海军特种兵海上训练卫勤保障特点及训练伤预防

目的:探讨海军特种兵大队海上训练伤预防方法。方法:结合海军特种兵大队海上训练卫勤保障特点和要求,通过加强组织领导、精心做好各项准备、逐步完善防治救护措施等手段进行卫勤保障。结果:通过对海军特种兵大队海上训练卫勤保障,使参训官兵训练伤控制在0．13％以下,海上训练取得明显实效。结论:经过不断探索并加以实践,提高了卫勤保障能力,减少了海上训练伤。     

A Noninterventional,Observational, European Post-Authorization Safety Study of Patients With Relapsed/Refractory Multiple Myeloma Treated With Lenalidomide

IntroductionLenalidomide plus dexamethasone is effective and well tolerated in relapsed/refractory multiple myeloma (RRMM). In this observational, noninterventional European post-authorization safety study, the safety profile of lenalidomide plus dexamethasone was investigated and compared with that of other agents in the treatment of RRMM in a real-world setting.Patients and MethodsPatients had received ≥ 1 prior antimyeloma therapy; prior lenalidomide was excluded. Treatment was per investigator’s routine practice. Adverse events were analyzed by incidence rates per 100 person-years to account for differences in observation length and treatment duration.ResultsIn total, 2150 patients initiated lenalidomide, and 1479 initiated any other antimyeloma therapy, predominately bortezomib (80.3%), which was primarily administered intravenously (74.3%). The incidence rate of neuropathy was lower with lenalidomide (10.5) than with bortezomib (78.9) or thalidomide (38.7). Lenalidomide also had a lower incidence rate of infections (68.7) versus bortezomib (95.9) and thalidomide (76.0). Conversely, the incidence rate of neutropenia was higher with lenalidomide (38.0) than with bortezomib (18.2) or thalidomide (25.7). The incidence rates of thrombocytopenia were 24.4, 40.4, and 14.4 with lenalidomide, bortezomib, and thalidomide, respectively.ConclusionNo new safety signals for lenalidomide were identified in this study, which is the largest prospective real-world European study of lenalidomide in patients with RRMM to date. These results confirm that the safety profile of lenalidomide plus dexamethasone in RRMM in a real-world setting is comparable to that reported in clinical trials.     

特岗轮训在护士层级进阶培训中的实践与成效

目的:探讨特殊岗位轮训在护士层级进阶培训中的效果.方法:实验组采用特殊岗位轮训,对照组接受常规培训,比较2组护士培训前后的床边综合能力和岗位胜任能力.结果:实验组操作技能(92.83±1.88)和床边综合能力(91.57±1.66)高于对照组(91.54±2.02、89.78±1.92),差异有统计学意义(P<0.05...     

免疫比浊法检测血清游离轻链的方法学评价

目的对Beckman Immage 800全自动特种蛋白分析仪检测血清游离κ、λ轻链(sFLC)进行方法学评价。方法通过Beckman Immage 800定量测定sFLC,探讨其精密度、正确度、分析测量范围、干扰和携带污染率,同时对其参考区间进行验证。结果κFLC低、高值批内精密度的变异系数(CV)分别为7.84%、2.95%,批间精密度的CV分别为7.38%、5.57%;λFLC低、高值批内精密度(CV)分别为4.59%、3.94%,批间精密度CV分别为3.97%、2.01%;测定κFLC、λFLC定值质控血清与靶值的偏倚小于5%;κFLC、λFLC分析测量范围分别为10.8~128.0 mg/L、10.1~121.0 mg/L时,a值在0.95~1.05,r2≥0.98;κFLC、λFLC携带污染率分别为0.411%、0.216%;干扰试验结果显示游离胆红素≤342.0μmol/L、结合胆红素≤342.0μmol/L、血红蛋白≤5g/L和乳糜≤2 400浊度时,对sFLC结果无明显影响;40例健康体检者中有1例κFLC测定结果超出厂家推荐的参考区间,40例λFLC检测值均在厂家推荐的参考区间内。结论 Beckman Immage 800全自动特种蛋白分析仪检测sFLC的主要分析性能符合质量目标的要求,能够为临床提供科学、准确的诊疗依据。     

