Complex Ti-Al Alloys

This paper reviews the phase structures and oxidation kinetics of complex Ti-Al alloys at oxidation temperatures in the range of 600–1000 °C. The mass gain and parabolic rate constants of the alloys under isothermal exposure at 100 h (or equivalent to cyclic exposure for 300 cycles) is compared. Of the alloying elements investigated, Si appeared to be the most effective in improving the oxidation resistance of Ti-Al alloys at high temperatures. The effect of alloying elements on the mechanical properties of Ti-Al alloys is also discussed. Significant improvement of the mechanical properties of Ti-Al alloys by element additions has been observed through the formation of new phases, grain refinement, and solid solution strengthening.     

Thermal Conductivity of Ordered Porous Structures Coupling Gas and Solid Phases: A Molecular Dynamics Study

Heat transfer in a porous solid−gas mixture system is an important process for many industrial applications. Optimization design of heat insulation material is very important in many fields such as pipe insulation, thermal protection of spacecraft, and building insulation. Understanding the micro-mechanism of the solid−gas coupling effect is necessary for the design of insulation material. The prediction of thermal conductivity is difficult for some kinds of porous materials due to the coupling impact of solid and gas. In this study, the Grand Canonical Monte Carlo method (GCMC) and molecular dynamics simulation (MD) are used to investigate the thermal conductivity for the ordered porous structures of intersecting square rods. The effect of gas concentration (pressure) and solid−gas interaction on thermal conductivity is revealed. The simulation results show that for different framework structures the pressure effect on thermal conductivity presents an inconsistent mode which is different from previous studies. Under the same pressure, the thermal conductivity is barely changed for different interactions between gas and solid phases. This study provides the feasibility for the direct calculation of thermal conductivity for porous structures coupling gas and solid phases using molecular dynamics simulation. The heat transfer in porous structures containing gas could be understood on a fundamental level.     

Analysis of the Influence of Fatigue Strength of Prototype Under Ballast Mats (UBMs) on the Effectiveness of Protection against Vibration Caused by Railway Traffic

The present paper focuses on laboratory tests of fatigue strength of prototype under ballast mats (UBMs), carried out according to the procedure described in the new European standard EN 17282, which was released in October 2020. The mineral wool-based mat revealed significant differences in the values of static and dynamic characteristics, measured before and after the fatigue tests. The elastomeric mats based on recycled materials (SBR granulate and fibers) turned out to have had sufficient durability and effectiveness of protection against vibration caused by railway traffic. The values of static and dynamic bedding moduli, determined before and after the fatigue tests, were used to develop a viscoelastic rheological model of the vibration isolator with the use of fractional derivatives. Using this original model of the ballasted track system with four degrees of freedom, a significant influence of cyclic loading on the level of vibration suppression (insertion loss factor) was demonstrated. The analytical model confirmed that the mats with variations of bedding moduli exceeding 10% should not be used as resilient elements.     

Time-Dependent Response of a Recycled C&D Material-Geotextile Interface under Direct Shear Mode

Geosynthetic-reinforced soil structures have been used extensively in recent decades due to their significant advantages over more conventional earth retaining structures, including the cost-effectiveness, reduced construction time, and possibility of using locally-available lower quality soils and/or waste materials, such as recycled construction and demolition (C&D) wastes. The time-dependent shear behaviour at the interfaces between the geosynthetic and the backfill is an important factor affecting the overall long-term performance of such structures, and thereby should be properly understood. In this study, an innovative multistage direct shear test procedure is introduced to characterise the time-dependent response of the interface between a high-strength geotextile and a recycled C&D material. After a prescribed shear displacement is reached, the shear box is kept stationary for a specific period of time, after which the test proceeds again, at a constant displacement rate, until the peak and large-displacement shear strengths are mobilised. The shear stress-shear displacement curves from the proposed multistage tests exhibited a progressive decrease in shear stress with time (stress relaxation) during the period in which the shear box was restrained from any movement, which was more pronounced under lower normal stress values. Regardless of the prior interface shear displacement and duration of the stress relaxation stage, the peak and residual shear strength parameters of the C&D material-geotextile interface remained similar to those obtained from the conventional (benchmark) tests carried out under constant displacement rate.     

