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991.
应用腹蛇抗栓酶-3治疗94例糖尿病患者并发的脑血栓形成、高脂血症、动脉硬化、神经病变和心绞痛取得较好的疗效。脑血栓形成急性期采用冲击疗法,瘫痪肢体功能恢复迅速、合并神经病变者,治疗后症状消失、神经功能改善。TG、TC、β-脂蛋白水平和TC/HDL比值均降低(P<0.01),HDL水平上升(P<0.01),对比治疗前后血6-Keto-PGF_(1α)、TXB_2和纤维结合素FN的水平改善,具有统计学意义(P<0.01)。 相似文献
992.
目的 探讨HCMV感染是否引起大鼠和家兔胃肠组织损伤。方法 将人巨细胞病毒(Human Cyto—megalovirus,HCMV)AD168毒株静脉接种大鼠和新西兰兔,大鼠90d、兔30d后,检查动物胃、肠组织的病理变化,用免疫组化方法和原位杂交方法检查组织中的病毒抗原和DNA片段。结果 接种病毒之部分动物出现食量减少、粘液性大便,胃粘膜组织可见淋巴细胞浸润,肠粘膜变性坏死,甚至有穿孔灶;在粘膜细胞中查到病毒抗原或DNA片段。结论 HCMV感染可以侵犯动物胃肠组织并引起该组织病理损伤。 相似文献
993.
D. Agnusdei G. Crepaldi G. Isaia G. Mazzuoli S. Ortolani M. Passeri L. Bufalino C. Gennari 《Calcified tissue international》1997,61(2):142-147
One hundred ninety-eight postmenopausal women (aged 50–65 years) with vertebral bone density (VBD) 1 SD below the mean value
for normal, age-matched, postmenopausal subjects were enrolled in six Italian centers and 134 completed 2 years of treatment.
All subjects were randomly allocated to a 2-year treatment with oral ipriflavone (200 mg t.i.d.) or a matching placebo, according
to a double-blind, parallel group design. All patients also received an oral daily calcium supplement of 1 g as calcium carbonate.
VBD and markers of bone turnover were measured at baseline, and every 6 months. A complete routine analysis of liver and kidney
functions along with hematological parameters were measured before and at the end of treatment period. The valid completers
analysis showed a significant increase of VBD in ipriflavone-treated women with average percent changes of +1.4 after 1 year,
and +1% at the end of treatment period (P < 0.05). The placebo group presented a significant decrease of VBD after 2 years of treatment (P < 0.05). The difference between treatments was significant (P < 0.01). The intention to treat analysis confirmed the significant decrease of VBD in the placebo group, with no changes
in ipriflavone-treated women. Skeletal ALP significantly decreased in ipriflavone-treated women (P < 0.05). Serum BGP and urine HOP/Cr showed a significant decrease only in ipriflavone-treated women, suggesting an inhibitory
effect on bone turnover rate. Adverse reactions, mainly gastrointestinal, occurred to a similar extent in the two treatment
groups. The evaluation of patients' compliance, assessed by residual tablets count, revealed a drug intake of more than 80%
after 2 years in 92.5% and 92.8% of patients treated with ipriflavone or placebo, respectively. This study demonstrates that
ipriflavone can prevent bone loss in postmenopausal women with low bone mass.
Received: 1 April 1996 / Accepted: 5 March 1997 相似文献
994.
L. Rosenthall 《Calcified tissue international》1997,61(2):139-141
This study was designed to determine the changes in precision of the ultrasound parameters speed of sound (SOS), broadband
ultrasound attenuation (BUA), and stiffness index (SI) as a function of bone quality. The instrument used in this investigation
was the LUNAR Achilles. Of the 608 female patients who had paired measurements with repositioning, 200 had t scores ≥−1 and 408 had t scores ≤−2.5, thus rendering a normal and a grossly abnormal group for comparison of precision results. It was found that
the median precision error (CV%) for BUA was 1.99% for normal bone and 1.44% for abnormal bone (P= 0.02). No significant difference was obtained between median precision errors in normal and abnormal bone for the parameters
SOS and SI, which were 0.23% and 0.19%, and 2.15% and 2.02%, respectively. In the interquartile range, the mean precision
errors for SOS and BUA were significantly different in normal and abnormal bone: SOS was 0.25% and 0.21%, respectively, and
BUA was 2.31% and 1.85%, respectively. No significant change was registered for SI. Precision error appears to decrease slightly
at lower values for calcaneal variables.
Received: 21 August 1996 / Accepted: 5 March 1997 相似文献
995.
Zweiunddrei?ig Patienten mit Metastasenkrankheit der Wirbels?ule, überwiegend von Mammakarzinomen und Plasmozytomen wurden
über 41/2 Jahre operativ dekomprimiert und stabilisiert. Unter Einbeziehung von 5 früh Verstorbenen, betr?gt die mittlere
überlebenszeit 9,5 Monate. Bei Entlassung der überlebenden aus station?rer Behandlung waren mit einer Ausnahme alle Patienten
gehf?hig. In der Regel kamen Verbundosteosynthesen, bevorzugt der ventrale Zugang, zur Anwendung. Die pr?operative Embolisation
war ein unverzichtbarer Bestandteil des Managements. Die operative Behandlung der Wirbels?ulenmetastasen ist eine segensreiche
Methode, die in das gesamte Behandlungskonzept der bedauernswerten Patienten frühzeitig integriert werden sollte. Hochgradige
Paresen oder Paralysen, insbesondere nach fudroyantem Verlauf, nicht kontrollierte Prim?rtumoren und spezielle Tumoren, z.
