Increased incidence of retching and vomiting during periovulatory phase after middle ear surgery

Purpose  

To assess the effect of the menstrual cycle on post-operative retching and vomiting (R& V) after middle ear surgery, and the efficacy of prophylaxis against R& V in female patients with transdermal scopolamine during either general or local anaesthesia and with intravenous ondansetron during general anaesthesia.     

Lack of presynaptic modulation by isoprenaline of 3H-noradrenaline release from rabbit isolated ear artery

Summary The aim of the present investigation was to examine whether or not presynaptic facilitatory -adrenoceptors are detectable on the postganglionic nerves in the rabbit isolated ear artery. Strips of rabbit central ear artery were incubated with ³H-noradrenaline (10^–7 mol/l; 30 min or 10^–6 mol/l; 60 min). Subsequently, they were washed repeatedly with physiological salt solution. The strips were subjected to electrical-field stimulation (S₁–S₈) and the resultant ³H-overflow was determined.When the ear artery was stimulated with 150 pulses (0.5 ms; 3 Hz; 225 mA), isoprenaline (10^–9–10^–6 mol/l) either alone or in the presence of either rauwolscine (10^–6 mol/l) or phentolamine (10^–6 mol/l) did not alter the stimulation-evoked ³H-overflow. This was also the case in the presence of rauwolscine (10^–6 mol/l) plus either the selective phosphodiesterase inhibitor ICI 63 197 (3 × 10^–5 mol/l) or forskolin (10^–6 mol/l). When the ear artery was stimulated with 300 pulses (1 ms; 5 Hz; 225 mA), isoprenaline had no effect on the stimulation-evoked ³H-overflow. This was also the case when phentolamine (10^–6 mol/l) was present. Propranolol (10^–7–10^–5 mol/l) did not alter the stimulation-evoked ³H-overflow. In some experiments, the stimulation current was reduced to 175 mA in order to obtain similar reference release (S₃) values despite the presence of rauwolscine (150 pulses; 0.5 ms; 3 Hz). Even then, isoprenaline (10^–9–10^–6 mol/l) did not change stimulation-evoked ³H-overflow. The results suggest that postganglionic sympathetic nerves in rabbit central ear artery do not possess presynaptic facilitatory -adrenoceptors. Send offprint requests to J. Abrahamsen at the above address     

高同型半胱氨酸血症及MTHFR基因与中青年脑梗死的研究

目的 :探讨高同型半胱氨酸血症 (HHC)及N5,N10-亚甲四氢叶酸还原酶(MTHFR)基因型与中青年脑梗死的关系。方法 :采用高压液相色谱法及PCR -RFLP技术测定80例脑梗死患者和40例正常对照者的血浆总同型半胱氨酸水平 (tHcy)和MTHFR基因多态性。结果 :患者组中MTHFR基因T/T纯合型频率为33.75 % ,T等位基因频率为58.75 % ,显著高于对照组的20 %和36.25 % (P<0.05) ;患者组血浆tHcy均值为22.70μmol/L ,对照组仅为13.19μmol/L ,患者组HHC31例 ,对照组仅为2例 ,2组差别有统计学意义,且2组T/T型者血浆tHcy水平高于T/C型和C/C型者。结论 :MTHFR基因突变可能是脑梗死发生的一个遗传易感因素 ,tHcy可能与血脂血糖一样是脑卒中发病的一个独立危险因素     

