关于河南中医学院设置健康保险专业的思考

目的：探讨河南中医学院设置健康保险专业的论证。方法：从我国健康保险业的发展实际出发,集中分析河南中医学院设置健康保险专业的必要性,论证了河南中医学院在师资、设施、生源与就业等方面的可行性,以培养目标、课程设置和实习基地建设为轴线,提出了设置健康保险专业的建议。结果与结论：河南中医学院设置健康保险专业有必要、有可行性、有优势。     

精密输液器的使用对高压氧治疗中气管切开插管患者气道湿化的影响

目的：探讨精密输液器的使用对高压氧治疗中气管切开插管患者气道湿化的影响。方法：76例气管切开术后患者均采用精密输液器进行气道湿化,观察其治疗前和治疗第1、3、5、10天的刺激性咳嗽、痰阻次数、吸痰量、吸痰次数等指标。结果：至治疗后10天,患者的刺激性咳嗽、痰阻次数、吸痰量、吸痰次数等指标均显著改善（P〈0.01）,痰液粘稠度亦显著降低（P〈0.05）。结论：使用精密输液器能达到理想的湿化效果,降低了患者的高气道反应,减少了对气道的刺激,并且操作简单、安全可靠,值得临床推广应用。     

3岁听障与健听儿童开放式单音节测试结果比较分析

目的比较3岁听障儿童与同龄健听儿童开放式单音节测试结果,为提高康复教学效果提供依据。方法选取3岁听障儿童与同龄健听儿童各30例,采用言语听觉反应评估（evaluation of auditory response to speech ,EARS）中的开放式单音节分别对两组儿童进行测试,比较其结果。结果两组儿童各测试项得分高低排序均为声调得分＞韵母得分＞声母得分＞字得分,且两两之间的差异均有统计学意义（P＜0．01）;3岁听障儿童的声母、韵母和字得分均显著低于同龄健听儿童（ P＜0．001）。错误分析表明两组儿童中舌尖后音、边音的正确率均最低;健听儿童的双唇音、唇齿音、鼻音、塞音正确率最高,而听障儿童的舌根音正确率最高。听障儿童各发音部位及发音方法的声母、鼻韵母的正确率均显著低于健听儿童（P＜0．05）。结论3岁听障儿童在开放式单音节测试中的声母、韵母和字得分差于同龄健听儿童,且以舌尖后音、边音最为突出,这可能与听障儿童听力状况带来的输入性语言信息不足和听觉干预起始年龄有关。     

输液调节器控制腰大池持续引流治疗颅内感染50例

目的：探讨持续腰大池应用输液调节器控制引流治疗开颅术后颅内感染及切口愈合不良脑脊液漏的疗效。方法回顾性分析2008年10月-2013年10月经持续腰大池加输液调节器控制脑脊液引流治疗的50例术后颅内感染及脑脊液漏患者的临床资料。结果50例患者中颅脑外伤开颅去骨瓣减压术后切口愈合不良脑脊液漏20例,高血压脑出血去骨瓣减压术后皮瓣下积液伴脑脊液漏20例,所有患者均痊愈出院。结论颅内感染及脑脊液漏应用持续腰大池加输液调节器控制引流脑脊液,配合全身应用敏感抗生素是治疗术后手术切口愈合不良脑脊液漏及颅内感染的一种安全、良好的方法。     

普那菊苣高产配套栽培技术研究

用田间试验和定量分析的方法研究普那菊苣高产与主要栽培因子之间的数量关系,建立有关数学模型并作了增产效应分析。在试验条件下,普那菊苣产量要达到83390.38kg/ha,种植密度应为64253窝/ha,配施N肥为331.05kg/ha,K肥为58.8kg/ha,P肥为256.05kg/a,达到普那菊苣高产目的。     

Immunogenicity and safety of a quadrivalent inactivated influenza vaccine compared with two trivalent inactivated influenza vaccines containing alternate B strains in adults: A phase 3, randomized noninferiority study