设立军人诊区提高为部队服务质量

本文总结福州总医院多年探索新的为部队服务保障模式的工作经验。在为部队服务方面有许多新举措,尤其是在新落成的新门诊大楼特设军人诊区,采取一站式服务,配以先进的设施,安排服务热情、业务精干、责任心强的医务人员到军人诊区工作。通过一年多的实践表明：军人门诊最大限度提高军人门诊就医效率,军队人员就医质量得到了充分的保证,同时也解决了军地患者在同一诊区就诊矛盾,显著地改善了军人门诊就医的流程和环境,提高了服务保障水平。     

Adolescents with chronic hepatitis C might be good candidates for direct‐acting antiviral therapy

Three Japanese adolescents with chronic hepatitis C were treated by direct‐acting antivirals (DAAs). No adverse events or laboratory abnormalities were observed during and after DAA therapy, and a sustained virological response was achieved in all cases. The emotional functioning of the patients and their mothers were improved after DAA therapy.     

煤矿井下特种工心理健康与应对方式的关系

目的:了解煤矿井下特种作业员工的应对方式对心理健康状况的影响。方法:选取了某煤炭企业集团所属10个矿区井下作业1013人为被试,使用症状自评量表(SCL-90)以及简易应对方式量表(SCSQ)进行测量。结果:(1)井下特种作业员工SCL-90总分及躯体化、强迫、焦虑以及精神病性因子得分均显著高于全国常模,差异具有统计学意义(t=3.53,5.28,7.53,2.19,2.82;P0.05)。人际关系得分低于全国常模,其中人际关系因子得分具有显著差异(t=-6.70,-0.75;P0.05);(2)积极应对方式和消极应对方式使用状况均低于全国常模,差异有显著性(t=-2.12,-3.38;P0.05);(3)积极应对方式与SCL-90总分及各因子分呈显著负相关,消极应对方式与SCL-90总分及各因子分呈显著正相关,差异均有统计学意义(P0.01)。结论:井下特种作业员工心理健康水平显著差于全国一般人群;压力状态下,使用应对方式的情况显著少于全国一般人群;积极应对方式和消极应对方式对特种作业员工的心理健康状况有不同的影响。     

Development of clinical genetics in Asia

This Special Issue on Clinical Genetics in Asia highlights a collection of articles showing the growth, development, and current status of clinical genetics in Asia. In this Introduction, the Guest Editors share on the themes of this issue to provide useful insights into the rapid growth of genomics and clinical genetics in this region. The contents of this Issue cover a range of topics from the history and development of clinical genetics in Asia to studies on disorders with clinical significance or phenotype differences in the Asian populations to the status of precision medicine. The goal is to provide a glimpse of how significantly the field of genetics in Asia has developed in recent years with the aspiration that this can serve as a catalyst to increase international collaboration and cooperation in combating genetic diseases. We hope that this issue shows Asia's readiness and willingness to be a part of more international conversations about genetics in future.     

PBL教学法在消化内科护理大专实习生教学查房中的应用

[目的]探讨PBL教学法在消化内科护理大专实习生教学查房中的应用.[方法]将60名消化内科护理大专实习生随机分为对照组和观察组,对照组采取传统教学模式,观察组采取PBL教学法进行教学查房.比较护生对教学查房后两种教学方法的教学效果评价.[结果]观察组护生教学查房后对教学方法的评价优于对照组.[结论]消化内科护理大专实习生教学查房中应用PBL教学法可提高教学效果,有助于培养护生的独立思考和知识整合能力,有利于培养护生的沟通能力,增强护生的合作精神.