全文获取类型
收费全文 | 44916篇 |
免费 | 3535篇 |
国内免费 | 780篇 |
专业分类
耳鼻咽喉 | 157篇 |
儿科学 | 452篇 |
妇产科学 | 372篇 |
基础医学 | 2315篇 |
口腔科学 | 350篇 |
临床医学 | 5231篇 |
内科学 | 2765篇 |
皮肤病学 | 307篇 |
神经病学 | 887篇 |
特种医学 | 947篇 |
外科学 | 1912篇 |
综合类 | 11491篇 |
现状与发展 | 2篇 |
一般理论 | 38篇 |
预防医学 | 15749篇 |
眼科学 | 829篇 |
药学 | 2400篇 |
284篇 | |
中国医学 | 1992篇 |
肿瘤学 | 751篇 |
出版年
2024年 | 117篇 |
2023年 | 685篇 |
2022年 | 1362篇 |
2021年 | 1839篇 |
2020年 | 2134篇 |
2019年 | 1407篇 |
2018年 | 1356篇 |
2017年 | 1306篇 |
2016年 | 1317篇 |
2015年 | 1269篇 |
2014年 | 3300篇 |
2013年 | 3515篇 |
2012年 | 3184篇 |
2011年 | 3511篇 |
2010年 | 2894篇 |
2009年 | 2455篇 |
2008年 | 2741篇 |
2007年 | 2543篇 |
2006年 | 2184篇 |
2005年 | 1753篇 |
2004年 | 1404篇 |
2003年 | 1105篇 |
2002年 | 837篇 |
2001年 | 686篇 |
2000年 | 596篇 |
1999年 | 447篇 |
1998年 | 382篇 |
1997年 | 350篇 |
1996年 | 305篇 |
1995年 | 273篇 |
1994年 | 191篇 |
1993年 | 108篇 |
1992年 | 118篇 |
1991年 | 158篇 |
1990年 | 141篇 |
1989年 | 121篇 |
1988年 | 120篇 |
1987年 | 92篇 |
1986年 | 111篇 |
1985年 | 102篇 |
1984年 | 100篇 |
1983年 | 87篇 |
1982年 | 93篇 |
1981年 | 68篇 |
1980年 | 71篇 |
1979年 | 35篇 |
1978年 | 61篇 |
1977年 | 62篇 |
1976年 | 59篇 |
1975年 | 41篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
992.
《Vaccine》2015,33(21):2470-2476
Background/objectivesAnthrax vaccine adsorbed (AVA, BioThrax®) is recommended for post-exposure prophylaxis administration for the US population in response to large-scale Bacillus anthracis spore exposure. However, no information exists on AVA use in children and ethical barriers exist to performing pre-event pediatric AVA studies. A Presidential Ethics Commission proposed a potential pathway for such studies utilizing an age de-escalation process comparing safety and immunogenicity data from 18 to 20 year-olds to older adults and if acceptable proceeding to evaluations in younger adolescents. We conducted exploratory summary re-analyses of existing databases from 18 to 20 year-olds (n = 74) compared to adults aged 21 to 29 years (n = 243) who participated in four previous US government funded AVA studies.MethodsData extracted from studies included elicited local injection-site and systemic adverse events (AEs) following AVA doses given subcutaneously at 0, 2, and 4 weeks. Additionally, proportions of subjects with ≥4-fold antibody rises from baseline to post-second and post-third AVA doses (seroresponse) were obtained.ResultsRates of any elicited local AEs were not significantly different between younger and older age groups for local events (79.2% vs. 83.8%, P = 0.120) or systemic events (45.4% vs. 50.5%, P = 0.188). Robust and similar proportions of seroresponses to vaccination were observed in both age groups.ConclusionsAVA was safe and immunogenic in 18 to 20 year-olds compared to 21 to 29 year-olds. These results provide initial information to anthrax and pediatric specialists if AVA studies in adolescents are required. 相似文献
993.