BackgroundVaccination is the most effective means of influenza prevention. Efficacy of trivalent vaccines may be enhanced by including both B strain lineages. This phase 3, double-blind study assessed the immunogenicity and safety/tolerability of a quadrivalent inactivated influenza vaccine (IIV4) versus the United States (US)-licensed 2014–2015 trivalent inactivated influenza vaccine (IIV3-Yamagata [IIV3-YAM]; Afluria) and IIV3 containing the alternate Victoria B strain (IIV3-VIC) in adults ≥18 years.MethodsParticipants (n = 3484) were randomized 2:1:1 and stratified by age to receive IIV4 (n = 1741), IIV3-YAM (n = 871), or IIV3-VIC (n = 872). The primary objective was to demonstrate noninferiority of the immunological response to IIV4 versus IIV3-YAM and IIV3-VIC. Noninferiority was assessed by hemagglutination inhibition geometric mean titer (GMT) ratio (IIV3/IIV4; upper bound of two-sided 95% confidence interval [CI] ≤ 1.5) and seroconversion rate (SCR) difference (IIV3 – IIV4; upper bound of two-sided 95% CI ≤ 10%) for vaccine strains. Solicited local and systemic adverse events (AEs) were assessed for 7 days postvaccination, AEs recorded for 28 days postvaccination, and serious AEs for 6 months postvaccination.ResultsIIV4 elicited a noninferior immune response for matched strains, and superior response for unmatched B strains not contained in IIV3 comparators. Adjusted GMT ratios (95% CI) for A/H1N1, A/H3N2, B/YAM, and B/VIC strains were 0.93 (0.88, 0.99), 0.93 (0.88, 0.98), 0.87 (IIV3-YAM; 0.82, 0.93), and 0.95 (IIV3-VIC; 0.88, 1.03), respectively. Corresponding values for SCR differences (95% CI) were −1.1 (−4.5, 2.3), −1.7 (−5.0, 1.7), −3.2 (IIV3-YAM; −7.4, 0.9), and −1.6 (IIV3-VIC; −5.8, 2.5). AEs were generally mild and experienced by 52.9% of participants. Serious AEs were reported with a slightly higher frequency with IIV4 (2.3%) versus IIV3-YAM (1.6%) and IIV3-VIC (1.5%).ConclusionsIIV4 demonstrated immunological noninferiority to the US-licensed IIV3, and superiority for unmatched B strains not contained in IIV3 comparators. Safety/tolerability profiles were similar across vaccine groups.Funding: Seqirus; Clinicaltrials.gov: NCT02214225.     

Predicting RNA secondary structure based on the class information and Hopfield network

One of the models for RNA secondary structure prediction is to view it as maximum independent set problem, which can be approximately solved by Hopfield network. However, when predicting native molecules, the model is not always accurate and the heuristic method of Hopfield network is not always stable. It is because that the class information is lost and the accuracy is not determined by the number of base pairs only. Secondary structures of non-coding RNAs are believed conservative on the same class. However, software and web servers nowadays for RNA secondary structure prediction do not consider the class information. In this paper, we involve class information in the initialization of Hopfield network. When the initialization is improved, the promising experimental result shows the efficacy and superiority of our proposed methods.     

基于改进变分水平集法提取超声图像乳腺肿瘤边缘

目的研究准确提取超声图像乳腺肿瘤边缘的算法。方法在变分水平集方法中提出一种新型能量函数—全局—局部能量函数,通过加强图像的局部信息,实现超声图像乳腺肿瘤边缘的准确提取。结果对仿真超声图像的实验表明,本方法比全局最优化的Chan-Vese方法能更准确区分目标和背景。对103例超声乳腺肿瘤图像的实验表明,本方法无需任何预处理步骤即可准确提取肿瘤边缘。结论本方法有望实现超声图像乳腺肿瘤边缘的快速、准确提取。