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71.
72.
A. Hatch S. Madden M. Kohn S. Clarke S. Touyz L. M. Williams 《European eating disorders review》2010,18(3):165-179
We reviewed the evidence for emotion‐related disturbances in anorexia nervosa (AN) from behavioural, cognitive, biological and genetic domains of study. These domains were brought together within the framework of an integrative neuroscience model that emphasizes the role of emotion and feeling and their regulation, in brain organization. PsychInfo and Medline searches were performed to identify published peer‐reviewed papers on AN within each domain. This review revealed evidence for ‘Emotion’, ‘Thinking and Feeling’ and ‘Self‐regulation’ disturbances in AN that span non‐conscious to conscious processes. An integrative neuroscience framework was then applied to develop a model of AN, from which hypotheses for empirical investigation are generated. We propose that AN reflects a core disturbance in emotion at the earliest time stage of information processing with subsequent effects on the later stages of thinking, feeling and self‐regulation. Copyright © 2010 John Wiley & Sons, Ltd and Eating Disorders Association. 相似文献
73.
Efficient production of mesencephalic dopamine neurons by Lmx1a expression in embryonic stem cells 总被引:1,自引:0,他引:1
Stina Friling Elisabet Andersson Lachlan H. Thompson Marie E. Jnsson Josephine B. Hebsgaard Evanthia Nanou Zhanna Alekseenko Ulrika Marklund Susanna Kjellander Nikolaos Volakakis Outi Hovatta Abdeljabbar El Manira Anders Bjrklund Thomas Perlmann Johan Ericson 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(18):7613-7618
74.
Corrie R. Camalier William R. D’Angelo Susanne J. Sterbing-D’Angelo Lisa A. de la Mothe Troy A. Hackett 《Proceedings of the National Academy of Sciences of the United States of America》2012,109(44):18168-18173
Sensory systems across the brain are specialized for their input, yet some principles of neural organization are conserved across modalities. The pattern of anatomical connections from the primate auditory cortex to the temporal, parietal, and prefrontal lobes suggests a possible division into dorsal and ventral auditory processing streams, with the dorsal stream originating from more caudal areas of the auditory cortex, and the ventral stream originating from more rostral areas. These streams are hypothesized to be analogous to the well-established dorsal and ventral streams of visual processing. In the visual system, the dorsal processing stream shows substantially faster neural response latencies than does the ventral stream. However, the relative timing of putative dorsal and ventral stream processing has yet to be explored in other sensory modalities. Here, we compare distributions of neural response latencies from 10 different areas of macaque auditory cortex, confirmed by individual anatomical reconstructions, to determine whether a similar timing advantage is found for the hypothesized dorsal auditory stream. Across three varieties of auditory stimuli (clicks, noise, and pure tones), we find that latencies increase with hierarchical level, as predicted by anatomical connectivity. Critically, we also find a pronounced timing differential along the caudal-to-rostral axis within the same hierarchical level, with caudal (dorsal stream) latencies being faster than rostral (ventral stream) latencies. This observed timing differential mirrors that found for the dorsal stream of the visual system, suggestive of a common timing advantage for the dorsal stream across sensory modalities. 相似文献
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Dillan J. Newbold Evan M. Gordon Timothy O. Laumann Nicole A. Seider David F. Montez Sarah J. Gross Annie Zheng Ashley N. Nielsen Catherine R. Hoyt Jacqueline M. Hampton Mario Ortega Babatunde Adeyemo Derek B. Miller Andrew N. Van Scott Marek Bradley L. Schlaggar Alexandre R. Carter Benjamin P. Kay Deanna J. Greene Marcus E. Raichle Steven E. Petersen Abraham Z. Snyder Nico U. F. Dosenbach 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(13)
Whole-brain resting-state functional MRI (rs-fMRI) during 2 wk of upper-limb casting revealed that disused motor regions became more strongly connected to the cingulo-opercular network (CON), an executive control network that includes regions of the dorsal anterior cingulate cortex (dACC) and insula. Disuse-driven increases in functional connectivity (FC) were specific to the CON and somatomotor networks and did not involve any other networks, such as the salience, frontoparietal, or default mode networks. Censoring and modeling analyses showed that FC increases during casting were mediated by large, spontaneous activity pulses that appeared in the disused motor regions and CON control regions. During limb constraint, disused motor circuits appear to enter a standby mode characterized by spontaneous activity pulses and strengthened connectivity to CON executive control regions.Disuse is a powerful paradigm for inducing plasticity that has uncovered key organizing principles of the human brain (1–4). Monocular deprivation—prolonged covering of one eye—revealed that multiple afferent inputs can compete for representational territory in the primary visual cortex (1). Similar competition between afferents also shapes the somatomotor system. Manipulations such as peripheral nerve deafferentation, whisker trimming, and limb constraint all drive plasticity in the primary somatosensory and motor cortex (2–4). Most plasticity studies to date have used focal techniques, such as microelectrode recordings, to study local changes in brain function. As a result, little is known about how behavior and experience shape the brain-wide functional networks that support complex cognitive operations (5).The brain is composed of networks of regions that cooperate to perform specific cognitive functions (5–8). These functional networks show synchronized spontaneous activity while the brain is at rest, a phenomenon known as resting-state functional connectivity (FC) (9–11). FC can be measured noninvasively in humans using resting-state functional MRI (rs-fMRI) and