Potential Dual Role of West Nile Virus NS2B in Orchestrating NS3 Enzymatic Activity in Viral Replication

West Nile virus (WNV) nonstructural protein 3 (NS3) harbors the viral triphosphatase and helicase for viral RNA synthesis and, together with NS2B, constitutes the protease responsible for polyprotein processing. NS3 is a soluble protein, but it is localized to specialized compartments at the rough endoplasmic reticulum (RER), where its enzymatic functions are essential for virus replication. However, the mechanistic details behind the recruitment of NS3 from the cytoplasm to the RER have not yet been fully elucidated. In this study, we employed immunofluorescence and biochemical assays to demonstrate that NS3, when expressed individually and when cleaved from the viral polyprotein, is localized exclusively to the cytoplasm. Furthermore, NS3 appeared to be peripherally recruited to the RER and proteolytically active when NS2B was provided in trans. Thus, we provide evidence for a potential additional role for NS2B in not only serving as the cofactor for the NS3 protease, but also in recruiting NS3 from the cytoplasm to the RER for proper enzymatic activity. Results from our study suggest that targeting the interaction between NS2B and NS3 in disrupting the NS3 ER localization may be an attractive avenue for antiviral drug discovery.     

Synthesis,Polymorphism and Thermal Decomposition Process of (n-C4H9)4NRE(BH4)4 for RE = Ho,Tm and Yb

In total, three novel organic derivatives of lanthanide borohydrides, n-But₄NRE(BH₄)₄ (TBAREB), RE = Ho, Tm, Yb, have been prepared utilizing mechanochemical synthesis and purified via solvent extraction. Studies by single crystal and powder X-ray diffraction (SC-XRD and PXRD) revealed that they crystalize in two polymorphic forms, α- and β-TBAREB, adopting monoclinic (P2₁/c) and orthorhombic (Pnna) unit cells, previously found in TBAYB and TBAScB, respectively. Thermal decomposition of these compounds has been investigated using thermogravimetric analysis and differential scanning calorimetry (TGA/DSC) measurements, along with the analysis of the gaseous products with mass spectrometry (MS) and with analysis of the solid decomposition products with PXRD. TBAHoB and TBAYbB melt around 75 °C, which renders them new ionic liquids with relatively low melting points among borohydrides.     

A sense of place,many times over - pattern formation and evolution of repetitive morphological structures

Fifty years ago, Lewis Wolpert introduced the concept of “positional information” to explain how patterns form in a multicellular embryonic field. Using morphogen gradients, whose continuous distributions of positional values are discretized via thresholds into distinct cellular states, he provided, at the theoretical level, an elegant solution to the “French Flag problem.” In the intervening years, many experimental studies have lent support to Wolpert's ideas. However, the embryonic patterning of highly repetitive morphological structures, as often occurring in nature, can reveal limitations in the strict implementation of his initial theory, given the number of distinct threshold values that would have to be specified. Here, we review how positional information is complemented to circumvent these inadequacies, to accommodate tissue growth and pattern periodicity. In particular, we focus on functional anatomical assemblies composed of such structures, like the vertebrate spine or tetrapod digits, where the resulting segmented architecture is intrinsically linked to periodic pattern formation and unidirectional growth. These systems integrate positional information and growth with additional patterning cues that, we suggest, increase robustness and evolvability. We discuss different experimental and theoretical models to study such patterning systems, and how the underlying processes are modulated over evolutionary timescales to enable morphological diversification.     

