Age, fiber type composition and in vitro contracture responses in human malignant hyperthermia

Muscle fiber typing and in vitro contracture tests were performed in 59 patients investigated for susceptibility to malignant hyperthermia (MH). Eighteen patients were found to be susceptible to MH. There was no difference in age or fiber type distribution between MH susceptible and non-susceptible patients. No correlation was found between age and fiber type distribution. Separate analyses for each diagnostic group revealed no relationship between age or fiber type distribution and response to halothane or caffeine. When all caffeine results were pooled, however, there was a significant effect of age on the caffeine specific concentration (the concentration eliciting a contracture of 1 g), but not on the caffeine threshold concentration (the minimal concentration eliciting an increase in tension). It is concluded that age and fiber type distribution have no influence on MH diagnosis, if the protocol of the European MH Group for evaluation of susceptibility to MH is followed.     

涎腺恶性肿瘤的回顾性研究

本文对52例涎腺恶性肿瘤进行了回顾性研究。52例中发生于腮腺者27例(51.9％);病理类型以腺样囊性癌和粘液表皮样癌最多见;随访2～8年,死亡19例,病死率最高者为腺癌(5/8)和鳞癌(3/5)。作者对腺样囊性癌的病理分型提出了不同看法。     

Evaluation of CHIP (iproplatin) in recurrent pediatric malignant solid tumors

CHIP (325 mg/M²), a second generation cisplatin derivative, was administered intravenously every 3 weeks to 85 pediatric patients with recurrent sarcomas (19), osteosarcomas (20), neuroblastoma (23), germ cell tumors (10), and other malignant tumors (7). Thirty-eight of them had been previously exposed to cisplatin. Partial remissions were only observed in 3 of 23 (13% SE=7%) patients having neuroblastoma. Severe thrombocytopenia (65%) and neutropenia (35%) were the dose limiting factors.     

颈部神经鞘瘤34例临床分析

对３４例颈部神经鞘瘤进行了临床分析，均以颈部无痛性包块为主诉。１６例压迫肿瘤可引起肢端麻木、放射性疼痛或压气、呛咳等症状，１０例肿块穿刺抽出囊液，８２．２％来诊时诊断不清楚，需与颈部其他肿瘤相鉴别，Ｂ超对诊断有帮助。本组手术行肿瘤核除术１３例，肿瘤切除术１９例，取病理２例。应争取做保留神经功能的肿瘤核除术。     

Thick malignant melanomas (> 3 mm Breslow) with good clinical outcome: a histological study and survival analysis

Thick malignant melanomas in general tend to have a poor prognosis, but exceptions occur where there may be no further recurrence. The reasons for this difference in clinical behaviour are not fully understood. We have looked at thick malignant melanomas (greater than 3.0 mm) in the East of Scotland that have no evidence of metastasis after a minimum of 6 years follow-up and compared the clinical and histological features with a similar group, associated with histological evidence of metastasis and/or death. Both groups received similar treatment regimes. We have identified 41 patients with thick melanomas in the former group. When compared with the control group, factors found to be significantly different between the two groups were: the nature of the lower margin of the tumour; vascular invasion; and anatomical location.     

Bilocular atrial malignant mesenchymoma causing mitral and localized pulmonary vein flow obstruction: diagnosis by transoesophageal echocardiography.

Cardiac malignant mesenchymoma is an extremely rare malignancy with poor prognosis. We report a patient presenting with a history and clinical findings typical of mitral stenosis. Transthoracic echocardiography showed a mass on the thickened posterior mitral leaflet. Transoesophageal echocardiography revealed two tumoural masses: one on the atrial side of the posterior mitral leaflet causing mitral obstruction, the other arising in the region of the right lower pulmonary vein orifice and obstructing inflow through this vein.     

植入镍钛记忆合金支架治疗恶性胆道梗阻的临床分析

目的 评价植入镍钛记忆合金支架治疗恶性胆道梗阻的疗效。方法 对16例恶性胆道梗阻患者。采用经手术及介入方法植入镍钛记忆合金胆道支架。结果 术后1个月内死亡1例，15例黄疸完全解除。随访15例，12例术后平均生存13．1个月。结论 植入镍钛合金胆道支架可提高姑息切除的疗效；对不能切除病灶患者，支架植入可解除黄疸，改善生活质量。     

Malignant Warthin''s tumour: a case study

Malignant transformation of a benign Warthin's tumour (adenolymphoma) is extremely rare. The light microscopic and ultrastructural features of an adenocarcinoma arising in a Warthin's tumour in the parotid gland are described. Light microscopy demonstrated a transition zone from the benign to the malignant component, and the malignant cells revealed oncocytic features by both light- and electronmicroscopy.     

TIL／rIL－2免疫过继疗法治疗晚期瘤性胸水初探

７例晚期瘤性胸水的肿瘤浸润淋巴细胞（ＴＩＬ）经体外诱导培养３～１２ｄ，扩增１～９倍．其ＣＤ８及ＩＬ－２Ｒ阳性细胞百分率增加２．４３和２．７６倍；ＮＫ活力增加３．２９倍，与培养前后比较有显著差异。ＴＩＬ／ｒＩＬ－２（重组人白细胞介素２）胸腔内回输后，４例胸水及胸水中肿瘤细胞消失，癌胚抗原（ＣＥＡ）回至正常水平，２例胸水减少，１例因多房性胸水停止治疗，ＣＥＡ水平上升。经１～８个月随访患者心、肝、肾功能正常。     

原发睾丸恶性淋巴瘤：（附13例报告）

自1977～1988年我院共收治13例原发睾丸恶性淋巴瘤,占同期睾丸恶性肿瘤的11.5％。本病少见,大部分发生在50岁以上。本文50岁以上者10例,约占80％。此病预后差,本文11侧2年内死亡,占85％。5年生存率仅为15％。本文5例术后辅以放、化疗,8例术后单纯化疗,两者生存期无明显差异,故我们认为手术 化疗为本病的首选治疗方案。