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201.
A. Al Tahan S. Arora A. Alzeer F. Al Tahan T. Malabarey A. Daif 《European journal of neurology》1997,4(1):52-58
The diagnosis of acute disseminated encephalomyelitis (ADEM) is frequently missed or delayed with consequent delay in instituting therapy in the crucial phase of the illness. The role of MRI in the diagnosis of ADEM is well established, however, the value of its early utilization of treatment on the outcome of patients has not been adequately stressed. Three patients with ADEM are described. Delay in the diagnosis of the first was associated with severe sequelae, while in the other two early diagnosis and institution of corticosteroid therapy which was facilitated by MRI, was associated with a better outcome. MRI should be carried out early once the diagosis of ADEM is entertained. 相似文献
202.
203.
目的艾滋病(AIDS),是严重危害人类健康的疾病,临床上症状多变,应提高对AIDS的认识。现将作者在西非工作期间收治的142例AIDS病例的临床表现作一介绍。方法病例均为当地黑人居民,男性89例,女性53例,年龄14~45岁,平均年龄27.65岁。用酶联免疫吸附法和快速法检测患者血清中HIV—1和 HIV—2抗体。结果 HIV—1型25例(35.00%);HIV-2型74例(52.11%);混合型32例(22.53%)。临床表现为脑膜脑炎或脑炎7例(4.93%);肺型27例(19.01%);胃肠道感染84例(59.15%):包括急性48例(33.80%),慢性24例(16.90%),急腹症12例(8.45%);皮肤粘膜损害18例(12.68%):卡波齐肉瘤6例(4.23%),带状疱疹2例(1.41%),皮炎10例(7.04%),病死率19.72%(28/142)。其传播途径以性传播为主,高达78.87%(112/142),其次是密切生活接触,未发现吸毒或输血者。结论艾滋病病死率高,病情复杂,且目前尚无特效药物,必须引起医护人员高度重视。 相似文献
204.
B. A. Johnson Donald R. Jasinski Gantt P. Galloway Henry Kranzler Robert Weinreib Raymond F. Anton Barbara J. Mason Michael J. Bohn Helen M. Pettinati Richard Rawson Christopher Clyde 《Psychopharmacology》1996,128(2):206-215
Four hundred and twenty-three alcohol dependent subjects were enrolled into a 12-week randomized, double-blind, placebo-controlled
study to determine the safety and efficacy of the 5-HT2 receptor antagonist, ritanserin (2.5 mg/day or 5 mg/day), in reducing alcohol intake and craving. All subjects received 1
week of single-blind placebo prior to randomization into the 11-week double-blind phase. Additionally, all subjects received
weekly individual sessions of manual-guided cognitive-behavioral therapy. Comparing the single-blind period with endpoint,
there was approximately a 23% reduction in drinks/day; 34% fall in the total number of drinking days/week; 22% decrease in
drinks/drinking day; and a 37% diminution in alcohol craving for all treatment groups. All treatment groups experienced a
beneficial clinical outcome as assessed by the Clinical Global Impression Scale. There was, however, no significant difference
between treatment groups on any of these measures of alcohol drinking, craving, or clinical outcome. Subjects were of relatively
high social functioning at baseline, and this did not change significantly during treatment. Treatment groups did not differ
significantly on either medication compliance or reported adverse events. Ritanserin treatment was associated with a dose-related
prolongation of subjects’ QTc interval recording on the electrocardiogram. These results suggest that alcohol dependent subjects
can show marked clinical improvement within a structured alcohol treatment program. These findings do not support an important
role for ritanserin in the treatment of alcohol dependence.
Received: 30 April 1996/Final version: 3 July 1996 相似文献
205.
Role of intracortical mechanisms in the late part of the silent period to transcranial stimulation of the human motor cortex 总被引:3,自引:0,他引:3
J.P. Brasil-Neto A. Cammarota J. Valls-Solé A. Pascual-Leone M. Hallett L. G. Cohen 《Acta neurologica Scandinavica》1995,92(5):383-386
Transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES) of the human motor cortex produce a silent period (SP) following motor evoked potentials (MEPs). The early part of the SP can be explained by decreased alpha motor neuron excitability, whereas the late part is presumably due to suprasegmental mechanisms. In order to determine the level of the suprasegmental contribution to the generation of SPs, we recorded excitatory and inhibitory responses to TMS, TES, and percutaneous electrical brainstem stimulation (PBS) in the voluntarily activated first dorsal interosseous muscle of the hand. Stimulus intensities were set so that PBS and TES induced MEPs with areas equal to or larger than those of MEPs obtained with TMS. This procedure revealed that SPs were 49% and 83% shorter with TES and PBS, respectively, than with TMS. As TMS is more effective than TES or PBS in activating cortical interneurons, these findings support the idea that a significant component of the SP arises from intracortical mechanisms. 相似文献
206.