Otological trauma resulting from the Soho Nail Bomb in London,April 1999

Otological trauma resulting from the Soho Nail Bomb in London, April 1999 We report the otological effects of the April 1999 Soho Nail Bomb on 17 patients. Twenty‐one (62%) tympanic membranes were perforated (pars tensa only); 78% closed spontaneously within 6 months. The mean size of the perforation in the tympanic membrane nearer to the blast was significantly larger than the opposite side [33% ± 8.3 (mean ± SD) and 13% ± 4.1 respectively; P = 0.02]. All patients reported hearing losses that were mixed conductive and sensorineural but mainly high‐frequency sensorineural (4, 6 and 8 kHz, pure tone average 42.3 dB ± 20.5). The sensorineural hearing loss correlated inversely with the distance from the explosion but not with the size of perforation. There was no significant difference in the hearing loss between the ear facing the blast and the opposite ear. Fifteen patients (88%) had temporary tinnitus. No patient complained of any vestibular symptoms. The otological effects of a nail bomb in an enclosed space have not been previously reported. Furthermore, an inverse correlation between hearing loss and distance from the explosion and a significant difference in perforation size facing the blast, compared with the opposite side, are also presented for the first time. The high spontaneous closure rate of perforations and minimal ongoing disability from sensorineural losses favour conservative management in most cases.     

甘西鼠尾草注射液和丹参注射液抗大鼠急性脑缺血和抗脂质过氧化作用的比较

目的：比较甘西鼠尾草和丹参两种注射液对大鼠急性脑缺血的影响，并对其作用机理进行探讨。方法：采用大脑中动脉阻断术（MCAO）制作大鼠急性脑缺血模型。采用计算机图像分析仪测定脑梗死的体积，TBA比色法测定血清MDA含量，放免法测定血清SOD含量；电子自旋共振（ESR）法测定药物对羟自由基的清除作用。结果：甘西鼠尾草注射液和丹参注射液均可明显减小急性脑缺血大鼠脑梗死体积，降低血清MDA含量，升高血清SOD含量，体外清除羟自由基的作用甘西鼠尾草强于丹参。结论：甘西鼠尾草和丹参两种注射液作用基本相同。提示甘西鼠尾草有可能成为丹参的代用品。     

Yellow nail syndrome in infancy

Abstract: This report describes an infant with clinical features consistent with the yellow nail syndrome (YNS), a rare autosomal dominant disorder. He presented at birth with congenital lymphoedema and was referred at 6 months of age for investigation of recurrent cough and wheeze. He had clinical and radiological evidence of bilateral pleural effusions and a pericardial effusion. Following a lung biopsy and pericardial window these were shown to be manifestations of his lymphatic abnormality. He also had persisting middle ear effusions causing conductive deafness requiring hearing aids and secondary immunodeficiency requiring regular immunoglobulin infusions.     

盐酸洛美沙星滴耳剂稳定性研究

 目的:预测盐酸洛美沙星滴耳剂有效期，用以扩大洛美沙星的临床应用，增加耳科用药。方法:采用紫外分光光度法剧定制剂含重.用经典恒温法和Weibull概率法探讨其德定性。结果:紫外分光光度法测定制剂含量平均回收率为99.80% ,RSD为0.66%。经典恒温法预测本制剂在pH为5～6, 25 ℃ 贮存时有效期为5.16年，Weibull概率法预测其有效期为4.98年。结论:紫外分光光度法测定盐酸洛美沙星滴耳剂快速简便，精密度好，可靠性高。在无阳光直射条件下室温贮存本制剂稳定性好。     

抗癌宝口服液治疗中晚期恶性肿瘤103例临床观察

目的：观察中药抗癌宝口服液治疗中晚期恶性肿瘤临床效果。方法：１０３例患者随机分为抗癌宝观察组与化疗对照组，对两组疗效作比较。结果：观察组患者免疫功能，近期有效率（ＣＲ＋ＰＲ），生存质量，１、２、３年生存期及中位生存时间，癌胚抗原下降水平，明显高于对照组，且有显著性差异。结论：抗癌宝具有抑制肿瘤生长，延长生存时间，提高生存质量之效。     

世界中西医结合大会在京召开──交流中西医结合在理论、临床、教育及政策管理方面经验

世界中西医结合大会在京召开──交流中西医结合在理论、临床、教育及政策管理方面经验人民日报北京１０月２７日讯世界中西医结合大会今天在北京国际会议中心开幕。大会以“继承、发扬、结合、创新”为主题，交流重点是中西医结合在理论、临床、教育及政策管理等各方面的...