Effects of local application of methylprednisolone delivered by the C/GP-hydrogel on the recovery of facial nerves

Conclusions: Local administration of MP delivered by the C/GP-MP-hydrogel can improve the recovery of facial nerve following crush injury. The findings suggested that locally injected MP delivered by C/GP-hydrogel might be a promising treatment for facial nerve damage. Objectives: In this study, the aim is to assess the effectiveness of locally administrating methylprednisolone(MP) loaded by chitosan-β-glycerophosphate hydrogel (C/GP-hydrogel) on the regeneration of facial nerve crush injury. Methods: After the crush of left facial nerves, Wistar rats were randomly divided into four different groups. Then, four different therapies were used to treat the damaged facial nerves. At the 1^st, 2^nd, 3^rd, and 4^th week after injury, the functional recovery of facial nerves and the morphological changes of facial nerves were assessed. The expression of growth associated protein-43 (GAP-43) protein in the facial nucleus were also evaluated. Results: Locally injected MP delivered by C/GP-hydrogel effectively accelerated the facial functional recovery. In addition, the regenerated facial nerves in the C/GP-MP group were more mature than those in the other groups. The expression of GAP-43 protein was also improved by the MP, especially in the C/GP-MP group.     

A novel mutation in ALS2 associated with severe and progressive infantile onset of spastic paralysis

Infantile onset ascending spastic paralysis (IAHSP) is a type of recessively inherited spastic paraplegia. We investigated the clinical and genetic cause of a recessively inherited disorder in two siblings manifesting severe spasticity in the lower limbs which hindered their gait. A novel homozygous nonsense mutation c.1918 C?>?T (p.Arg640*) was identified after whole-exome sequencing within ALS2 in the DNA of both patients. The obligate carriers were heterozygous for the mutation and other unaffected members were homozygous for the wild type allele. The variant was absent from 100 control chromosomes and all public databases. This report extends the allelic heterogeneity of ALS2 mutations and emphasizes the importance of genetic testing for diagnosis of pediatric disorders.     

醒脑开窍针刺法治疗脑卒中后动眼神经麻痹临床观察

目的探讨醒脑开窍针刺法治疗脑卒中后动眼神经麻痹的临床疗效和安全性。方法选取2012-06—2014-06收治的86例脑卒中后并发动眼神经麻痹患者为研究对象,随机分为观察组和对照组2组,每组各43例,在常规西药治疗基础上,观察组应用醒脑开窍针刺法治疗,每日针刺1次;对照组应用常规针刺疗法治疗,每日针刺1次;2周为一疗程。观察比较2组有效率和不良反应发生率。结果治疗2周后,观察组总有效率93.02%,对照组为83.72%,观察组治疗总有效率高于对照组,差异有统计学意义(P0.05);观察组出现血肿、恶心和头晕各1例,对照组出现血肿、红色斑丘疹和恶心各1例,2组不良反应发生率比较,差异无统计学意义(P0.05)。结论应用醒脑开窍针刺法治疗脑卒中后动眼神经麻痹的临床效果肯定,安全性好,值得临床推广应用。     

蜈蚣胶囊联合针灸治疗急性面神经炎的疗效观察

目的：观察蜈蚣胶囊联合针灸治疗急性面神经炎（AFP）的疗效。方法：将60例AFP患者按随机数字表法分为两组,对照组30例患者仅接受常规西药治疗+针灸治疗,治疗组30例患者在对照组基础上加用蜈蚣胶囊治疗。结果：治疗2周后,治疗组疗效显著高于对照组（P<0．05）。结论：蜈蚣胶囊联合针灸治疗急性面神经炎可有效改善临床预后,疗效好,无明显不良反应。     

电针联合药物治疗周围性面瘫效果分析及其护理方法研究

目的：探讨电针联合药物在周围性面瘫患者中的临床治疗效果及其护理方法。方法对2013年4月—2014年4月来该院诊治的80例患者入院资料进行分析,将其随机分为两组。对照组采用药物治疗,实验组联合电针治疗,两组均行综合护理,比较两组治疗效果。结果实验组95%治疗效果理想,高于对照组（85%）,差异有统计学意义（P<0.05）;实验组95%对该院治疗总体满意,高于对照组,差异有统计学意义（P<0.05）;实验组3例出现不良反应,不良反应发生率为7.5%,低于对照组（7例出现不良反应,不良反应发生率为17.5%）,差异有统计学意义（χ2=4.58,P<0.05）。结论周围性面瘫发病率较高,临床上采用电针联合药物治疗效果理想,患者治疗过程中加强患者护理能够提高临床治疗效果,值得推广使用。     

开胸顺气胶囊治疗妇科腹部手术后早期肠麻痹的临床观察

目的观察开胸顺气胶囊对妇科手术后早期肠麻痹(胃肠气滞症)的临床疗效。方法 100例妇科手术后引起早期肠麻痹症状(胃肠气滞症)患者随机分为两组,治疗组50例口服开胸顺气胶囊,术后6 h服用3粒,术后18 h服用3粒;对照组50例口服曲美布汀,术后6 h服用3片,术后18 h服用3片,观察两组患者术后首次肛门排气、排便时间及下腹胀痛、恶心呕吐等症状。结果治疗组各项指标的改善情况均优于对照组(P0.05)。结论开胸顺气胶囊治疗妇科手术后引起早期肠麻痹症状(胃肠气滞症)疗效确切。     

艾灸治疗风寒型周围性面瘫23例

目的:观察艾灸治疗风寒型周围性面瘫的临床疗效。方法:选取风寒型周围性面瘫患者50例,随机分为对照组和试验组各25例。两组均给予常规药物和推拿治疗,试验组在此基础上加用艾灸治疗。结果:两组患者未能坚持治疗者,试验组2例,对照组1例。试验组Sunnybrook面神经评分、痊愈率均优于对照组(P<0.05)。结论:艾灸治疗风寒型周围性面瘫疗效显著。