B. das Bronchialkarzinom sowie gastrointestinale Karzinome, sind auch in der eigenen Serie indikatorisch eher kritisch zu
sehen.
相似文献
996.
Henryk Barthel Michael Wiener Claudia Dannenberg Simone Bettin Bernhard Sattler Wolfram H. Knapp 《European journal of nuclear medicine and molecular imaging》1997,24(10):1245-1252
This study addresses the question of whether the normal range for distribution of local cerebral blood flow (lCBF) in adults
can be transferred to the 4- to 15-year-old age group. Twenty-three children (age: 4–15 years; mean 11±3 years, group I) and
10 adults (age: 27–56 years; mean 45±10 years, group II) without evidence of cerebrovascular disease or other brain diseases
underwent technetium-99m ethyl cysteinate dimer single-photon emission tomography. Counts in cortical and subcortical regions
of interest (ROIs) were related to those in cerebellar ROIs (= 100%). Relative cortical activity in group I exceeded that
in group II, particularly in left parietal (107.6%±9.8% vs 84.1%±12.4%), left frontal (97.7%±6.7% vs 79.4%±8.9%) and left
temporal areas (99.7%±7.4% vs 84.9%±10.1%) and in the cingulate cortex (112.1%±9.1% vs 95.9%±10.1%, P<0.05). Cerebral activity uptake per injected dose was inversely correlated with age in 19 children of group I (r = –0.77, P<0.001). In group I, there was also an inverse correlation between age and the relative local count density in the parietal
(r = –0.42 to –0.57), frontal (r = –0.48), temporal (r = –0.42 to –0.58) and occipital cortex (r = –0.44). In these cortical regions relative counts differed when subgroups of children aged 4–10 and 11–15 years were analysed.
It is concluded that there are systematic differences between 4- to 15-year-old children and adults with regard to normal
lCBF. Diagnostic use of perfusion agents has to consider age-adjusted normal flow maps; normal ranges should be determined
separately for the age groups 4–10 and 11–15 years.
Received 23 March and in revised form 11 July 1997 相似文献
997.
998.
婴幼儿感染性腹泻是婴幼儿常见病之一,近年来在病原学方面有明显变迁,以致病性大肠杆菌感染多见,据我院儿科1989年的统计结果表明,大肠艾希氏菌和克雷伯氏菌感染明显上升,病程长,病情重,应引起重视,本文就1989年1年的婴幼儿感染性腹泻的发病机制与病原学进行了分析。 相似文献
999.
Dennis A. Revicki Harris Allen Kathleen Bungay Gordon H. Williams Milton C. Weinstein 《Journal of clinical epidemiology》1994,47(12):1333-1342
We examined the discriminant ability and responsiveness of the General Well-Being Adjustment Scale in patients enrolled in a randomized clinical trial of antihypertensive therapy. We also tried to translate the effects of physical symptoms on general well-being. This secondary analysis used demographic, clinical, physical symptom, and general well-being data for 545 white, male hypertensive patients. General well-being was measured by the General Well-Being Adjustment Scale (GWB) collected on 2 occasions over 8 weeks of treatment. Patients with any one of 14 physical symptoms or problems, compared to those without symptoms, had lower GWB scores (p < 0.003 to p < 0.0001). Decreases of 2.83–8.76 points in GWB scores were observed in patients developing physical symptoms over the 8 week study period (p < 0.05 to p < 0.0001). These effects were demonstrated in patients developing cold sensitivity, sexual problems, chest pain, shortness of breath, loss of taste, nausea, hot or cold spells, numbness and tingling, dry mouth, blurred vision, and dizziness. We conclude that the GWB is responsive to clinically meaningful changes in symptoms and may provide a more complete evaluation of the effects of medical treatment. The GWB is a valid and responsive measure of health status outcomes in the evaluation of antihypertensive treatment. 相似文献
1000.
本研究应用层粘连蛋白(LN)抗体,对27例乳腺癌、5例乳腺良性病变进行了免疫组织化学研究。结果发现乳腺良性病变时,LN以均匀完整的线型阳性反应显示在乳腺导管及小叶基膜处。乳腺癌时,LN的染色表现为癌细胞胞浆内弥漫状阳性反应。27例乳腺癌中,癌细胞LN染色强度不同,伴有转移的乳腺癌LN染色多数较强,强度在++~的为7/12(58.3%);不伴有转移的病例,LN染色多数较浅或为阴性,强度在++~+++的病例为3/15(20%)。说明癌细胞内源性LN染色强弱与肿瘤转移密切相关,内源性LN的合成可能改变肿瘤细胞的浸润活性。 相似文献