has been used to parse the brain into canonical functional networks (12, 13), including visual, auditory, and somatomotor networks (14, 15); ventral and dorsal attention networks (8, 16); a default mode network with roles in internally directed cognition and episodic memory (7, 11); a salience network thought to assess the homeostatic relevance of external stimuli (17); a frontoparietal control network supporting error processing and moment-to-moment adjustments in behavior (18–20); and a cingulo-opercular control network (CON), which maintains executive control during goal-directed behavior (18, 19, 21). Each functional network likely carries out a variety of additional functions.A more recent advance in human neuroscience has been the recognition of individual variability in network organization (22–25). Most early rs-fMRI studies examined central tendencies in network organization using group-averaged FC measurements (10, 12, 13). Recent work has demonstrated that functional networks can be identified in an individual-specific manner if sufficient rs-fMRI data are acquired, an approach termed precision functional mapping (PFM) (22, 23, 26–30). PFM respects the unique functional anatomy of each person and avoids averaging together functionally distinct brain regions across individuals.We recently demonstrated that PFM can be used to follow the time course of disuse-driven plasticity in the human brain (31). Three adult participants (Nico, Ashley, and Omar) were scanned at the same time of day for 42 to 64 consecutive days (30 min of rs-fMRI per day) before, during, and after 2 wk of dominant upper-extremity casting (Fig. 1 A and B). Casting caused persistent disuse of the dominant upper extremity during daily behaviors and led to a marked loss of strength and fine motor skill in all participants. During casting, the upper-extremity regions of the left primary somatomotor cortex (L-SM1ue) and right cerebellum (R-Cblmue) functionally disconnected from the remainder of the somatomotor network. Disused motor circuits also exhibited large, spontaneous pulses of activity (Fig. 1C). Disuse pulses did not occur prior to casting, started to occur frequently within 1 to 2 d of casting, and quickly waned after cast removal.Open in a separate windowFig. 1.Experimental design and spontaneous activity pulses. (A) Three participants (Nico, Ashley, and Omar) wore casts covering the entire dominant upper extremity for 2 wk. (B) Participants were scanned every day for 42 to 64 consecutive days before, during, and after casting. All scans included 30 min of resting-state functional MRI. (C) During the Cast period, disused somatomotor circuits exhibited large pulses of spontaneous activity. (C, Left) Whole-brain ANOVA showing which brain regions contained disuse-driven pulses. (C, Right) Time courses of all pulses recorded from the disused primary somatomotor cortex.Somatomotor circuits do not function in isolation. Action selection and motor control are thought to be governed by complex interactions between the somatomotor network and control networks, including the CON (18). Prior studies of disuse-driven plasticity, including our own, have focused solely on somatomotor circuits. Here, we leveraged the whole-brain coverage of rs-fMRI and the statistical power of PFM to examine disuse-driven plasticity throughout the human brain. 相似文献
77.
Fichtenholtz HM Hopfinger JB Graham R Detwiler JM LaBar KS 《Social cognitive and affective neuroscience》2007,2(4):323-333
The goal of the present study was to characterize the effectsof valence in facial cues and object targets on event-relatedpotential (ERPs) indices of gaze-directed orienting. Participantswere shown faces at fixation that concurrently displayed dynamicgaze shifts and expression changes from neutral to fearful orhappy emotions. Emotionally-salient target objects subsequentlyappeared in the periphery and were spatially congruent or incongruentwith the gaze direction. ERPs were time-locked to target presentation.Three sequential ERP components were modulated by happy emotion,indicating a progression from an expression effect to a gaze-by-expressioninteraction to a target emotion effect. These effects includedlarger P1 amplitude over contralateral occipital sites for targetsfollowing happy faces, larger centrally distributed N1 amplitudefor targets following happy faces with leftward gaze, and fasterP3 latency for positive targets. In addition, parietally distributedP3 amplitude was reduced for validly cued targets followingfearful expressions. Results are consistent with accounts ofattentional broadening and motivational approach by happy emotion,and facilitation of spatially directed attention in the presenceof fearful cues. The findings have implications for understandinghow socioemotional signals in faces interact with each otherand with emotional features of objects in the environment toalter attentional processes. 相似文献
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79.
William Bechtel 《Brain and Mind》2002,3(2):229-242
This paper defends cognitive neuroscience's project of developingmechanistic explanations of cognitive processes through decompositionand localization against objections raised by William Uttal inThe New Phrenology. The key issue between Uttal and researcherspursuing cognitive neuroscience is that Uttal bets against thepossibility of decomposing mental operations into component elementaryoperations which are localized in distinct brain regions. The paperargues that it is through advancing and revising what are likely tobe overly simplistic and incorrect decompositions that the goals ofcognitive neuroscience are likely to be achieved. 相似文献
80.
Thilo Deckersbach PhD Darin D. Dougherty MD Scott L. Rauch MD 《Journal of neuroimaging》2006,16(1):1-10
Neuroimaging research has emerged as a valuable tool in shaping our understanding of the pathophysiology of psychiatric disorders. We review functional neuroimaging findings pertaining to mood disorders (major depression, bipolar disorders) as well as selected anxiety disorders (posttraumatic stress disorder [PTSD] and obsessive-compulsive disorder [OCD]). 相似文献