Mechanical Behaviour of Aluminium-Timber Composite Connections with Screws and Toothed Plates

This paper presents an investigation of the load-slip behaviour of aluminium-timber composite connections. Toothed plates with bolts are often used for connecting timber structural members with steel structural members. In this paper, toothed plates (C2-50/M10G, C2-50/M12G or C11-50/M12) have been used as reinforcement in aluminium-timber screwed connections for the first time. The push-out test specimens consisted of laminated veneer lumber slabs, aluminium alloy beams, and hexagon head wood screws (10 mm × 80 mm and 12 mm × 80 mm). Of the specimens, 12 additionally had toothed plates as reinforcement, while 8 had no reinforcement. The load carrying-capacity, the mode of failure and the load-slip response of the strengthened and non-strengthened screwed connections were investigated. The use of toothed plate connectors was found to be effective in increasing the strength of aluminium-timber composite connections and ineffective in improving their stiffness. The examined stiffness and strength of the connections can be used in the design and numerical modelling of aluminium-timber composite beams with reinforced screwed connections.     

Comparison of Failure for Thin-Walled Composite Columns

The novelty of this paper, in relation to other thematically similar research papers, is the comparison of the failure phenomenon on two composite profiles with different cross-sections, using known experimental techniques and advanced numerical models of composite material failure. This paper presents an analysis of the failure of thin-walled structures made of composite materials with top-hat and channel cross-sections. Both experimental investigations and numerical simulations using the finite element method (FEM) are applied in this paper. Tests were conducted on thin-walled short columns manufactured of carbon fiber reinforced polymer (CFRP) material. The experimental specimens were made using the autoclave technique and thus showed very good strength properties, low porosity and high surface smoothness. Tests were carried out in axial compression of composite profiles over the full range of loading—up to total failure. During the experimental study, the post-buckling equilibrium paths were registered, with the simultaneous use of a Zwick Z100 universal testing machine (UTM) and equipment for measuring acoustic emission signals. Numerical simulations used composite material damage models such as progressive failure analysis (PFA) and cohesive zone model (CZM). The analysis of the behavior of thin-walled structures subjected to axial compression allowed the evaluation of stability with an in-depth assessment of the failure of the composite material. A significant effect of the research was, among others, determination of the phenomenon of damage initiation, delamination and loss of load-carrying capacity. The obtained results show the high qualitative and quantitative agreement of the failure phenomenon. The dominant form of failure occurred at the end sections of the composite columns. The delamination phenomenon was observed mainly on the outer flanges of the structure.     

A prospective multicentre screening study on multidrug-resistant organisms in intensive care units in the Dutch–German cross-border region, 2017 to 2018: the importance of healthcare structures

BackgroundAntimicrobial resistance poses a risk for healthcare, both in the community and hospitals. The spread of multidrug-resistant organisms (MDROs) occurs mostly on a local and regional level, following movement of patients, but also occurs across national borders.AimThe aim of this observational study was to determine the prevalence of MDROs in a European cross-border region to understand differences and improve infection prevention based on real-time routine data and workflows.MethodsBetween September 2017 and June 2018, 23 hospitals in the Dutch (NL)–German (DE) cross-border region (BR) participated in the study. During 8 consecutive weeks, patients were screened upon admission to intensive care units (ICUs) for nasal carriage of meticillin-resistant Staphylococcus aureus (MRSA) and rectal carriage of vancomycin-resistant Enterococcus faecium/E. faecalis (VRE), third-generation cephalosporin-resistant Enterobacteriaceae (3GCRE) and carbapenem-resistant Enterobacteriaceae (CRE). All samples were processed in the associated laboratories.ResultsA total of 3,365 patients were screened (median age: 68 years (IQR: 57–77); male/female ratio: 59.7/40.3; NL-BR: n = 1,202; DE-BR: n = 2,163). Median screening compliance was 60.4% (NL-BR: 56.9%; DE-BR: 62.9%). MDRO prevalence was higher in DE-BR than in NL-BR, namely 1.7% vs 0.6% for MRSA (p = 0.006), 2.7% vs 0.1% for VRE (p < 0.001) and 6.6% vs 3.6% for 3GCRE (p < 0.001), whereas CRE prevalence was comparable (0.2% in DE-BR vs 0.0% in NL-BR ICUs).ConclusionsThis first prospective multicentre screening study in a European cross-border region shows high heterogenicity in MDRO carriage prevalence in NL-BR and DE-BR ICUs. This indicates that the prevalence is probably influenced by the different healthcare structures.