奥氮平与氯氮平联合心境稳定剂治疗躁狂症对照研究

目的　比较奥氮平与氯氮平治疗躁狂症的疗效与不良反应。方法　将符合CCMD 3双相情感性精神障碍躁狂相或躁狂发作诊断标准的 78例患者 ,随机分为研究组 (奥氮平联合心境稳定剂组 ) 38例和对照组 (氯氮平联合心境稳定剂组 ) 4 0例 ,分别进行 6w的治疗和观察 ,并于入组时和治疗第 1、2、4、6w末应用BRMS各评定 1次 ,以TESS评定不良反应 ,以Beck -Rafaelsen减分率评定临床疗效。结果　研究组与对照组治疗 6w末躁狂症状均有显著性改善 ,有效率分别为 94 .7%和 92 .5 % ,两组间比较无显著性差异 (P >0 .0 5 ) ,药物不良反应研究组显著少于对照组。结论　奥氮平是一种有效的抗躁狂药物 ,不良反应少且轻     

Oligodendroglioma presenting as chronic mania

Summary

Oligodendrogliomas may present with a variety of psychological symptoms but it only rarely presents with mania. The patient described in this case report is a 55-year-old man with a three year history of progressive mania who was initially diagnosed as chronic mania but a subsequent MRI identified a brain tumor. This report highlights the importance of considering differential organic diagnosis when patients present with atypical presentations of psychiatric disorders. A brain tumor should be considered and brain imaging studies conducted for patients with a late age of onset who do not respond to appropriate medication.

 

      

躁狂症病人围手术期心理干预

目的探讨心理干预和医护结合治疗措施在躁狂症病人围手术期治疗过程中的应用及效果。方法将100例合并外科疾病的围手术期躁狂症病人随机分为干预组(50例)及对照组(50例),两组接受相似的抗躁狂药治疗及外科手术治疗方案,干预组在围手术期治疗过程中给予心理干预和医护结合治疗措施。结果通过两组对比研究,发现干预组与对照组在焦虑程度、治疗配合程度等方面比较,差异有显著性(p<0.01)。干预组治疗配合程度好于对照组,好转率高于对照组。结论对躁狂症病人围手术期开展心理干预和医护结合治疗措施,在缓解症状和提高病人治疗配合程度方面有明显促进的作用。     

Videotaped reliability in a multicenter collaborative investigation of divalproex sodium for the treatment of mania

This study describes the procedures used to establish videotaped inter-rater reliability in a multicenter study investigating the clinical efficacy of divalproex sodium for the treatment of acute mania. A total of 46 raters from 10 centers viewed and rated five videotaped diagnostic patients interviews using a modified SADS and SADS-C. Raters also viewed a follow-up videotaped interview at the midpoint of the study. Raters rated the quality of each interview for its teaching potential. Agreement among raters within study sites was estimated by the intraclass correlation coefficient. Results demonstrated significant agreement among raters within study centers at baseline and follow-up for both the SADS and SADS-C.     

Thrombocyte monoamine oxidase activity and personality traits in women with severe premenstrual syndrome

Women with premenstrual syndrome (PMS) of such severity that they actively had sought medical attention for their symptoms were compared with healthy female students with regard to platelet MAO activity and temperamental correlates by means of the Karolinska Scales of Personality (KSP), scales from the Eysenck Personality Questionnaire (EPQ) and Eysenck's IVE inventory. The women with PMS were divided into two groups; irritability and depression as predominating symptom. No variation in platelet MAO was found during the menstrual cycle, either in patients or in controls. Both PMS groups had significantly lower platelet MAO activity than the controls. There was no difference between the two groups with PMS. Also with regard to personality traits there were considerable differences between the females with PMS and the controls. There were few differences between the two groups of PMS patients. Thus, the patients scored significantly higher as regards somatic anxiety, muscular tension, indirect aggression, verbal aggression and neuroticism and lower as regards socialization than the controls.