非脱垂子宫经腹、阴式全切除术临床比较 总被引:1,自引:0,他引:1
目的 探讨非脱垂子宫经阴道与经腹全切术的临床比较。方法 2000年5月~2001年1月对阴式子宫全切术 (TVH)28例及腹式子宫全切术 (TAH)35例分为两组进行手术 ,对临床指标进行观察比较。结果 28例TVH手术均成功。平均重量255g(120~510g)。与TAH手术比较 ,其术后病率、肛门排气时间及术后住院天数有显著性差异 ( p<0.001及 p<0.05) ,但其手术时间及术中出血量无显著性差异 ( p>0.05)。结论 随着微创手术的开展 ,利用阴道天然孔道 ,经阴道切除较大的子宫是有效和安全的 ,手术的成功与术者经验、技术及子宫活动度有关 ,有合适器械也是手术成功的因素。 相似文献
207.
报道新化合物A-失碳-17β-羟基-17α-乙炔基-Δ3(5),9(10)-雌甾二烯-2-酮2的合成。文中探讨了用炔钾粗品对A-失碳-Δ3(5),9(10)-雌甾二烯-2,17-二酮1和A-失碳-6β,19-环氧-Δ3-雄甾-2,17-二酮3的选择性炔化,分别得标题化合物2(44%)及A-失碳-17β-羟基-17α-乙炔基-6β,19-环氧-Δ3雄甾-2-酮4(65%),4经还原性破开环氧、去羟甲基和去醋酰氧基合成了标题化合物2。四步总收率为34%。 相似文献
208.
目的:研究水杨醛-N′-(2-呋喃硫羰基)腙铜配合物(CSFC)在兔体内的药物动力学。方法:10只家兔静脉注射CSFC5mg·kg-1,用反相HPLC法测定血清药物浓度。结果:CSFC的血药浓度-时间曲线符合二室开放模型,主要药动学参数为:T12α=3.4±1.7min,T12β=65.5±14.6min,K12=0.1183±0.0669min-1,K21=0.0228±0.0065min-1,K10=0.1202±0.0407min-1,V0=0.305±0.184L·kg-1,CL=1.896±0.470L·kg-1·h-1,AUC=170.1±57.0mg·min-1·L-1。结论:CSFC在兔体内分布迅速而广泛,消除也较快。家兔静注5mg·kg-1,可维持抗结核杆菌有效血浓度6h。 相似文献
209.
B. A. Stoll 《Annals of oncology》1997,8(3):223-225
Background: The study reviews the anticancer properties of naturalisoflavones which occur in especially high concentration in soybeans. Itconsiders the suitability of soybean products for clinical trials aiming toreduce the progression of breast cancer.Methods: Evidence is reviewed that plant isoflavones such asgenistein show cytostatic activity against human mammary cancer cell linesin vitro and can also suppress carcinogen-induced mammary cancer inyoung and mature rats.Results: Plant isoflavones are converted in the bowel to compoundswith potential antioestrogenic and antioxidative properties. These compoundsshow cytostatic activity for both oestrogen receptor-positive and negativehuman mammary cancer cell lines, and also inhibit growth and progress of therat mammary cancer model. The high content of soybean products in the diet ofAsian women has been postulated as one reason for their relatively low breastcancer incidence.Conclusion: Preclinical studies suggest that soybean products begiven priority for clinical trials in breast cancer protection. A pilot studycould test soy protein supplements as long-term adjuvant dietary treatmentafter primary surgery for early breast cancer, looking for a decrease in therisk of recurrence or of second primary tumours. 相似文献
210.
功能性消化不良与幽门螺杆菌关系探讨 总被引:6,自引:0,他引:6
功能性消化不良是一种人群中发病率很高的消化系统症状群,其发病机理未完全阐明,本文通过对2742例各类型功能性消化不良患者的胃粘膜的幽门螺杆菌感染情况作分析,发现动力障碍型HP阳性率65.3%,溃疡型HP阳性率74%,胃食管反流型HP阳性率24%,特发型HP阳性率21.4%,前两型与后两型的阳性率差异有显著性(P〈0.05),而前两型之间阳性率差异无显著性(P〉0.05),说明HP与动力障碍型和溃疡 相似文献