Sensitivity of regression calibration to non‐perfect validation data with application to the Norwegian Women and Cancer Study
下载免费PDF全文
![点击此处可从《Statistics in medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
John P. Buonaccorsi Ingvild Dalen Petter Laake Anette Hjartåker Dagrun Engeset Magne Thoresen 《Statistics in medicine》2015,34(8):1389-1403
Measurement error occurs when we observe error‐prone surrogates, rather than true values. It is common in observational studies and especially so in epidemiology, in nutritional epidemiology in particular. Correcting for measurement error has become common, and regression calibration is the most popular way to account for measurement error in continuous covariates. We consider its use in the context where there are validation data, which are used to calibrate the true values given the observed covariates. We allow for the case that the true value itself may not be observed in the validation data, but instead, a so‐called reference measure is observed. The regression calibration method relies on certain assumptions.This paper examines possible biases in regression calibration estimators when some of these assumptions are violated. More specifically, we allow for the fact that (i) the reference measure may not necessarily be an ‘alloyed gold standard’ (i.e., unbiased) for the true value; (ii) there may be correlated random subject effects contributing to the surrogate and reference measures in the validation data; and (iii) the calibration model itself may not be the same in the validation study as in the main study; that is, it is not transportable. We expand on previous work to provide a general result, which characterizes potential bias in the regression calibration estimators as a result of any combination of the violations aforementioned. We then illustrate some of the general results with data from the Norwegian Women and Cancer Study. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
994.
Testing a sequence of pre‐ordered hypotheses to decide which of these can be rejected or accepted while controlling the familywise error rate (FWER) is of importance in many scientific studies such as clinical trials. In this paper, we first introduce a generalized fixed sequence procedure whose critical values are defined by using a function of the numbers of rejections and acceptances, and which allows follow‐up hypotheses to be tested even if some earlier hypotheses are not rejected. We then construct the least favorable configuration for this generalized fixed sequence procedure and present a sufficient condition for the FWER control under arbitrary dependence. Based on the condition, we develop three new generalized fixed sequence procedures controlling the FWER under arbitrary dependence. We also prove that each generalized fixed sequence procedure can be described as a specific closed testing procedure. Through simulation studies and a clinical trial example, we compare the power performance of these proposed procedures with those of the existing FWER controlling procedures. Finally, when the pairwise joint distributions of the true null p‐values are known, we further improve these procedures by incorporating pairwise correlation information while maintaining the control of the FWER. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
995.
Evaluation of intervention effects on multiple outcomes is a common scenario in clinical studies. In longitudinal studies, such evaluation is a challenge if one wishes to adequately capture simultaneous data behavior. In this situation, a common approach is to analyze each outcome separately. As a result, multiple statistical statements describing the intervention effect need to be reported and an adjustment for multiple testing is necessary. This is typically done by means of the Bonferroni procedure, which does not take into account the correlation between outcomes, thus resulting in overly conservative conclusions. We propose an alternative approach for multiplicity adjustment that incorporates dependence between outcomes, resulting in an appreciably less conservative evaluation. The ability of the proposed method to control the familywise error rate is evaluated in a simulation study, and the applicability of the method is demonstrated in two examples from the literature. Copyright © 2015 John Wiley & Sons, Ltd. 相似文献
996.
Alexander G Fiks Peixin Zhang A Russell Localio Saira Khan Robert W Grundmeier Dean J Karavite Charles Bailey Evaline A Alessandrini Christopher B Forrest 《Health services research》2015,50(2):489-513
ObjectiveSubstantial investment in electronic health records (EHRs) has provided an unprecedented opportunity to use clinical decision support (CDS) to increase guideline adherence. To inform efforts to maximize adoption, we characterized the adoption of an otitis media (OM) CDS system, the impact of performance feedback on adoption, and the effects of adoption on guideline adherence.ConclusionsPerformance feedback increased CDS adoption, but additional strategies are needed to integrate CDS into primary care workflows. 相似文献
997.
Flexible selection of a single treatment incorporating short‐term endpoint information in a phase II/III clinical trial
下载免费PDF全文
![点击此处可从《Statistics in medicine》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Nigel Stallard Cornelia Ursula Kunz Susan Todd Nicholas Parsons Tim Friede 《Statistics in medicine》2015,34(23):3104-3115
Seamless phase II/III clinical trials in which an experimental treatment is selected at an interim analysis have been the focus of much recent research interest. Many of the methods proposed are based on the group sequential approach. This paper considers designs of this type in which the treatment selection can be based on short‐term endpoint information for more patients than have primary endpoint data available. We show that in such a case, the familywise type I error rate may be inflated if previously proposed group sequential methods are used and the treatment selection rule is not specified in advance. A method is proposed to avoid this inflation by considering the treatment selection that maximises the conditional error given the data available at the interim analysis. A simulation study is reported that illustrates the type I error rate inflation and compares the power of the new approach with two other methods: a combination testing approach and a group sequential method that does not use the short‐term endpoint data, both of which also strongly control the type I error rate. The new method is also illustrated through application to a study in Alzheimer's disease. © 2015 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd. 相似文献
998.
999.
1000.